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29 Results for "

estrogen-dependent

" in MedChemExpress (MCE) Product Catalog:

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Fadrozole hydrochloride hemihydrate

3 Cited Publications

Cat. No.: HY-14247B

CAS No.: 176702-70-8

Synonyms: CGS 16949A hemihydrate; (Rac)-FAD286 hydrochloride hemihydrate

Target:

Cytochrome P450

Research Areas:

Endocrinology Cancer

Fadrozole hydrochloride hemihydrate is an orally active, potent, selective and nonsteroidal aromatase inhibitor, with an IC₅₀ of 6.4 nM. Fadrozole hydrochloride hemihydrate inhibits the production of estrogen and progesterone, with IC₅₀ values of 0.03 and 120 μM. Fadrozole hydrochloride hemihydrate shows prevention of spontaneous tumours. Fadrozole hydrochloride hemihydrate can be used for the research of estrogen-dependent disease and cancer .

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Monoethyl phthalate

Cat. No.: HY-133668

CAS No.: 2306-33-4

Purity: 96.78%

Category:

Other disease Ketones, Aldehydes, Acids Disease markers Endogenous metabolite

Target:

Drug Metabolite Cytochrome P450 PPAR

Monoethyl phthalate is an orally active PDX-1 activator and the major hydrolytic metabolite of Diethyl phthalate (HY-Y0284) in vivo, with reproductive toxicity. Monoethyl phthalate targets aromatase (aromatase/CYP19A1) and PPAR to induce cell proliferation. The plasma protein binding rate of Monoethyl phthalate in rats and humans is lower than that of Diethyl phthalate. It exhibits significant enterohepatic circulation in rats and mainly accumulates in liver tissues. Monoethyl phthalate shows no estrogenic activity in estrogen-dependent human breast cancer cells. Monoethyl phthalate can be used in studies of reproductive toxicity and related environmental endocrine disruption mechanisms .

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