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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
98 Results for "
epithelium
" in MedChemExpress (MCE) Product Catalog:
Products (98)
98 Results for "epithelium" in MCE Product Catalog:
11
11 Publications Verification
Synonyms: Prostaglandin F2α; PGF2α
11
11 Publications Verification
Synonyms: Prostaglandin F2α tromethamine salt; PGF2α THAM; Prostaglandin F2α THAM
10
10 Cited Publications
Cat. No.: HY-116282C
CAS No.: 9011-18-1
Synonyms: DSS (MW 35000-45000); DXS (MW 35000-45000)
Target:
Research Areas:
Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a polymer of dehydrated glucose with a molecular weight of approximately 35000-45000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 35000-45000) is a potent inducer of colitis. Dextran sulfate sodium salt (DSS) (MW 35000-45000) can be used to induce model acute colitis, chronic colitis, and colitis-related colon cancer. Dextran sulfate sodium salt (DSS) (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium .
7
7 Cited Publications
Synonyms: GDC-9545; RG6171
Target:
Research Areas:
Giredestrant (GDC-9545) is an orally active, full, selective Estrogen receptor α (ERα) degrader and antagonist with a DC50 of 0.03 nM. Giredestrant promotes the degradation of ERα protein, including the ESR1 Y537S mutant ERα. Giredestrant reduces uterine wet weight in immature rats and induces a low cuboidal phenotype in their endometrial epithelium. Giredestrant induces tumor regression in both ESR1 Y537S mutant and wild-type ERα tumor models. Giredestrant can be used for the research of ER + breast cancer .
5
5 Cited Publications
Synonyms: Sodium decanoate; Sodium caprate
5
5 Cited Publications
Cat. No.: HY-78726
CAS No.: 226700-79-4
Synonyms: Amprenavir phosphate; GW 433908
Target:
Research Areas:
Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .
5
Target:
Research Areas:
Fosamprenavir Calcium Salt (GW433908G) is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir Calcium Salt is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir Calcium Salt can be used for the study of human immunodeficiency virus (HIV-1) infection .
3
3 Cited Publications
Synonyms: Tris; Tris(hydroxymethyl)aminomethane
Target:
Research Areas:
THAM (Tris) is a low-toxicity amino alcohol buffer, a specific CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications .
3
3 Cited Publications
Cat. No.: HY-P7054
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINF1; Testis Tissue Sperm-Binding Protein Li 70n; Prev. PEDF; Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment epithelium Derived Factor), Member 1; EPC-1; Proliferation-Inducing Protein 35; Pigment epithelium-Derived Factor; Serpin F
Species:
Human
Source:
E. coli
2
2 Cited Publications
Synonyms: A2E TFA; N-retinylidene-N-retinylethanolamine TFA
Research Areas:
Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases .
2
2 Cited Publications
Cat. No.: HY-B2184
CAS No.: 64506-49-6
Research Areas:
Sofalcone, a gastric antiulcer agent, is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
2
2 Cited Publications
Synonyms: Tris HCl (≥99%, for cell culture); Tris hydrochloride (≥99%, for cell culture)
2
2 Cited Publications
Synonyms: Tris acetate; Tris(hydroxymethyl)aminomethane acetate
Target:
Research Areas:
THAM acetate is a low-toxicity amino alcohol buffer, a CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM acetate binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM acetate may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM acetate removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM acetate can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM acetate is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications .
1
1 Cited Publications
Cat. No.: HY-P2671
CAS No.: 39024-57-2
Target:
Research Areas:
1
1 Cited Publications
Synonyms: 8-CPT-2'-O-Me-cAMP sodium
Target:
Research Areas:
8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP) sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2′-O-Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 >10 μM). 8-pCPT-2′-O-Me-cAMP sodium stimulates Epac-mediated Ca 2+ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration .
1
1 Cited Publications
Cat. No.: HY-W039865
CAS No.: 19879-84-6
1
1 Cited Publications
Cat. No.: HY-P73372
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINF1; Testis Tissue Sperm-Binding Protein Li 70n; Prev. PEDF; Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment epithelium Derived Factor), Member 1; EPC-1; Proliferation-Inducing Protein 35; Pigment epithelium-Derived Factor; Serpin F
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P70498A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINF1; Testis Tissue Sperm-Binding Protein Li 70n; Prev. PEDF; Serpin Peptidase Inhibitor, Clade F (Alpha-2 Antiplasmin, Pigment epithelium Derived Factor), Member 1; EPC-1; Proliferation-Inducing Protein 35; Pigment epithelium-Derived Factor; Serpin F
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71358A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TFPI2; Placental Protein 5; Tissue Factor Pathway Inhibitor 2; Retinal Pigment epithelium Cell Factor 1; TFPI-2; Tissue Factor Pathway Inhibitor; PP5; TFPI2 Variant; REF1
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P74527A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TFPI2; Placental Protein 5; Tissue Factor Pathway Inhibitor 2; Retinal Pigment epithelium Cell Factor 1; TFPI-2; Tissue Factor Pathway Inhibitor; PP5; TFPI2 Variant; REF1
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
