2418 Results for "

disorder

" in MedChemExpress (MCE) Product Catalog:
Products (2418)

2418 Results for "disorder" in MCE Product Catalog:

161
Chlorpromazine
Chlorpromazine
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161 Publications Verification
Cat. No.: HY-12708
CAS No.: 50-53-3
Purity:  99.75%
Target:  

Dopamine Receptor Cytochrome P450 Autophagy 5-HT Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine also can inhibit clathrin-mediated endocytosis .
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161
Chlorpromazine hydrochloride
Chlorpromazine hydrochloride
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161 Publications Verification
Cat. No.: HY-B0407A
CAS No.: 69-09-0
Target:  

Dopamine Receptor Autophagy Cytochrome P450 5-HT Receptor

Research Areas:  

Cardiovascular Disease Neurological Disease Cancer

Chlorpromazine hydrochloride is an orally active, blood-brain barrier-transparent antipsychotic agent that effectively antagonises D2 dopamine receptors and 5-HT2A, which is widely used in schizophrenia and other psychiatric disorders. Chlorpromazine hydrochloride exerts anti-cancer activity through a variety of pathways, including anti-proliferation, induction of autophagy and cycle arrest (G2-M phase), inhibition of cytochrome c oxidase (CcO), inhibition of tumour growth and metastasis, and inhibition of tumour immune escape. Chlorpromazine hydrochloride also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM), which has potential for analgesic and cardiac arrhythmic studies. Chlorpromazine hydrochloride also can inhibit clathrin-mediated endocytosis .
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134
Elesclomol
Elesclomol
0 Images
134 Cited Publications
Cat. No.: HY-12040
CAS No.: 488832-69-5
Purity:  99.80%
Synonyms: STA-4783
Target:  

Reactive Oxygen Species (ROS) Apoptosis Cuproptosis

Research Areas:  

Cancer

Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .
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105
Tofacitinib
Tofacitinib
0 Images
105 Cited Publications
Cat. No.: HY-40354
CAS No.: 477600-75-2
Synonyms: Tasocitinib; CP-690550
Target:  

JAK STAT NF-κB

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology

Tofacitinib (Tasocitinib) is an orally active, blood-brain barrier permeable selective inhibitor of JAK1/JAK3. Tofacitinib blocks the JAK-STAT/NF-κB signaling pathway, inhibits cytokine signal transduction, phosphorylation of STAT1/STAT5, and suppresses innate and adaptive immune responses. Tofacitinib can be used in research related to major depressive disorder, rheumatoid arthritis, pulmonary diseases, systemic lupus erythematosus, and immune-mediated liver injury .
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105
Tofacitinib citrate
Tofacitinib citrate
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105 Cited Publications
Cat. No.: HY-40354A
CAS No.: 540737-29-9
Synonyms: Tasocitinib citrate; CP-690550 citrate
Target:  

JAK STAT NF-κB

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology

Tofacitinib citrate (Tasocitinib citrate) is an orally active, blood-brain barrier permeable selective inhibitor of JAK1/JAK3. Tofacitinib citrate blocks the JAK-STAT/NF-κB signaling pathway, inhibits cytokine signal transduction, phosphorylation of STAT1/STAT5, and suppresses innate and adaptive immune responses. Tofacitinib citrate can be used in research related to major depressive disorder, rheumatoid arthritis, pulmonary diseases, systemic lupus erythematosus, and immune-mediated liver injury .
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91
Capsaicin
Capsaicin
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91 Cited Publications
Cat. No.: HY-10448
CAS No.: 404-86-4
Purity:  99.79%
Synonyms: (E)-Capsaicin
Category:  

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