2

2 Cited Publications

Target:

Research Areas:

Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis .

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Lipoxin A4

2 Cited Publications

Cat. No.: HY-113509

CAS No.: 89663-86-5

Purity: 98.0%

Synonyms: LXA4

Category:

Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

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1

KT109

1 Cited Publications

Cat. No.: HY-18540

CAS No.: 1402612-55-8

Target:

MAGL DAGL

Research Areas:

Metabolic Disease Inflammation/Immunology

KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .

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Leukotriene C4

Cat. No.: HY-113446

CAS No.: 72025-60-6

Purity: ≥95.0%

Category:

Infection Natural Products Immune System Disorder Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Inflammation/Immunology Cardiovascular System Disorder

Target:

Endogenous Metabolite

Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage .

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Peptone from soya

Cat. No.: HY-W133891

CAS No.: 91079-46-8

Synonyms: Peptones, soybean

Peptone from soy (peptones, soybean) is a peptone. Peptone from soy provides nitrogen and carbon sources, as well as other nutrients. Peptone from soy can stimulate/regulate the biosynthesis of cyclic eicosanoids. Peptone from soy induces dose-dependent contraction of guinea pig lung parenchyma. Peptone from soy can be used in microbial and cell culture .

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Prostaglandin E3

Cat. No.: HY-113481

CAS No.: 802-31-3

Target:

Transmembrane Glycoprotein COX PKA Prostaglandin Receptor

Research Areas:

Inflammation/Immunology Cancer

Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity .

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Methyl arachidonate

Cat. No.: HY-W011297

CAS No.: 2566-89-4

Synonyms: Arachidonic acid methyl ester

Target:

PKC

Research Areas:

Metabolic Disease

Methyl arachidonate is a protein kinase C activator and also an orally active substrate that undergoes esterase-mediated hydrolysis. Methyl arachidonate indirectly activates protein kinase C via eicosanoid metabolites generated through the arachidonic acid metabolic pathway, exerting effects via cyclooxygenase products at low concentrations and via lipoxygenase products at high concentrations. Methyl arachidonate can be used in studies related to lipodystrophy .

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(R)-KT109

Cat. No.: HY-126031

CAS No.: 2055172-60-4

Target:

DAGL

Research Areas:

Inflammation/Immunology

(R)-KT109 is a peripherally restricted serine hydrolase inhibitor that cannot cross the blood-brain barrier. (R)-KT109 irreversibly inhibits ABHD6, DAGLα and DAGLβ via carbamoylation of the active-site serine. (R)-KT109 exerts selective inhibitory effects on serine hydrolases in mouse brains, with pIC₅₀ values of 8.6, 9.1 and 8.2 against human ABHD6, DAGLα and DAGLβ, respectively. (R)-KT109 effectively reduces the levels of 2-arachidonoylglycerol, arachidonic acid, eicosanoids and TNF-α. (R)-KT109 is widely used in studies of metabolic syndrome-related diseases and neuroinflammation .

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Thromboxane B3

Cat. No.: HY-113445

CAS No.: 71953-80-5

Purity: ≥95.0%

Target:

Endogenous Metabolite

Research Areas:

Metabolic Disease Cancer

Thromboxane B3 is an eicosanoid and the stable hydrolysis product of thromboxane A3, which is synthesized from eicosapentaenoic acid by cyclooxygenase (COX) and thromboxane synthase. Thromboxane B3 participates in inflammatory cell regulation, tumorigenesis and cell proliferation processes. Elevated levels of Thromboxane B3 correlate with high-risk regions of esophageal cancer. Thromboxane B3 can be used in studies related to bladder cancer, renal cell carcinoma and esophageal squamous cell carcinoma .

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1,2-Dilignoceroyl-sn-glycero-3-phosphocholine

Cat. No.: HY-W725399

CAS No.: 91742-11-9

Synonyms: DLiPC; PC24

Target:

Drug Intermediate Endogenous Metabolite

Research Areas:

Others

1,2-Dilignoceroyl-sn-glycero-3-phosphocholine (DLiPC) is a long-chain diacyl phospholipid characterized by its C24 saturated hydrocarbon chains and serves as a significant precursor for eicosanoids.

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8(S),9(R)-EET

Cat. No.: HY-150092

CAS No.: 123931-39-5

Category:

Ketones, Aldehydes, Acids Endogenous metabolite

Target:

Drug Metabolite

8(S),9(R)-EET is an eicosanoid product of Arachidonic acid (AA; HY-109590) by cytochromes P450. 8(S),9(R)-EET dilates canine epicardial arterioles in a concentration-dependent manner with an EC₅₀ value of 121 nM .

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Dihomo-γ-Linolenic acid methyl ester

Cat. No.: HY-116015

CAS No.: 21061-10-9

Purity: 98.00%

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite

Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic Acid (DGLA) (HY-A0143). Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is metabolized mainly through the cyclooxygenase (COX) pathway to the anti-inflammatory eicosanoid prostaglandin (PG) E1. Dihomo-γ-Linolenic acid has anti-inflammatory and antiproliferation effects .

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