9

Phentolamine

9 Publications Verification

Cat. No.: HY-12717

CAS No.: 50-60-2

Purity: 99.94%

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease Endocrinology

Phentolamine is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine reduces systemic vascular resistance and increases cardiac output. Phentolamine improves erectile dysfunction. Phentolamine can be used for the research of erectile dysfunction .

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9

Phentolamine hydrochloride

9 Publications Verification

Cat. No.: HY-12717A

CAS No.: 73-05-2

Purity: 99.87%

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease Endocrinology

Phentolamine hydrochloride is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine hydrochloride antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine hydrochloride reduces systemic vascular resistance and increases cardiac output. Phentolamine hydrochloride improves erectile dysfunction. Phentolamine hydrochloride can be used for the research of erectile dysfunction .

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2

Bleximenib

2 Cited Publications

Cat. No.: HY-148669

CAS No.: 2654081-35-1

Purity: 99.05%

Synonyms: JNJ-75276617; Menin-MLL inhibitor 24

Target:

Apoptosis Histone Methyltransferase FLT3

Research Areas:

Cancer

Bleximenib (JNJ-75276617) is an orally active and selective menin-KMT2A inhibitor, with IC₅₀ values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib can be used in the research of tumors such as leukemia .

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2

Bleximenib oxalate

2 Cited Publications

Cat. No.: HY-148669A

CAS No.: 2866179-95-3

Purity: ≥98.0%

Synonyms: JNJ-75276617 oxalate; Menin-MLL inhibitor 24 oxalate

Target:

Apoptosis Histone Methyltransferase FLT3

Research Areas:

Cancer

Bleximenib (JNJ-75276617) oxalate is an orally active and selective menin-KMT2A inhibitor, with IC₅₀ values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib oxalate can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib oxalate can be used in the research of tumors such as leukemia .

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1

Afoxolaner

1 Cited Publications

Cat. No.: HY-16974

CAS No.: 1093861-60-9

Target:

GABA Receptor Chloride Channel Parasite

Research Areas:

Infection

Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod .

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