252 Results for "

entorhinal cortex

" in MedChemExpress (MCE) Product Catalog:
Products (252)

252 Results for "entorhinal cortex" in MCE Product Catalog:

95
Hydrocortisone
Hydrocortisone
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95 Publications Verification
Cat. No.: HY-N0583
CAS No.: 50-23-7
Synonyms: Cortisol
Category:  

Endogenous metabolite Disease Research Fields Endocrinology Cancer Steroids

Target:  

Environmental Pollutants Endogenous Metabolite Glucocorticoid Receptor

Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex .
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72
Corticosterone
Corticosterone
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72 Cited Publications
Cat. No.: HY-B1618
CAS No.: 50-22-6
Synonyms: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B
Category:  

Neurological Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:  

Glucocorticoid Receptor Endogenous Metabolite iGluR

Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect .
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33
1400W
1400W
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33 Cited Publications
Cat. No.: HY-18730
CAS No.: 180001-34-7
Synonyms: W1400
Target:  

NO Synthase Apoptosis

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .
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33
1400W Dihydrochloride
1400W Dihydrochloride
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33 Cited Publications
Cat. No.: HY-18731
CAS No.: 214358-33-5
Target:  

NO Synthase Apoptosis

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation .
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11
Aldosterone
Aldosterone
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11 Cited Publications
Cat. No.: HY-113313
CAS No.: 52-39-1
Purity:  98.93%
Category:  

Cardiovascular Disease Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite

Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level .
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10
L-Tyrosine
L-Tyrosine
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10 Cited Publications
Cat. No.: HY-N0473
CAS No.: 60-18-4
Synonyms: Tyrosine
Category:  

Microorganisms Neurological Disease Anti-aging Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
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7
Spironolactone
Spironolactone
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7 Cited Publications
Cat. No.: HY-B0561
CAS No.: 52-01-7
Synonyms: SC9420
Target:  

Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel

Research Areas:  

Cardiovascular Disease Metabolic Disease Endocrinology Cancer

Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects .
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5
Fraxin
Fraxin
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5 Cited Publications
Cat. No.: HY-N0579
CAS No.: 524-30-1
Synonyms: Fraxoside
Category:  

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