181

Pexidartinib hydrochloride

181 Publications Verification

Cat. No.: HY-16749A

CAS No.: 2040295-03-0

Synonyms: PLX-3397 hydrochloride

Target:

c-Fms c-Kit Apoptosis

Research Areas:

Cancer

Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .

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181

Pexidartinib

181 Publications Verification

Cat. No.: HY-16749

CAS No.: 1029044-16-3

Synonyms: PLX-3397

Target:

c-Fms c-Kit Apoptosis

Research Areas:

Cancer

Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity. Pexidartinib has limited permeability to the blood-brain barrier, primarily through ABCB1 .

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13

GW2580

13 Cited Publications

Cat. No.: HY-10917

CAS No.: 870483-87-7

Purity: 99.90%

Target:

c-Fms

Research Areas:

Inflammation/Immunology Cancer

GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling .

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10

Dextran sulfate sodium salt (MW 35000-45000)

10 Cited Publications

Cat. No.: HY-116282C

CAS No.: 9011-18-1

Synonyms: DSS (MW 35000-45000); DXS (MW 35000-45000)

Target:

Apoptosis

Research Areas:

Infection Inflammation/Immunology Cancer

Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a polymer of dehydrated glucose with a molecular weight of approximately 35000-45000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a potent inducer of colitis. Dextran sulfate sodium salt (DSS) (MW 35000-45000) can be used to induce model acute colitis, chronic colitis, and colitis-related colon cancer. Dextran sulfate sodium salt (DSS) (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium .

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10

LDC1267

10 Cited Publications

Cat. No.: HY-12494

CAS No.: 1361030-48-9

Purity: 99.64%

Target:

TAM Receptor FLT3

Research Areas:

Neurological Disease Cancer

LDC1267 is a AXL/TAM/FLT3 inhibitor with IC₅₀ values of 42 nM, 130 nM, and 63 nM against AXL, MERTK, and TYRO3, respectively. LDC1267 blocks GAS6-induced AXL phosphorylation and the downstream AKT/ERK1/2 signaling pathway. LDC1267 inhibits cancer cell proliferation, colony formation, and glioblastoma cell invasion, without causing obvious impairment of cytotoxic autophagic flux. LDC1267 exerts a synergistic effect when used in combination with Imatinib (HY-15463) in chronic myeloid leukemia models. LDC1267 can be widely applied in studies related to glioblastoma and chronic myeloid leukemia .

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5

SC66

5 Cited Publications

Cat. No.: HY-19832

CAS No.: 871361-88-5

Target:

MOFs Akt Apoptosis

Research Areas:

Cancer

SC66 is an Akt inhibitor, reduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells.

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5

Bimiralisib

5 Cited Publications

Cat. No.: HY-12868

CAS No.: 1225037-39-7

Purity: 98.62%

Synonyms: PQR309

Target:

PI3K mTOR Apoptosis

Research Areas:

Cancer

Bimiralisib (PQR309) is an orally active, blood-brain barrier-penetrant PI3K/mTOR inhibitor with in vitro antiproliferative activity and in vivo antitumor activity. Bimiralisib induces G1 cell cycle arrest, apoptosis and cell death in cancer cells, while inhibiting cancer cell proliferation, migration, invasion, colony formation and spheroid generation. Bimiralisib upregulates the expression of E2F4. The combination of Bimiralisib with venetoclax enhances therapeutic efficacy in acute myeloid leukemia models. Bimiralisib can be used in cancer-related research .

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3

Phenylacetylglutamine

3 Cited Publications

Cat. No.: HY-W050026

CAS No.: 28047-15-6

Synonyms: NSC 203800; Phenylacetyl-L-glutamine

Category:

Human Gut Microbiota Metabolites Microorganisms Other disease Other Diseases Disease markers Amino acids Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation.

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3

Edicotinib

3 Cited Publications

Cat. No.: HY-109086

CAS No.: 1142363-52-7

Purity: 98.80%

Synonyms: JNJ-40346527; JNJ-527

Target:

c-Fms

Research Areas:

Neurological Disease Inflammation/Immunology Cancer

Edicotinib (JNJ-40346527) is a potent, selective, brain penetrant and orally active colony-stimulating factor-1 receptor (CSF-1R) inhibitor with an IC₅₀ of 3.2 nM. Edicotinib exhibits less inhibitory effects on KIT and FLT3 with IC₅₀ values of 20 nM and 190 nM, respectively . Edicotinib limits microglial expansion and attenuates microglial proliferation and neurodegeneration in mice. Edicotinib has the potential for Alzheimer’s disease and rheumatoid arthritis research .

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3

Estrone sulfate potassium

3 Cited Publications

Cat. No.: HY-113293A

CAS No.: 1240-04-6

Purity: 99.45%

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Endogenous Metabolite Estrogen Receptor/ERR

Estrone sulfate potassium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate potassium is also a substrate of the OATP1B3 transporter. Estrone sulfate potassium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate potassium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate potassium is applicable to breast cancer-related research .

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3

Estrone sulfate sodium

3 Cited Publications

Cat. No.: HY-113293B

CAS No.: 438-67-5

Purity: 99.84%

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Endogenous Metabolite Estrogen Receptor/ERR

Estrone sulfate sodium is an inactive endogenous estrogen that can be converted into Estrone (HY-B0234) and Estradiol (HY-B0141). Estrone sulfate sodium is also a substrate of the OATP1B3 transporter. Estrone sulfate sodium can be converted into Estrone and Estradiol in normal mammary parenchymal cells. Estrone sulfate sodium stimulates the growth of nitrosomethylurea-induced mammary tumors in ovariectomized rats and the colony formation of dispersed nitrosomethylurea mammary cells, with conversion into Estrone and Estradiol occurring both in vivo and in vitro during this process. Estrone sulfate sodium is applicable to breast cancer-related research .

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3

AU-24118

3 Cited Publications

Cat. No.: HY-163410

CAS No.: 3084244-26-5

Target:

PROTACs SWI/SNF Complex Apoptosis

Research Areas:

Cancer

AU-24118 is an orally active PROTAC degrader that recruits cereblon to target the degradation of SMARCA2, SMARCA4 and PBRM1. AU-24118 impairs the chromatin accessibility of oncogenic transcription factors, inhibits colony formation, dislodges chromatin-bound transcription factors, attenuates downstream signal transduction, induces apoptosis, and exerts antiproliferative and cytotoxic effects. AU-24118 can be used in research related to castration-resistant prostate cancer, colorectal cancer, small cell lung cancer and multiple myeloma (including the t (4;14) subtype) .

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