213

Temozolomide

213 Publications Verification

Cat. No.: HY-17364

CAS No.: 85622-93-1

Synonyms: NSC 362856; CCRG 81045; TMZ

Target:

DNA Alkylator/Crosslinker Autophagy Apoptosis

Research Areas:

Cancer

Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

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179

Vorinostat

179 Cited Publications

Cat. No.: HY-10221

CAS No.: 149647-78-9

Purity: 99.58%

Synonyms: SAHA; Suberoylanilide hydroxamic acid

Target:

HDAC Autophagy Mitophagy Filovirus Apoptosis HPV

Research Areas:

Infection Cancer

Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID₅₀ values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis . Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification .

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92

Crizotinib

92 Cited Publications

Cat. No.: HY-50878

CAS No.: 877399-52-5

Synonyms: PF-02341066

Target:

Ligands for Target Protein for PROTAC Anaplastic lymphoma kinase (ALK) c-Met/HGFR ROS Kinase

Research Areas:

Cancer

Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition .

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92

Crizotinib hydrochloride

92 Cited Publications

Cat. No.: HY-50878A

CAS No.: 1415560-69-8

Synonyms: PF-02341066 hydrochloride

Target:

Anaplastic lymphoma kinase (ALK) c-Met/HGFR ROS Kinase Autophagy

Research Areas:

Cancer

Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC₅₀s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC₅₀s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition .

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59

Nystatin

59 Cited Publications

Cat. No.: HY-17409

CAS No.: 1400-61-9

Category:

Infection Microorganisms Macrolide Antibiotics Antifungal Antibiotics Mammalian Cell Culture Disease Research Disease Research Fields

Target:

Fungal Antibiotic Apoptosis Bacterial

Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma. Nystatin increases the permeability of plasma membranes to small monovalent ions, including chloridion . Nystatin is a cholesterol-sequestering agent , partially prevents Oxaliplatin-induced lipid raft aggregation, DR4 and DR5 clustering, and thereby reduces apoptosis .

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54

NAD sodium

54 Cited Publications

Cat. No.: HY-B0445A

CAS No.: 20111-18-6

Synonyms: β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium

NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .

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47

Alectinib

47 Cited Publications

Cat. No.: HY-13011

CAS No.: 1256580-46-7

Purity: 99.78%

Synonyms: CH5424802; RO5424802; RG7853

Target:

Anaplastic lymphoma kinase (ALK)

Research Areas:

Neurological Disease Cancer

Alectinib (CH5424802; RO5424802; RG7853) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a K_d value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively . Alectinib demonstrates effective central nervous system (CNS) penetration .

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47

Alectinib Hydrochloride

47 Cited Publications

Cat. No.: HY-13011A

CAS No.: 1256589-74-8

Purity: 99.92%

Synonyms: CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride

Target:

Anaplastic lymphoma kinase (ALK)

Research Areas:

Neurological Disease Cancer

Alectinib (CH5424802; RO5424802; RG7853) Hydrochloride is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a K_d value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively . Alectinib demonstrates effective central nervous system (CNS) penetration .

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29

AZD9496

29 Cited Publications

Cat. No.: HY-12870

CAS No.: 1639042-08-2

Purity: 99.28%

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

AZD9496 is an effective, selective estrogen receptor (ERα) antagonist with an IC₅₀ of 0.28 nM. AZD9496 is an orally active, selective estrogen receptor degrader (SERD).

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23

Moxifloxacin hydrochloride monohydrate

23 Cited Publications

Cat. No.: HY-W353258

CAS No.: 192927-63-2

Synonyms: BAY 12-8039 monohydrate

Moxifloxacin (BAY 12-8039) hydrochloride monohydrate is an orally active bacterial inhibitor that is effective against Streptococcus pneumoniae. Moxifloxacin hydrochloride monohydrate can be used in tuberculosis research .

