35 Results for "

diuresis.

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "diuresis." in MCE Product Catalog:

14
Conivaptan hydrochloride
Conivaptan hydrochloride
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14 Publications Verification
Cat. No.: HY-18347A
CAS No.: 168626-94-6
Synonyms: YM 087
Target:  

Vasopressin Receptor Cytochrome P450

Conivaptan hydrochloride (YM 087) is an orally active dual vasopressin V1a/V2 receptor antagonist with Ki values of 0.48 nM and 3.04 nM for vasopressin V1a receptor and V2 receptor, respectively. Conivaptan hydrochloride competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan hydrochloride inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan hydrochloride induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan hydrochloride is used for research on hyponatremia and congestive heart failure .
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9
Engeletin
Engeletin
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9 Cited Publications
Cat. No.: HY-N0436
CAS No.: 572-31-6
Category:  

Plants Liliaceae Extract Flavanonols Flavonoids Microorganisms Phenols Polyphenols 500 - Internal Server Error | MedChemExpress

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