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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
erythroid differentiation
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "erythroid differentiation" in MCE Product Catalog:
9
9 Publications Verification
Research Areas:
SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer .
2
2 Cited Publications
Cat. No.: HY-P700159AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: INHBA; Follicle-Stimulating Hormone-Releasing Protein; Inhibin Subunit Beta A; erythroid differentiation Factor; Inhibin Beta A Chain; Inhibin Beta A Subunit; Activin Beta-A Chain; FSH-Releasing Protein; Inhibin, Beta A (Activin A, Activin AB Alpha Polype
Species:
Human
Rat
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P73241
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: INHBA; Follicle-Stimulating Hormone-Releasing Protein; Inhibin Subunit Beta A; erythroid differentiation Factor; Inhibin Beta A Chain; Inhibin Beta A Subunit; Activin Beta-A Chain; FSH-Releasing Protein; Inhibin, Beta A (Activin A, Activin AB Alpha Polype
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P703994
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: INHBA; Follicle-Stimulating Hormone-Releasing Protein; Inhibin Subunit Beta A; erythroid differentiation Factor; Inhibin Beta A Chain; Inhibin Beta A Subunit; Activin Beta-A Chain; FSH-Releasing Protein; Inhibin, Beta A (Activin A, Activin AB Alpha Polype
Species:
Human
Source:
HEK293
Cat. No.: HY-159520
CAS No.: 2731294-23-6
Synonyms: Ofirnoflast; HT-6184
Research Areas:
Ofirnoflastum (Ofirnoflast) is an orally active first-in-class allosteric NEK7 inhibitor with an IC50 of 46 nM. Ofirnoflastum binds an allosteric site adjacent to NEK7’s ATP-binding pocket, induces conformational shifts, disrupts NEK7-NLRP3 binding, blocks NLRP3 inflammasome assembly, spares NEK7’s physiological functions, and suppresses caspase-1, caspase-8, NF-κB, and TNF activity. Ofirnoflastum reduces pro-inflammatory cytokine production, suppresses ASC specks, IL-1β release, pyroptotic cell death, and leukemic burden, induces apoptosis and erythroid differentiation, restores hematopoiesis, and improves outcomes in colitis models. Ofirnoflastum can be used for the research of myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia .
Target:
Research Areas:
BD-9136 is a selective BRD4 PROTAC degrader with a DC50 of 1.2 nM, and exhibits a selectivity of ≥1000-fold over BRD2 and BRD3. BD-9136 preferentially forms a ternary complex with the BD1 domain of BRD4, and downregulates the expression of B7-H4 by disrupting the PR-P300-BRD4 axis. BD-9136 depletes BRD4 protein in tumor tissues, inhibits tumor growth, reduces B7-H4 protein expression, increases CD8+ T cell infiltration, and enhances tumor sensitivity to anti-PD-L1. Degradation of BRD4 by BD-9136 rescues the erythroid differentiation block induced by LSD1 inhibition, and transient administration restores erythroid output while retaining HbF induction. BD-9136 causes no adverse effects in mice at effective doses. BD-9136 can be used in studies related to acute myeloid leukemia, acute lymphoblastic leukemia and breast cancer .
Cat. No.: HY-P99720A
CAS No.: 1373715-00-4
Synonyms: RAP-536
Target:
Research Areas:
Cat. No.: HY-P3761
CAS No.: 147821-01-0
Target:
Research Areas:
Cat. No.: HY-118964
CAS No.: 151013-48-8
Tyrphostin AG 568 is a tyrphostin tyrosine kinase inhibitor that induces erythroid differentiation. Tyrphostin AG 568 can be utilized in research related to autologous bone marrow transplantation .
Cat. No.: HY-10966R
CAS No.: 405554-55-4
Target:
Research Areas:
SB-590885 (Standard) is the analytical standard of SB-590885 (HY-10966). This product is intended for research and analytical applications. SB-590885 is a BRAF/c-Raf kinase inhibitor that selectively targets B-Raf, and it amplifies the ERK/MAPK signaling pathway in RAS-activated cells. SB-590885 effectively inhibits the malignant proliferation, transformation and tumorigenicity of oncogenic B-Raf cells; it also induces the proliferation of erythroid progenitor cells, delays their differentiation and promotes hemoglobin synthesis, thereby improving ineffective erythropoiesis and reducing apoptosis. SB-590885 exerts a synergistic effect with TGF-β inhibitors and glucocorticoids, significantly promoting the formation of erythroid colonies in cells from patients with Diamond-Blackfan anemia (DBA). SB-590885 is mainly used in relevant studies on DBA, cisplatin-induced myelosuppression-related anemia, and pan-cancers such as melanoma and colorectal cancer .
Cat. No.: HY-P76136
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: AHSP; Alpha-Hemoglobin-Stabilizing Protein; Prev. ERAF; erythroid-Associated Factor; EDRF; erythroid differentiation Associated Factor; erythroid differentiation-Related Factor; erythroid Associated Factor; Alpha Hemoglobin Stabilizing Protein; Alpha Hemo
Species:
Human
Source:
E. coli
Cat. No.: HY-P992451
Synonyms: KY1066
Research Areas:
Cat. No.: HY-10966G
CAS No.: 405554-55-4
Cat. No.: HY-P704360
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: INHBA; Follicle-Stimulating Hormone-Releasing Protein; Inhibin Subunit Beta A; erythroid differentiation Factor; Inhibin Beta A Chain; Inhibin Beta A Subunit; Activin Beta-A Chain; FSH-Releasing Protein; Inhibin, Beta A (Activin A, Activin AB Alpha Polype
Species:
Mouse
Human
Rat
Source:
CHO
Cat. No.: HY-P70311G
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: INHBA; Follicle-Stimulating Hormone-Releasing Protein; Inhibin Subunit Beta A; erythroid differentiation Factor; Inhibin Beta A Chain; Inhibin Beta A Subunit; Activin Beta-A Chain; FSH-Releasing Protein; Inhibin, Beta A (Activin A, Activin AB Alpha Polype
Species:
Mouse
Human
Rat
Source:
HEK293
Cat. No.: HY-P703994Y
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: INHBA; Follicle-Stimulating Hormone-Releasing Protein; Inhibin Subunit Beta A; erythroid differentiation Factor; Inhibin Beta A Chain; Inhibin Beta A Subunit; Activin Beta-A Chain; FSH-Releasing Protein; Inhibin, Beta A (Activin A, Activin AB Alpha Polype
Species:
Human
Source:
HEK293
Cat. No.: HY-P70311B
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: INHBA; Follicle-Stimulating Hormone-Releasing Protein; Inhibin Subunit Beta A; erythroid differentiation Factor; Inhibin Beta A Chain; Inhibin Beta A Subunit; Activin Beta-A Chain; FSH-Releasing Protein; Inhibin, Beta A (Activin A, Activin AB Alpha Polype
Species:
Rat
Mouse
Human
Source:
E. coli
Cat. No.: HY-P70311A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: INHBA; Follicle-Stimulating Hormone-Releasing Protein; Inhibin Subunit Beta A; erythroid differentiation Factor; Inhibin Beta A Chain; Inhibin Beta A Subunit; Activin Beta-A Chain; FSH-Releasing Protein; Inhibin, Beta A (Activin A, Activin AB Alpha Polype
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
