6

6 Publications Verification

Synonyms: NSC13123

Category:

Infection Natural Products Disease markers Metabolic Disease Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite GABA Receptor iGluR

Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure .

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5

Creatinine-d3

5 Cited Publications

Cat. No.: HY-B0504S

CAS No.: 143827-20-7

Synonyms: NSC13123-d₃

Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure .

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4

SDMA

4 Cited Publications

Cat. No.: HY-101410

CAS No.: 30344-00-4

Purity: ≥98.0%

Synonyms: Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine

Category:

Human Gut Microbiota Metabolites Other disease Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NO Synthase NF-κB

SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA, a novel kidney biomarker, permits earlier diagnosis of kidney disease than traditional creatinine testing.

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2

Ketone monoester

2 Cited Publications

Cat. No.: HY-15344

CAS No.: 1208313-97-6

Purity: ≥95.0%

Target:

Biochemical Assay Reagents

Research Areas:

Neurological Disease Metabolic Disease

Ketone monoester is an orally available ketone monoester that serves as a source of nutritional ketones. Ketone monoester increases plasma beta-hydroxybutyrate, acetoacetate, blood glucose, blood sodium, and blood creatinine levels in mouse models. Ketone monoester has the potential to improve athletic performance and endurance in animals. Ketone monoester partially prevents myasthenia in septic mice. Ketone monoester may also be used to study Parkinson's disease or diabetes .

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2

Creatininase, Microorganism

2 Cited Publications

Cat. No.: HY-P2838

CAS No.: 9025-13-2

Synonyms: creatinine amidohydrolase; CAH

Target:

Biochemical Assay Reagents

Research Areas:

Metabolic Disease

Creatininase, Microorganism (Creatinine amidohydrolase; CAH), namely creatinine amidohydrolase, from Pseudomonas putida, is a homohexameric enzyme commonly used in biochemical research. Creatininase acts on carbon-nitrogen bonds other than peptide bonds, and can catalyze the hydrolysis of creatinine to creatine, which can then be metabolized by creatinase to urea and sarcosine .

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2

Trichlormethiazide

2 Cited Publications

Cat. No.: HY-B0235

CAS No.: 133-67-5

Target:

Carbonic Anhydrase

Research Areas:

Metabolic Disease

Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .

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2

Dioctyl phthalate

2 Cited Publications

Cat. No.: HY-W013755

CAS No.: 117-84-0

Synonyms: DNOP; Di-n-octyl phthalate; Phthalic acid dioctyl ester

Target:

Biochemical Assay Reagents Aminotransferases (Transaminases) Phosphatase Bacterial

Research Areas:

Inflammation/Immunology

Dioctyl phthalate (DNOP) is a plasticizer. Dioctyl phthalate increases the activities of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in the liver, as well as the levels of creatinine and urea in the kidney. Exposure to Dioctyl phthalate disrupts the homeostasis of the intestinal microbial community, increases the abundance of pathogenic bacteria, and reduces the abundance of beneficial bacteria such as Lactobacillus. Dioctyl phthalate induces significant and dose-dependent inflammatory responses in the liver, spleen and kidney of mice .

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1

Sibeprenlimab

1 Cited Publications

Cat. No.: HY-P99901

CAS No.: 2382896-07-1

Synonyms: VIS649

Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN) .

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1

Poricoic acid A

1 Cited Publications

Cat. No.: HY-N2995

CAS No.: 137551-38-3

Synonyms: Poricoic acid A(F)

Category:

Triterpenes Terpenoids Polyporaceae Extract 500 - Internal Server Error | MedChemExpress

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