190

Decitabine

190 Publications Verification

Cat. No.: HY-A0004

CAS No.: 2353-33-5

Synonyms: 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716

Target:

DNA Methyltransferase Apoptosis Nucleoside Antimetabolite/Analog

Research Areas:

Infection Inflammation/Immunology Cancer

Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell Apoptosis. Decitabine has potent anticancer activity .

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135

Imatinib

135 Cited Publications

Cat. No.: HY-15463

CAS No.: 152459-95-5

Purity: 99.95%

Synonyms: STI571; CGP-57148B

Target:

Bcr-Abl PDGFR c-Kit SARS-CoV Autophagy

Research Areas:

Cancer

Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively . Imatinib also is an inhibitor of SARS-CoV and MERS-CoV .

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118

Talazoparib

118 Cited Publications

Cat. No.: HY-16106

CAS No.: 1207456-01-6

Synonyms: BMN-673; LT-673

Target:

PARP

Research Areas:

Cancer

Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with K_is of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity .

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84

Pronase E (Activity ≥ 7000 U/g)

84 Cited Publications

Cat. No.: HY-114158

CAS No.: 9036-06-0

Synonyms: Pronase (activity ≥ 7000 U/g)

Category:

Natural Products Microorganisms Other Diseases Disease Research Fields

Target:

Others

Pronase E (Activity ≥ 7000 U/g) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids .

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64

Ammonium chloride, for cell culture

64 Cited Publications

Cat. No.: HY-Y1269C

CAS No.: 12125-02-9

Synonyms: Salmiac, for cell culture

Ammonium chloride, for cell culture (Salmiac, for cell culture) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.Ammonium chloride is also a lysosome inhibitor.

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55

Favipiravir

55 Cited Publications

Cat. No.: HY-14768

CAS No.: 259793-96-9

Purity: 99.97%

Synonyms: T-705

Target:

DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial

Research Areas:

Infection

Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

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51

DNase I (filtered)

51 Cited Publications

Cat. No.: HY-108882C

CAS No.: 9003-98-9

Target:

DNA/RNA Synthesis

Research Areas:

Inflammation/Immunology

DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune reactions. Decreased DNase I activity may be associated with the occurrence and development of systemic lupus erythematosus (SLE). DNase I (filtered) is filtered through a 0.22 μM membrane and is not tested for pyrogenicity .

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51

DNase I RNase & Protease free

51 Cited Publications

Cat. No.: HY-108882B

CAS No.: 9003-98-9

Target:

DNA/RNA Synthesis

Research Areas:

Inflammation/Immunology

DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune responses. Decreased DNase I activity may be associated with the onset and progression of systemic lupus erythematosus (SLE). DNase I (RNase & Protease free) is a molecular biology-grade DNase I purified by chromatography to remove RNase and protease .

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46

Citric acid

46 Cited Publications

Cat. No.: HY-N1428

CAS No.: 77-92-9

Category:

Cardiovascular Disease Preservatives Anti-aging Metabolic Disease Endocrine diseases Endogenous metabolite Food Research Infection Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer

Target:

Environmental Pollutants Endogenous Metabolite Bacterial Apoptosis

Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .

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42

Talabostat mesylate

42 Cited Publications

Cat. No.: HY-13233A

CAS No.: 150080-09-4

Purity: 98.35%

Synonyms: Val-boroPro mesylate; PT100 mesylate

Target:

Dipeptidyl Peptidase

Research Areas:

Inflammation/Immunology Cancer

Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC₅₀ < 4 nM; K_i = 0.18 nM) and the inhibitor of fibroblast activation protein (FAP) (IC₅₀ = 560 nM), inhibits DPP8/9 (IC₅₀ = 4/11 nM; K_i = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC₅₀ = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities .

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39

Temuterkib

39 Cited Publications

Cat. No.: HY-101494

CAS No.: 1951483-29-6

Purity: 99.94%

Synonyms: LY3214996

Target:

ERK

Research Areas:

Cancer

Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC₅₀ of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.

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34

Boceprevir

34 Cited Publications

Cat. No.: HY-10237

CAS No.: 394730-60-0

Purity: 98.52%

Synonyms: EBP 520; SCH 503034

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a K_i of 14 nM in both enzyme assay and an EC₉₀ of 350 nM in cell-based replicon assay . Boceprevir inhibits SARS-CoV-2 3CL ^pro activity .

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33

Relebactam

33 Cited Publications

Cat. No.: HY-16752

CAS No.: 1174018-99-5

Synonyms: MK-7655

Target:

Beta-lactamase Bacterial

Research Areas:

Infection

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity .

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29

Pronase E (Activity ≥ 4000 U/mg)

29 Cited Publications

Cat. No.: HY-114158A

CAS No.: 9036-06-0

Synonyms: Pronase (activity ≥ 4000 U/mg)

Category:

Natural Products Microorganisms Other Diseases Disease Research Fields

Target:

Others

Pronase E (Activity ≥ 4000 U/mg) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids .

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27

PYR-41

27 Cited Publications

Cat. No.: HY-13296

CAS No.: 418805-02-4

Purity: ≥98.0%

Target:

E1/E2/E3 Enzyme Apoptosis

Research Areas:

Cancer

PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC₅₀ of < 10 μM, with little activity at E2 and E3.

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27

Abiraterone

27 Cited Publications

Cat. No.: HY-70013

CAS No.: 154229-19-3

Synonyms: CB-7598

Target:

Cytochrome P450

Research Areas:

Cancer

Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity, which inhibits both the 17α-hydroxylase and 17,20-lyase activity of the cytochrome p450 enzyme CYP17 with IC₅₀s of 2.5 nM and 15 nM, respectively.

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27

Beta-Sitosterol (purity>80%)

27 Cited Publications

Cat. No.: HY-N0171

CAS No.: 83-46-5

Category:

Endogenous metabolite

Target:

Apoptosis Endogenous Metabolite

Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

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27

Beta-Sitosterol (purity>98%)

27 Cited Publications

Cat. No.: HY-N0171A

CAS No.: 83-46-5

Synonyms: β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)

Category:

Steroids

Target:

Bacterial Apoptosis Reactive Oxygen Species (ROS) MDM-2/p53 Caspase PARP MMP Bcl-2 Family HIF/HIF Prolyl-Hydroxylase TNF Receptor Interleukin Related NF-κB mTOR Lactate Dehydrogenase CDK Glutathione Peroxidase SOD

Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered Bcl-2-Bax ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc .

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24

Ivosidenib

24 Cited Publications

Cat. No.: HY-18767

CAS No.: 1448347-49-6

Synonyms: AG-120

Target:

Isocitrate Dehydrogenase (IDH)

Research Areas:

Infection Metabolic Disease Cancer

Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity .

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