52

N-Ethylmaleimide

52 Publications Verification

Cat. No.: HY-D0843

CAS No.: 128-53-0

Synonyms: NEM

Target:

Cathepsin Deubiquitinase Apoptosis

Research Areas:

Infection Inflammation/Immunology

N-Ethylmaleimide (NEM) derives from maleic acid, it can alkylates free sulfhydryl. N-Ethylmaleimide is an irreversible cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria. N-Ethylmaleimide inhibits prolyl endopeptidase with an IC₅₀ value of 6.3 μM. N-Ethylmaleimide can be used to modify cysteine residues in proteins and peptides .

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16

HA Peptide

16 Cited Publications

Cat. No.: HY-P0239

CAS No.: 92000-76-5

Category:

Natural Products Microorganisms Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Influenza Virus

HA Peptide (HA tag) is a nine amino acids peptide derived from the human influenza hemagglutinin (HA). HA Peptide is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry.

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16

HA Peptide TFA

16 Cited Publications

Cat. No.: HY-P0239A

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Influenza Virus

HA Peptide (TFA) is a nine amino acids peptide derived from the human influenza hemagglutinin (HA). HA Peptide (TFA) is extensively used to isolate, purify, detect, and track the protein of interest in cell biology and biochemistry .

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14

DOPE

14 Cited Publications

Cat. No.: HY-112005

CAS No.: 4004-05-1

Purity: 98.80%

Synonyms: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

Target:

Liposome Endogenous Metabolite ACSL Family Amino acid Transporter Ferroptosis Glutathione Peroxidase

Research Areas:

Inflammation/Immunology Cancer

DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease .

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7

Tat-beclin 1

7 Cited Publications

Cat. No.: HY-P2260

CAS No.: 1423821-88-8

Target:

CHIKV Autophagy HIV

Research Areas:

Infection

Tat-beclin 1, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) .

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6

LL-37, human

6 Cited Publications

Cat. No.: HY-P1222

CAS No.: 154947-66-7

Target:

Bacterial

Research Areas:

Infection

LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing .

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6

LL-37, human acetate

6 Cited Publications

Cat. No.: HY-P1222B

Target:

Bacterial

Research Areas:

Infection Inflammation/Immunology

LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing .

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6

Epsilon-V1-2

6 Cited Publications

Cat. No.: HY-P0154

CAS No.: 182683-50-7

Synonyms: ε-V1-2; EAVSLKPT

Target:

PKC

Research Areas:

Inflammation/Immunology

Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC .

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6

LL-37, human TFA

6 Cited Publications

Cat. No.: HY-P1222A

Target:

Bacterial

Research Areas:

Infection

LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing .

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6

Gap19

6 Cited Publications

Cat. No.: HY-P1136

CAS No.: 1507930-57-5

Target:

Gap Junction Protein

Research Areas:

Cardiovascular Disease

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

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6

Gap19 TFA

6 Cited Publications

Cat. No.: HY-P1136A

Target:

Gap Junction Protein

Research Areas:

Cardiovascular Disease

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

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5

COG1410

5 Cited Publications

Cat. No.: HY-P2136

CAS No.: 878009-24-6

Target:

Apolipoprotein Apoptosis

Research Areas:

Neurological Disease Inflammation/Immunology

COG1410 is an apolipoprotein E-derived peptide and an apoptosis inhibitor. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease .

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5

Cyclosporin H

5 Cited Publications

Cat. No.: HY-P1122

CAS No.: 83602-39-5

Target:

Formyl Peptide Receptor (FPR)

Research Areas:

Infection Inflammation/Immunology

Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.

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4

KRFK TFA

4 Cited Publications

Cat. No.: HY-P3970A

Target:

TGF-β Receptor

Research Areas:

Inflammation/Immunology

KRFK TFA, a peptide derived from TSP-1, can activate TGF-β. KRFK TFA promotes TGF-β-mediated signaling and its downstream role, independent of thrombospondin (TSP) receptors such as CD47 and CD36. KRFK TFA can be used for chronic ocular surface inflammatory disorders reseach .

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