12

FKBP12 PROTAC dTAG-13

12 Publications Verification

Cat. No.: HY-114421

CAS No.: 2064175-41-1

Purity: 99.89%

Synonyms: dTAG-13

Target:

PROTACs FKBP Pregnane X Receptor (PXR)

Research Areas:

Cancer

FKBP12 PROTAC dTAG-13 (dTAG-13) is a FKBP12 ^F36V PROTAC degrader and a PXR partial agonist. FKBP12 PROTAC dTAG-13 induces ubiquitination and proteasomal degradation of proteins tagged with FKBP12 ^F36V, without degrading wild-type FKBP12 or un-fused PXR. It weakly promotes the recruitment of SRC-1, strongly inhibits the interaction between NCoR and PXR, and upregulates the expression of CYP3A4 and other drug metabolism-related genes. FKBP12 PROTAC dTAG-13 is applicable to research related to breast cancer and leukemia ^[1] .

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2

Praziquantel

2 Cited Publications

Cat. No.: HY-B0244

CAS No.: 55268-74-1

Target:

Parasite Antibiotic

Research Areas:

Infection

Praziquantel is a broadly effective trematocide and cestocide, the initial effect of praziquantel on the schistosome may be an interaction of the drug with lipid constituents of the tegumental membrane. Praziquantel is used for the research of schistosomiasis .

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2

TAT-GluA2 3Y

2 Cited Publications

Cat. No.: HY-P2259

CAS No.: 1404188-93-7

Target:

iGluR HIV Integrase Adenosine Receptor

Research Areas:

Cardiovascular Disease Neurological Disease

TAT-GluA2 3Y is a blood-brain barrier-permeable AMPA receptor inhibitory peptide that crosses cell membranes via the HIV-1 TAT protein domain. TAT-GluA2 3Y blocks the endocytosis of AMPA receptors, including the internalization of GluA1/GluA2 subunits, by disrupting interactions with the AP2, Brag2 and Syt3-GluA2 complexes, while also inhibiting long-term depression. TAT-GluA2 3Y blocks hypoxia-mediated AMPAR internalization, alleviates A1R-induced persistent synaptic inhibition, and reduces cerebral ischemic volume, neurological deficits and spatial memory deficits. TAT-GluA2 3Y blocks the effect of NLRP3 deficiency on fear generalization, inhibits amphetamine-induced behavioral/neurochemical sensitization, weakens the unconditioned stimulus-conditioned stimulus association of morphine, and promotes the extinction of morphine CPP. TAT-GluA2 3Y can be used in studies related to fear generalization, ischemic stroke, hypoxia, drug addiction and opioid addiction .

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1

K67

1 Cited Publications

Cat. No.: HY-111126

CAS No.: 2046250-48-8

Purity: 98.26%

Target:

p62 Keap1-Nrf2

Research Areas:

Cancer

K67 is a selective the interaction between Keap1 and S349 phosphorylated p62 inhibitor, with an IC₅₀ of 1.5 μM. K67 has a weaker inhibitory effect on the interaction between Keap1 and Nrf2 (IC₅₀ is 6.2 μM). K67 competitively binds to the binding site of Keap1 with p-p62, blocking the abnormal activation of the p62-dependent Nrf2 pathway. K67 inhibits tumor cell proliferation and enhances the sensitivity of hepatocellular carcinoma (HCC) to chemotherapeutic drugs by restoring Keap1-mediated ubiquitination and degradation of Nrf2 .

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1

DPI-4452

1 Cited Publications

Cat. No.: HY-P10761

CAS No.: 2941391-49-5

Target:

Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase

Research Areas:

Cancer

DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC₅₀ for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

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1

3-Methyluridine

1 Cited Publications

Cat. No.: HY-113138

CAS No.: 2140-69-4

Purity: 99.05%

Synonyms: N3-Methyluridine

Category:

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite

3-Methyluridine (m ³U; N3-Methyluridine) is a methylated nucleotide present in ribosomal RNA (rRNA), mainly targeting specific base sites of RNA molecules such as 23S rRNA. 3-Methyluridine can introduce a methyl group at the N3 position of uracil, affecting the secondary structure stability and base pairing ability of RNA, and regulating ribosome function. For example, it affects ribosomal subunit binding and tRNA interaction. 3-Methyluridine is often used as a key raw material for the synthesis of modified nucleotides, and is used to construct RNA oligonucleotides containing methylation modifications to study the effects of RNA methylation on gene expression and drug resistance .

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