4

4 Cited Publications

Cat. No.: HY-19759

CAS No.: 1001908-89-9

Target:

Research Areas:

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC_1.5 value of 0.36 μM . SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels .

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4

TAK-683 acetate

4 Cited Publications

Cat. No.: HY-P2161B

Target:

Kisspeptin Receptor

Research Areas:

Cancer

TAK-683 acetate is a potent full KISS1 receptor (KISS1R) agonist (IC₅₀=170 pM) with improved metabolic stability. TAK-683 acetate is a nonapeptide metastin analog, exhibits agonistic activities to KISS1R with EC₅₀ values of 0.96 nM and 1.6 nM for human and rat, respectively . TAK-683 acetate depletes GnRH in the hypothalamus and reduces plasma FSH, LH, and testosterone levels in vivo, it has the potential for the study of hormone-dependent prostate cancer .

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3

MDL-800

3 Cited Publications

Cat. No.: HY-119376

CAS No.: 2275619-53-7

Purity: 99.11%

Target:

Sirtuin

Research Areas:

Cancer

MDL-800 is an allosteric and selective SIRT6 activator. MDL-800 increases SIRT6 deacetylation activity with an EC₅₀ of 10.3 µM .

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1

BPK-25

1 Cited Publications

Cat. No.: HY-141550

CAS No.: 2305052-86-0

Purity: 99.92%

Target:

NF-κB

Research Areas:

Inflammation/Immunology

BPK-25, an active acrylamide, promotes degradation of nucleosome remodeling and deacetylation (NuRD) complex proteins by a post-translational mechanism involving covalent protein engagement. BPK-25 inhibits TMEM173 activation by the cyclic dinucleotide ligand cGAMP .

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1

3,4-Dimethoxychalcone

1 Cited Publications

Cat. No.: HY-W083373A

CAS No.: 5416-71-7

Target:

Bacterial Autophagy

Research Areas:

Cancer

3,4-Dimethoxychalcone is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research .

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1

4-Hydroxyestrone

1 Cited Publications

Cat. No.: HY-W009300

CAS No.: 3131-23-5

Synonyms: 4-OHE1

Category:

Neurological Disease Animals Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite Estrogen Receptor/ERR Sirtuin MDM-2/p53 PDI Ferroptosis Reactive Oxygen Species (ROS)

4-Hydroxyestrone (4-OHE1) is a brain-penetrant estrogen metabolite. 4-Hydroxyestrone shows neuroprotective effects involving increased cytoplasmic localization of p53 resulting from SIRT1-mediated p53 deacetylation. 4-Hydroxyestrone relies on PDI to mediate its protective effect against chemically induced ferroptosis in estrogen receptor-negative cancer cells. 4-Hydroxyestrone inhibits lipid peroxidation and lipid-ROS accumulation. 4-Hydroxyestrone blocks preovulatory luteinizing hormone surges in Rattus norvegicus. 4-Hydroxyestrone can be used for the researches of neurodegeneration, breast cancer and endocrine disease .

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Trimethylammonium chloride

Cat. No.: HY-Y0504

CAS No.: 593-81-7

Synonyms: Hegzadesil; Trimethylamine hydrochloric acid; Trimethylamine monohydrochloride

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Cholinesterase (ChE) Endogenous Metabolite

Trimethylammonium chloride (Hegzadesil) is a non-competitive Acetylcholinesterase inhibitor. Trimethylammonium chloride reversibly blocks the deacetylation of acetylcholinesterase .

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Ac-RHKK(Ac)-AMC

Cat. No.: HY-P11212

CAS No.: 1193634-36-4

Target:

Fluorescent Dye

Research Areas:

Metabolic Disease Cancer

Ac-RHKK(Ac)-AMC (Compound S1) is a fluorescent substrate for SITR6, that is based on p53 sequence. Ac-RHKK(Ac)-AMC mimics H3K56 deacetylation site and significantly increases the deacetylation signal with low signal-to-background ratio. Ac-RHKK(Ac)-AMC can be used for ageing and cancers research .

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Trimethylammonium chloride-d9

Cat. No.: HY-Y0504S3

CAS No.: 18856-86-5

Trimethylammonium chloride-d₉ is the d₉-labeled Trimethylammonium chloride (HY-Y0504). Trimethylammonium chloride (Hegzadesil) is a non-competitive Acetylcholinesterase inhibitor. Trimethylammonium chloride reversibly blocks the deacetylation of acetylcholinesterase .

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