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245 Results for "

cytotoxic effect

" in MedChemExpress (MCE) Product Catalog:

Products (245)

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Valinomycin

10 Cited Publications

Cat. No.: HY-N6693

CAS No.: 2001-95-8

Synonyms: NSC 122023

Category:

Infection Microorganisms Antibiotics Disease Research Anticancer Disease Research Fields Other Antibiotics

Target:

Apoptosis Antibiotic Autophagy Fungal

Valinomycin is a potassium-specific ionophore, the valinomycin-K ⁺ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K ⁺ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .

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LDC1267

10 Cited Publications

Cat. No.: HY-12494

CAS No.: 1361030-48-9

Purity: 99.64%

Target:

TAM Receptor FLT3

Research Areas:

Neurological Disease Cancer

LDC1267 is a AXL/TAM/FLT3 inhibitor with IC₅₀ values of 42 nM, 130 nM, and 63 nM against AXL, MERTK, and TYRO3, respectively. LDC1267 blocks GAS6-induced AXL phosphorylation and the downstream AKT/ERK1/2 signaling pathway. LDC1267 inhibits cancer cell proliferation, colony formation, and glioblastoma cell invasion, without causing obvious impairment of cytotoxic autophagic flux. LDC1267 exerts a synergistic effect when used in combination with Imatinib (HY-15463) in chronic myeloid leukemia models. LDC1267 can be widely applied in studies related to glioblastoma and chronic myeloid leukemia .

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β-Amyloid (1-42), (rat/mouse)

9 Cited Publications

Cat. No.: HY-P1388

CAS No.: 166090-74-0

Synonyms: Amyloid β-peptide (1-42) (rat/mouse)

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-42), (rat/mouse) is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

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β-Amyloid (1-42), (rat/mouse) TFA

9 Cited Publications

Cat. No.: HY-P1388A

Synonyms: Amyloid β-peptide (1-42) (rat/mouse) TFA

Target:

Amyloid-β

Research Areas:

Neurological Disease

β-Amyloid (1-42), (rat/mouse) TFA is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

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ML346

8 Cited Publications

Cat. No.: HY-18669

CAS No.: 100872-83-1

Target:

HSP

Research Areas:

Cancer

ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC₅₀ of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27 .

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