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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1 Result for "
coxibs
" in MedChemExpress (MCE) Product Catalog:
Products (1)
1 Results for "coxibs" in MCE Product Catalog:
Cat. No.: HY-189571
Target:
Drug Intermediate Interleukin Related Bcl-2 Family Survivin Caspase Reactive Oxygen Species (ROS)
Research Areas:
Cou-Coxib is a ROS-responsive fluorescent Celecoxib (HY-14398) prodrug that is activated by ROS triggering and self-immolation to release Celecoxib and the fluorophore Cou-OH. Celecoxib released from Cou-Coxib elevates intracellular ROS levels, induces S-phase arrest in MDA-MB-231 triple-negative breast cancer cells, and downregulates the expression of apoptosis-related proteins Bcl2, Survivin, and procaspase-3. In the H9C2 cardiomyoblast model, Cou-Coxib attenuates the cardiotoxicity caused by Celecoxib, maintains mitochondrial membrane potential, upregulates IL-10, and exhibits biocompatibility in developing zebrafish embryos. Cou-Coxib can be used for research on triple-negative breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
