2077 Results for "

disruption

" in MedChemExpress (MCE) Product Catalog:

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935

Erastin

935 Publications Verification

Cat. No.: HY-15763

CAS No.: 571203-78-6

Purity: 99.62%

Target:

VDAC Ferroptosis Disulfidptosis

Research Areas:

Cancer

Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation .

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657

Adezmapimod hydrochloride

657 Cited Publications

Cat. No.: HY-10256A

CAS No.: 869185-85-3

Purity: 99.37%

Synonyms: SB 203580 hydrochloride; RWJ 64809 hydrochloride

Target:

Organoid p38 MAPK Autophagy Mitophagy

Research Areas:

Inflammation/Immunology Cancer

Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator .

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657

Adezmapimod

657 Cited Publications

Cat. No.: HY-10256

CAS No.: 152121-47-6

Purity: 99.92%

Synonyms: SB 203580; RWJ 64809

Target:

Organoid p38 MAPK Autophagy Mitophagy HSP

Research Areas:

Inflammation/Immunology Cancer

Adezmapimod (SB 203580) is a selective and ATP-competitive p38 MAPK inhibitor with IC₅₀s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod inhibits LCK, GSK3β and PKBα with IC₅₀s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod can inhibit p38 MAPK and lead to the inhibition of downstream HSP27 phosphorylation. Adezmapimod does not disrupt JNK activity and is an autophagy and mitophagy activator .

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305

Verteporfin

305 Cited Publications

Cat. No.: HY-B0146

CAS No.: 129497-78-5

Synonyms: CL 318952

Target:

YAP Apoptosis Autophagy Photosensitizer

Research Areas:

Cancer

Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis . Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation .

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286

Bortezomib

286 Cited Publications

Cat. No.: HY-10227

CAS No.: 179324-69-7

Purity: 99.91%

Synonyms: PS-341; LDP-341; NSC 681239

Target:

Proteasome NF-κB Apoptosis Autophagy TREM receptor Ligands for Target Protein for PROTAC

Research Areas:

Cancer

Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (K_i=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM) . Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs) .

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243

Pevonedistat hydrochloride

243 Cited Publications

Cat. No.: HY-10484

CAS No.: 1160295-21-5

Purity: 98.58%

Synonyms: MLN4924 hydrochloride

Target:

NEDD8-activating Enzyme Apoptosis

Research Areas:

Cancer

Pevonedistat (MLN4924) hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor, with an IC₅₀ of 4.7 nM. Pevonedistat hydrochloride induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat hydrochloride suppresses the growth of human tumour xenografts in mice .

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243

Pevonedistat

243 Cited Publications

Cat. No.: HY-70062

CAS No.: 905579-51-3

Synonyms: MLN4924

Target:

NEDD8-activating Enzyme Apoptosis

Research Areas:

Cancer

Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC₅₀ of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice .

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135

Nocodazole

135 Cited Publications

Cat. No.: HY-13520

CAS No.: 31430-18-9

Purity: 99.59%

Synonyms: Oncodazole; R17934

Target:

Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis

Research Areas:

Cancer

Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.

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114

Tauroursodeoxycholate dihydrate

114 Cited Publications

Cat. No.: HY-19696B

CAS No.: 117609-50-4

Synonyms: Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate

Category:

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt

Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .

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102

FITC-Dextran (MW 10000)

102 Cited Publications

Cat. No.: HY-128868

CAS No.: 60842-46-8

FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

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102

FITC-Dextran (MW 4000)

102 Cited Publications

Cat. No.: HY-128868A

CAS No.: 60842-46-8

FITC-Dextran (MW 4000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 4000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 4000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption .

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101

TAK-243

101 Cited Publications

Cat. No.: HY-100487

CAS No.: 1450833-55-2

Purity: 98.38%

Synonyms: MLN7243

Target:

E1/E2/E3 Enzyme NF-κB Apoptosis

Research Areas:

Cancer

TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC₅₀=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis .

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Panobinostat lactate

90 Cited Publications

Cat. No.: HY-10224A

CAS No.: 960055-56-5

Purity: 98.67%

Synonyms: LBH589 lactate; NVP-LBH589 lactate

Target:

HDAC HIV Autophagy Apoptosis

Research Areas:

Infection Cancer

Panobinostat lactate is a potent and orally active non-selective HDAC inhibitor. Panobinostat lactate has antineoplastic activities. Panobinostat lactate effectively disrupts HIV latency. Panobinostat lactate induces cell apoptosis and autophagy. Panobinostat lactate can be used for the study of refractory or relapsed multiple myeloma .

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