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21

Astaxanthin

21 Cited Publications

Cat. No.: HY-B2163

CAS No.: 472-61-7

Category:

Cardiovascular Disease Anti-aging Whitening Agent Research on Agricultural Breeding Food Research Agricultural Research Microorganisms Sunscreen Terpenoids Pigments Diterpenoids Cosmetic Research Disease Research Fields

Target:

PPAR Reactive Oxygen Species (ROS) STAT NF-κB Apoptosis

Astaxanthin, the red dietary carotenoid, is an orally effective and potent antioxidant. Astaxanthin inhibits NF-κB and down-regulates VEGF in blood glucose. Astaxanthin exerts anti-cancer cell proliferation, increases apoptosis, impairs migration and invasion by activating PPARγ and reducing the expression of STAT3. Astaxanthin also has neuroprotective and anti-inflammatory activity and can be used in studies of cancer, diabetic retinopathy, cardiovascular disease, and in the coloring of animal feed .

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21

Miransertib

21 Cited Publications

Cat. No.: HY-19719

CAS No.: 1313881-70-7

Synonyms: ARQ-092

Target:

Akt Parasite

Research Areas:

Infection Cancer

Miransertib (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC₅₀s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. Miransertib is also a potent the AKT1-E17K mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research . Miransertib is effective against Leishmania .

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21

Miransertib hydrochloride

21 Cited Publications

Cat. No.: HY-19719A

CAS No.: 1313883-00-9

Synonyms: ARQ-092 hydrochloride

Target:

Akt Parasite

Research Areas:

Infection Cancer

Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC₅₀s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. Miransertib hydrochloride is also a potent the AKT1-E17K mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research . Miransertib hydrochloride is effective against Leishmania .

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17

TFEB activator 1

17 Cited Publications

Cat. No.: HY-135825

CAS No.: 39777-61-2

Purity: 99.71%

Target:

Autophagy

Research Areas:

Neurological Disease

TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC₅₀ of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment .

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14

Iptacopan

14 Cited Publications

Cat. No.: HY-127105

CAS No.: 1644670-37-0

Purity: 99.93%

Synonyms: LNP023

Target:

Complement System

Research Areas:

Metabolic Disease Inflammation/Immunology

Iptacopan (LNP023) is an effective and orally-active highly selective factor B inhibitor with an IC₅₀ value of 10 nM and K_D of 7.9 nM. Iptacopan exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .

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14

Iptacopan hydrochloride

14 Cited Publications

Cat. No.: HY-127105A

CAS No.: 1646321-63-2

Purity: 99.83%

Synonyms: LNP023 hydrochloride

Target:

Complement System

Research Areas:

Metabolic Disease Inflammation/Immunology

Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC₅₀ value of 10 nM and K_D of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .

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13

Xevinapant hydrochloride

13 Cited Publications

Cat. No.: HY-13208

CAS No.: 1071992-57-8

Purity: 98.01%

Synonyms: AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride

Target:

IAP Apoptosis

Research Areas:

Cancer

Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with K_is of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors .

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12

Abrocitinib

12 Cited Publications

Cat. No.: HY-107429

CAS No.: 1622902-68-4

Purity: 99.26%

Synonyms: PF-04965842

Target:

JAK

Research Areas:

Inflammation/Immunology

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC₅₀s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC₅₀, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease .

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11

Medroxyprogesterone

11 Cited Publications

Cat. No.: HY-B0648

CAS No.: 520-85-4

Synonyms: 17α-Hydroxy-6α-methylprogesterone; U8840

Target:

Progesterone Receptor

Research Areas:

Endocrinology Cancer

Medroxyprogesterone (17α-Hydroxy-6α-methylprogesterone) is a synthetic human variant of progesterone that is a progesterone receptor agonist with oral activity. Medroxyprogesterone can induce cell proliferation through the PI3K/Akt signaling pathway. Medroxyprogesterone has an inhibitory effect on atherosclerosis in mice. The progesterone agonist activity of Medroxyprogesterone is less effective than Medroxyprogesterone acetate (HY-B0469) .

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