9135 Results for "

conjugated flavone framework

" in MedChemExpress (MCE) Product Catalog:

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114

Tauroursodeoxycholate dihydrate

114 Publications Verification

Cat. No.: HY-19696B

CAS No.: 117609-50-4

Synonyms: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt

Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .

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101

VcMMAE

101 Cited Publications

Cat. No.: HY-15575

CAS No.: 646502-53-6

Purity: 99.94%

Synonyms: MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin

Target:

Drug-Linker Conjugates for ADC Microtubule/Tubulin

Research Areas:

Cancer

VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).

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Monomethyl auristatin E

63 Cited Publications

Cat. No.: HY-15162

CAS No.: 474645-27-7

Purity: 99.97%

Synonyms: MMAE; SGD-1010

Target:

Microtubule/Tubulin ADC Payloads Apoptosis

Research Areas:

Cancer

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

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Deruxtecan

35 Cited Publications

Cat. No.: HY-13631E

CAS No.: 1599440-13-7

Purity: 99.94%

Synonyms: MC-GGFG-DXD

Target:

Drug-Linker Conjugates for ADC

Research Areas:

Cancer

Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813) .

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Mertansine

30 Cited Publications

Cat. No.: HY-19792

CAS No.: 139504-50-0

Synonyms: DM1; Maytansinoid DM1

Target:

Microtubule/Tubulin ADC Payloads

Research Areas:

Cancer

Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC) .

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