54

Methyllycaconitine citrate

54 Publications Verification

Cat. No.: HY-N2332A

CAS No.: 351344-10-0

Synonyms: MLA citrate

Target:

nAChR Autophagy Reactive Oxygen Species (ROS) mTOR

Research Areas:

Neurological Disease

Methyllycaconitine (MLA) citrate is a blood-brain barrier-permeable antagonist of α7 nicotinic acetylcholine receptor (α7nAChR) with an IC₅₀ of 2 nM. Methyllycaconitine citrate inhibits Aβ_25-35-induced autophagy by restoring the mTOR pathway, and prevents reactive oxygen species (ROS) production, microglial activation, reduced dopamine uptake, loss of dopaminergic terminals and catecholamine secretion. Methyllycaconitine citrate induces hippocampal glutamate efflux, enhances long-term potentiation, and improves memory acquisition. Methyllycaconitine citrate can be used in research related to Alzheimer's disease, cerebral palsy, Parkinson's disease and schizophrenia .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

8

Clorgyline hydrochloride

8 Cited Publications

Cat. No.: HY-14197A

CAS No.: 17780-75-5

Purity: 99.92%

Synonyms: M&B 9302 hydrochloride

Target:

Monoamine Oxidase 5-HT Receptor Bcl-2 Family

Clorgyline hydrochloride (M&B 9302 hydrochloride) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline hydrochloride regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline hydrochloride induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline hydrochloride is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

8

Clorgyline

8 Cited Publications

Cat. No.: HY-14197

CAS No.: 17780-72-2

Purity: 99.76%

Synonyms: M&B 9302

Target:

Monoamine Oxidase 5-HT Receptor Bcl-2 Family

Research Areas:

Neurological Disease Metabolic Disease Cancer

Clorgyline (M&B 9302) is a selective, irreversible monoamine oxidase A (MAO-A) inhibitor that can cross the blood-brain barrier and exhibits activity against the 5-HT Receptor at very high doses. Clorgyline regulates monoamine neurotransmitter levels, the release of dopamine and acetylcholine, the uptake and effects of Tyramine (HY-W007606), noradrenergic function, circadian locomotor activity rhythms, feeding behavior, and body weight. Clorgyline induces tumor-suppressive transcriptional programs, secretory differentiation, androgen signaling regulation, Bcl-2 expression, and radioprotective effects in non-malignant cells. Clorgyline is used in the research of high-grade prostate cancer, Huntington's disease, major affective disorder, radiation-induced normal tissue toxicity, and obesity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

Nomifensine

6 Cited Publications

Cat. No.: HY-B1110

CAS No.: 24526-64-5

Synonyms: (±)-Nomifensine; Nomifensin

Target:

Dopamine Receptor Adrenergic Receptor

Research Areas:

Neurological Disease

Nomifensine ((±)-Nomifensine) is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine has antidepressant and analgesic effects. Nomifensine is used in neurodegenerative diseases, compound addiction, and pain research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

Nomifensine maleate

6 Cited Publications

Cat. No.: HY-B1110A

CAS No.: 32795-47-4

Synonyms: (±)-Nomifensine maleate; Nomifensin maleate

Target:

Dopamine Receptor Adrenergic Receptor

Research Areas:

Neurological Disease

Nomifensine ((±)-Nomifensine) maleate is a potent norepinephrine (NE) and dopamine (DA) reuptake inhibitor. Nomifensine maleate inhibits uptake of NE, DA and 5-HT in rat brain synaptosomes, with IC₅₀ values of 6.6 nM, 48 nM and 830 nM, and K_i values of 4.7 nM, 26 nM and 4000 nM, respectively. Nomifensine maleate has antidepressant and analgesic effects. Nomifensine maleate is used in neurodegenerative diseases, compound addiction, and pain research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Benztropine mesylate

5 Cited Publications

Cat. No.: HY-B0520A

CAS No.: 132-17-2

Synonyms: Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate

Target:

Dopamine Receptor mAChR Histamine Receptor

Research Areas:

Infection Neurological Disease Metabolic Disease Cancer

Benztropine mesylate (Benzatropine mesylate) is an orally active and BBB-permeable centrally acting anticholinergic agent that can be used for Parkinson's disease research. Benztropine mesylate is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine mesylate is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Benztropine

5 Cited Publications

Cat. No.: HY-B0520

CAS No.: 86-13-5

Synonyms: Benzatropine; Benzotropine

Target:

Dopamine Receptor mAChR Histamine Receptor

Research Areas:

Cancer

Benztropine (Benzatropine; Benzotropine) is an orally active and BBB-permeable centrally acting anticholinergic agent that can be used for Parkinson's disease research . Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D₂ dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

Oxolinic acid

3 Cited Publications

Cat. No.: HY-B1002

CAS No.: 14698-29-4

Target:

Bacterial Antibiotic DNA/RNA Synthesis

Research Areas:

Infection

Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

AHN 1-055 hydrochloride

3 Cited Publications

Cat. No.: HY-101315

CAS No.: 202646-03-5

Purity: 99.96%

Synonyms: 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride

Target:

Dopamine Transporter

Research Areas:

Neurological Disease

AHN 1-055 hydrochloride is a dopamine uptake inhibitor that can cross the blood-brain barrier, with an IC₅₀ of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

Tetrabenazine

1 Cited Publications

Cat. No.: HY-B0590

CAS No.: 58-46-8

Synonyms: Ro 1-9569

Target:

Monoamine Transporter Dopamine Receptor

Research Areas:

Neurological Disease

Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 K_i 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .

Compare

loading...