Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
compound L-2
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "compound L-2" in MCE Product Catalog:
Cat. No.: HY-16638
CAS No.: 76849-19-9
Synonyms: PDDF
Target:
Research Areas:
CB 3717 is a potent inhibitor of human thymidylate synthetase, competitively binding with 5,10-methylenetetrahydrofolate (Ki = 4.9 X 10(-9) M). It also competitively inhibits human dihydrofolate reductase with dihydrofolate (Ki = 2.3 X 10(-8) M). In WI-L2 human lymphoblastoid cells, CB 3717 treatment led to a significant decrease in cellular dTTP levels and a notable increase in dUMP levels, indicating a disruption in nucleotide metabolism. The growth-inhibitory effect of CB 3717 was reversed by thymidine supplementation, demonstrating that thymidylate synthetase became rate-limiting in the presence of this compound. Delayed thymidine supplementation beyond 8 hours resulted in severe cytotoxicity, underscoring the critical timing of nucleotide rescue strategies in CB 3717-treated cells .
Cat. No.: HY-159932
CAS No.: 3107600-77-8
SARS-CoV-2 Mpro-IN-30 (compound L2) is a SARS-CoV-2 Mpro with the IC50 of 9.1 nM .
Cat. No.: HY-179489
CAS No.: 1589567-51-0
Target:
Research Areas:
TRPC3 agonist-1 (compound 4n) is a selective and competitive TRPC3 channel agonist. TRPC3 agonist-1 binds at L2 site of hTRPC3 .
Cat. No.: HY-176531
CAS No.: 3049804-05-6
Antiviral agent 69 (Compound L2) is a capsid protein residue THR155-targeting inhibitor of phytoviral intercellular traffic. Antiviral agent 69 has an excellent antiviral activity against Potato virus Y (PVY) with an EC50 of 128.10 μg/mL for inactivation effect. Antiviral agent 69 effectively decreases viral accumulation in host plant Nicotiana benthamiana, promising for novel pesticide research and development .
Cat. No.: HY-L266
101 compounds
PD-1/PD-L1 signaling is a central negative regulatory axis that maintains immune homeostasis. It involves the specific binding of PD-1 to its ligands PD-L1/PD-L2 and the subsequent transduction of inhibitory signals, which suppress T cell activation and proliferation, drive T cell exhaustion, and contribute to tumor immune evasion. Dysregulation of this pathway is closely linked to major diseases including cancer, chronic viral infections, autoimmune disorders, and transplant rejection. Immune checkpoint blockade targeting PD-1/PD-L1 has emerged as a leading frontier in cancer therapy and mechanistic research.
The MCE PD-1 Compound Library contains 101 structurally defined small molecules, covering modulators related to the PD-1/PD-L1 signaling pathway. It can be used for cancer immunotherapy research, studies of immune resistance mechanisms, and candidate compound screening, providing chemical tools for immune checkpoint mechanism research, drug discovery, and high-throughput screening.
Cat. No.: HY-180765
Target:
Research Areas:
Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene (compound L2) is a lipophilic colchicinoid formulation targeting hepatic stellate cells (HSC). Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene increases the levels of MMP2, MMP8 and MMP9, demonstrating the protective effect in tissue remodeling. Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene exhibits anti-fibrotic activity in CCL4-induced liver fibrosis (LF) mouse model. Colchicine-O-CO-Enyl(Me)-Enyl-Enyl(Me)-Enyl-1,3,3-trimethylcyclohex-1-ene can be used for LF research .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
