2

2 Cited Publications

CAS No.: 620113-73-7

Target:

Research Areas:

Cardiovascular Disease Neurological Disease

CCG-63808 is a selective, reversible RGS4 inhibitor with an IC₅₀ of 10 μM for the Gα_o-RGS4 interaction . CCG-63808 enhances the contractile response of lymphatic smooth muscle and potentiates agonist-mediated thoracic duct contraction. CCG-63808 can be used in research related to neuropathic pain and hypertension .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Cyclic somatostatin

Cat. No.: HY-P0084

CAS No.: 38916-34-6

Synonyms: SRIF-14; Somatostatin-14

Target:

Endogenous Metabolite

Research Areas:

Cardiovascular Disease Neurological Disease

Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC₅₀ value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Lipopolysaccharides, from E. coli O127:B8

Cat. No.: HY-D1056A2

Synonyms: LPS, from Escherichia coli (O127:B8)

Lipopolysaccharides, from E. coli O127:B8 (LPS, from Escherichia coli (O127:B8)) are endotoxins and TLR4 activators extracted from Escherichia coli (E. coli O127:B8) and are classified as S (smooth) type LPS. Lipopolysaccharides, from E. coli O127:B8 possess the typical three-part structure: O-antigen, R3-type core oligosaccharide, and lipid A. Lipopolysaccharides, from E. coli O127:B8 activate TLR-4 in immune cells, can induce inflammatory responses and ileal contractility, and can be used to construct intestinal inflammation models .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3-Picolylamine

Cat. No.: HY-Y0047

CAS No.: 3731-52-0

Synonyms: Picolamine; 3-Pyridinemethanamine; Pyridin-3-ylmethanamine

Target:

Biochemical Assay Reagents

Research Areas:

Inflammation/Immunology

3-Picolylamine is a primary amine compound containing a pyridine ring structure. 3-Picolylamine inhibits histaminase (diamine oxidase) activity in pig kidneys. 3-Picolylamine significantly enhances the contractile response of isolated guinea pig ileum to Histamine (HY-B1204). 3-Picolylamine can be used to study histamine-related physiological mechanisms or allergic diseases (such as histamine-mediated inflammatory responses) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Captopril disulfide

Cat. No.: HY-123068

CAS No.: 64806-05-9

Purity: 99.29%

Synonyms: SQ 14551

Target:

Drug Derivative

Research Areas:

Cardiovascular Disease

Captopril disulfide (SQ 14551) is an orally active disulfide dimer prodrug. Captopril disulfide is metabolized to Captopril and acts as a Bradykinin potentiator. Captopril disulfide enhances the vasodilatory effect of Bradykinin in anesthetized rats and the contractile response of isolated guinea pig ileum to Bradykinin. Captopril disulfide exhibits antihypertensive activity in spontaneously hypertensive rats. Captopril disulfide can be used in hypertension-related research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

A-61603

Cat. No.: HY-101366

CAS No.: 107756-30-9

Purity: ≥99.0%

Target:

Adrenergic Receptor

Research Areas:

Endocrinology

A-61603 is a selective α₁A/α₁a-adrenergic receptor agonist with K_i of 8.89 nM for rat submaxillary gland α1A, K_i of 30.5 nM for cloned bovine α1a. A-61603 potentiates Ca ²⁺ transients with EC₅₀ of 6.9 nM. A-61603 stimulates phosphoinositide hydrolysis, induces contractile responses in vas deferens, prostate strips, and spleen strips, and exhibits low activity in aortic rings. A-61603 can be used for research on adrenergic function .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Sar-[D-Phe8]-des-Arg9-Bradykinin

Cat. No.: HY-103291

CAS No.: 126959-88-4

Purity: 99.96%

Target:

Bradykinin Receptor

Research Areas:

Inflammation/Immunology Endocrinology

Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings .

Compare

loading...