145

5-Azacytidine

145 Publications Verification

Cat. No.: HY-10586

CAS No.: 320-67-2

Purity: 99.91%

Synonyms: Azacitidine; 5-AzaC; Ladakamycin

Target:

Organoid Nucleoside Antimetabolite/Analog DNA Methyltransferase Bacterial Autophagy Antibiotic

Research Areas:

Infection Cancer

5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes . 5-Azacytidine induces cell autophagy .

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73

Lactic acid

73 Cited Publications

Cat. No.: HY-B2227

CAS No.: 50-21-5

Synonyms: DL-Lactic acid; E-270

Category:

Human Gut Microbiota Metabolites Anti-aging Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:

Environmental Pollutants Endogenous Metabolite Bacterial Hydroxycarboxylic Acid Receptor (HCAR)

Lactic acid (DL-Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid also has antimicrobial activity, which can be used as a food preservative .

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72

Lactic acid potassium

72 Cited Publications

Cat. No.: HY-B2227C

CAS No.: 996-31-6

Synonyms: DL-Lactic acid potassium; E-270 potassium

Target:

Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR) Bacterial

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

Lactic acid (DL-Lactic acid) potassium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid potassium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid potassium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid also potassium has antimicrobial activity, which can be used as a food preservative .

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72

Lactic acid calcium

72 Cited Publications

Cat. No.: HY-B2227A

CAS No.: 814-80-2

Synonyms: DL-Lactic acid calcium; E-270 calcium

Target:

Endogenous Metabolite Bacterial Hydroxycarboxylic Acid Receptor (HCAR)

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Lactic acid (DL-Lactic acid) calcium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid calcium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid calcium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid calcium also has antimicrobial activity, which can be used as a food preservative .

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72

Lactic acid sodium (60% w/w in water)

72 Cited Publications

Cat. No.: HY-B2227B

CAS No.: 72-17-3

Synonyms: DL-Lactic acid sodium; E-270 sodium

Target:

Environmental Pollutants Endogenous Metabolite Bacterial Hydroxycarboxylic Acid Receptor (HCAR)

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .
This product has a content (w/w) of 60%, and 1 mL of the system contains 798 mg of Lactic acid sodium, i.e., a concentration of 798 mg/mL (i.e., 7.12 M).

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30

Bobcat339

30 Cited Publications

Cat. No.: HY-111558

CAS No.: 2280037-51-4

Purity: 99.44%

Target:

DNA Methyltransferase TET Protein

Research Areas:

Cancer

Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC₅₀s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription .

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30

Bobcat339 hydrochloride

30 Cited Publications

Cat. No.: HY-111558A

CAS No.: 2436747-44-1

Purity: 99.59%

Target:

DNA Methyltransferase TET Protein

Research Areas:

Cancer

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC₅₀s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription .

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24

Calcium 2-hydroxypropanoate pentahydrate

24 Cited Publications

Cat. No.: HY-B2227D

CAS No.: 5743-47-5

Calcium 2-hydroxypropanoate (pentahydrate) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Calcium 2-hydroxypropanoate (pentahydrate) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Calcium 2-hydroxypropanoate (pentahydrate) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .

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22

RRx-001

22 Cited Publications

Cat. No.: HY-16438

CAS No.: 925206-65-1

Synonyms: Nibrozetone

Target:

CD47 Apoptosis Parasite

Research Areas:

Infection Inflammation/Immunology Cancer

RRx-001, a hypoxia-selective epigenetic agent and studied as a radio- and chem-sensitizer, triggers apoptosis and overcomes agent resistance in myeloma. RRx-001 exhibits potent anti-tumor activity with minimal toxicity . RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α . RRx-001 is a potent inhibitor of G6PD and shows potent antimalarial activity .

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12

UNC0638

12 Cited Publications

Cat. No.: HY-15273

CAS No.: 1255580-76-7

Purity: 99.48%

Target:

VSV Histone Methyltransferase Autophagy Influenza Virus

Research Areas:

Infection Cancer

UNC0638, a chemical probe, selectively inhibits G9a and GLP histone methyltransferases with IC₅₀ of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets .

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7

Oxybenzone

7 Cited Publications

Cat. No.: HY-A0067

CAS No.: 131-57-7

Synonyms: Benzophenone 3

Target:

Environmental Pollutants Autophagy RAR/RXR Apoptosis

Research Areas:

Neurological Disease

Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .

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