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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
coupling partner
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "coupling partner" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-D2171A
1
1 Cited Publications
Cat. No.: HY-D2171
Cat. No.: HY-D1314
CAS No.: 1386385-76-7
Synonyms: 6-FAM azide
Cat. No.: HY-170704
CAS No.: 1480940-53-1
Target:
Research Areas:
DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis .
Cat. No.: HY-32748
CAS No.: 41404-58-4
Research Areas:
2-Bromo-5-fluoropyridine acts as a bromofluoropyridine starting material and an azaaryl halide coupling partner. 2-Bromo-5-fluoropyridine participates in an oxygen-promoted, ligand-free Pd (OAc)2-catalyzed Suzuki reaction, reacting with arylboronic acids to produce 5-fluoro-2-aryl-substituted pyridine derivatives. 2-Bromo-5-fluoropyridine can be used to synthesize 5-fluoro-2-(4-(methylsulfonyl) phenyl) pyridine, an intermediate of the GPR119 agonist GSK1292263A .
Cat. No.: HY-32927
CAS No.: 150255-96-2
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Research Areas:
3-Cyanophenylboronic acid is an arylboronic acid-based boronic acid reagent that serves as a coupling partner in Suzuki-Miyaura cross-coupling reactions. 3-Cyanophenylboronic acid participates in reactions to synthesize 4'-propoxybiphenyl-3-carbonitrile .
Cat. No.: HY-W001194
CAS No.: 5908-62-3
Synonyms: 1,1-Dioxoisothiazolidine
Research Areas:
1,3-Propanesultam (1,1-Dioxoisothiazolidine) is a cyclic sulfonamide monomer. Polymerization of 1,3-Propanesultam under base catalysis produces high-molecular-weight polypropanesulfonamide, while polymerization under acid catalysis yields low-molecular-weight polypropanesulfonamide. 1,3-Propanesultam serves as a coupling partner in copper-catalyzed C-N cross-coupling reactions for the synthesis of 3-aminopyrazole phenylacetamide analogs. 1,3-Propanesultam is applicable to research related to organic synthesis .
Cat. No.: HY-W000873
CAS No.: 146631-00-7
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Research Areas:
4-Benzyloxyphenylboronic acid is an arylboronic acid reagent that generates Monobenzone (HY-30272), a compound that inhibits melanin production in the skin, via electrochemical deboronation hydroxylation. 4-Benzyloxyphenylboronic acid serves as a coupling partner in Pd (0)-catalyzed Suzuki-Miyaura cross-coupling reactions for the synthesis of bent-core liquid crystals and liquid crystalline amphiphiles. 4-Benzyloxyphenylboronic acid is used in the study of hyperpigmentation .
Cat. No.: HY-L257
190 compounds
Linkers, as key structural units in PROTAC molecules that connect the two functional ends, not only determine the overall molecular conformation and spatial compatibility but also directly influence the stability of the ternary complex, as well as cellular permeability and degradation efficiency. In recent years, with the widespread application of click chemistry in medicinal chemistry, the incorporation of bioorthogonal reactive groups such as azides (-N3) into PROTAC linker design has become an emerging research focus, providing an important tool for modular assembly and rapid structural optimization.
The MCE Azide PROTAC Linker Library contains 190 linkers specifically designed for targeted protein degradation molecule design and optimization. These linkers serve as efficient “click handles,” enabling rapid and highly selective covalent coupling with alkyne reaction partners, thereby facilitating modular assembly and structural diversification of PROTAC molecules. In drug development, this design not only improves the efficiency of molecular construction but also significantly accelerates the screening and optimization of lead compounds. Meanwhile, by tuning linker properties such as length, flexibility, and polarity, the ability to form ternary complexes and degradation activity can be optimized.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
