6

Hydroxyprogesterone caproate

6 Publications Verification

Cat. No.: HY-B0742

CAS No.: 630-56-8

Synonyms: 17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate

Target:

Progesterone Receptor

Research Areas:

Endocrinology

Hydroxyprogesterone caproate (17α-Hydroxyprogesterone hexanoate; 17α-Hydroxyprogesterone caproate) is a progesterone receptor (progesterone receptor) ligand and steroid hormone transcription inhibitor. Hydroxyprogesterone caproate downregulates estrogen receptors in target tissues and activates their metabolic pathways, and exhibits equivalent affinity for progesterone receptor A and progesterone receptor B. Hydroxyprogesterone caproate shows no consistent teratogenicity or developmental toxicity in rat, mouse and monkey models, but induces resorption or abortion in rhesus monkeys at human-equivalent doses. Hydroxyprogesterone caproate promotes the production of TNF-α in lipopolysaccharide-stimulated whole blood from non-pregnant women. Hydroxyprogesterone caproate can be used in scientific research related to preterm birth .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Monobutyl phthalate

5 Cited Publications

Cat. No.: HY-N7143

CAS No.: 131-70-4

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Drug Metabolite

Monobutyl phthalate is an orally active metabolite of Di-n-butyl phthalate (HY-Y0304) and an embryotoxic agent. Monobutyl phthalate regulates mesodermal lineage gene expression, inhibits uterine decidualization, reduces fetal testosterone levels without directly binding to the androgen receptor, and induces teratogenic effects during organogenesis. Monobutyl phthalate induces testicular oxidative stress and sperm abnormalities. Monobutyl phthalate can be used in studies of developmental toxicity and male reproductive toxicity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Propiconazole

2 Cited Publications

Cat. No.: HY-B0847

CAS No.: 60207-90-1

Target:

Environmental Pollutants Reactive Oxygen Species (ROS) Fungal

Research Areas:

Infection

Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

DL-Panthenol

2 Cited Publications

Cat. No.: HY-B1024

CAS No.: 16485-10-2

Synonyms: DL-Pantothenol; DL-Pantothenyl alcohol

DL-Panthenol (DL-Pantothenol) is a precursor of pantothenic acid. DL-Panthenol easily penetrates the skin and has effects of deep moisturizing, promoting wound healing and anti-inflammation. DL-Panthenol can also be used as a hair conditioner in cosmetics. DL-Panthenol has low acute toxicity, non-sensitizing property, and no significant genotoxicity or reproductive and developmental toxicity. DL-Panthenol can be applied to the research of cosmetics .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Perfluoro(2-methyl-3-oxahexanoic) acid

1 Cited Publications

Cat. No.: HY-W081067

CAS No.: 13252-13-6

Synonyms: HFPO-DA

Target:

PPAR

Research Areas:

Infection

Perfluoro (2-methyl-3-oxahexanoic) acid (HFPO-DA) is an orally active PPARα agonist with an EC₅₀ of 2.1 μM for human PPARα. Perfluoro (2-methyl-3-oxahexanoic) acid induces peroxisome proliferation and increases the levels of proinflammatory mediators. It impairs intestinal barrier function and disrupts cecal flora balance. Perfluoro (2-methyl-3-oxahexanoic) acid is applicable to research related to developmental toxicity, hepatotoxicity and intestinal toxicity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Perfluorobutanesulfonic acid

1 Cited Publications

Cat. No.: HY-21191

CAS No.: 375-73-5

Synonyms: PFBS

Target:

Biochemical Assay Reagents PPAR Reactive Oxygen Species (ROS)

Research Areas:

Metabolic Disease

Perfluorobutanesulfonic acid (PFBS) is a short-chain perfluoroalkyl substance and the main replacement for perfluorooctanesulfonic acid. Perfluorobutanesulfonic acid induces fat accumulation in human HepG2 hepatoma cells. Perfluorobutanesulfonic acid promotes lipid accumulation by activating PPARγ pathway and triggering oxidative stress, endoplasmic reticulum stress and calcium dyshomeostasis. Perfluorobutanesulfonic acid impairs reproduction and causes developmental disorders in offspring of Caenorhabditis elegans. Perfluorobutanesulfonic acid disrupts pancreatic organogenesis and lipid homeostasis in zebrafish embryos. Perfluorobutanesulfonic acid can be used in environmental toxicology, lipid metabolism and developmental toxicity studies .

Compare

loading...