436 Results for "

craniofacial abnormalities

" in MedChemExpress (MCE) Product Catalog:

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305

Verteporfin

305 Publications Verification

Cat. No.: HY-B0146

CAS No.: 129497-78-5

Synonyms: CL 318952

Target:

YAP Apoptosis Autophagy Photosensitizer

Research Areas:

Cancer

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis . Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation .

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Alisertib

82 Cited Publications

Cat. No.: HY-10971

CAS No.: 1028486-01-2

Purity: 99.36%

Synonyms: MLN 8237

Target:

Aurora Kinase Autophagy Apoptosis

Research Areas:

Cancer

Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC₅₀=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity .

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Nicotinamide riboside chloride

31 Cited Publications

Cat. No.: HY-123033A

CAS No.: 23111-00-4

Purity: 99.90%

Category:

Alkaloids Neurological Disease Animals Anti-aging Pyridine Alkaloids Metabolic Disease Disease Research Fields

Target:

Sirtuin Endogenous Metabolite

Nicotinamide riboside Chloride, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

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Nicotinamide riboside tartrate

31 Cited Publications

Cat. No.: HY-123033B

CAS No.: 2415657-86-0

Category:

Natural Products Neurological Disease Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Sirtuin Endogenous Metabolite

Nicotinamide riboside tartrate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

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Nicotinamide riboside malate

31 Cited Publications

Cat. No.: HY-123033C

CAS No.: 2415659-01-5

Purity: 98.04%

Category:

Natural Products Neurological Disease Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Sirtuin Endogenous Metabolite

Nicotinamide riboside malate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

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