282

Tamoxifen Citrate

282 Publications Verification

Cat. No.: HY-13757

CAS No.: 54965-24-1

Purity: 99.93%

Synonyms: ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate

Target:

Estrogen Receptor/ERR HSP Autophagy Apoptosis

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice .

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282

Tamoxifen

282 Publications Verification

Cat. No.: HY-13757A

CAS No.: 10540-29-1

Purity: 99.78%

Synonyms: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen

Target:

Estrogen Receptor/ERR HSP Autophagy Apoptosis

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757) .

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149

Fulvestrant

149 Cited Publications

Cat. No.: HY-13636

CAS No.: 129453-61-8

Purity: 99.92%

Synonyms: ICI 182780; ZD 9238; ZM 182780

Target:

Estrogen Receptor/ERR Autophagy Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC₅₀ of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC₅₀ of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy .

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102

Cholesterol (from animal)

102 Cited Publications

Cat. No.: HY-N0322

CAS No.: 57-88-5

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Estrogen Receptor/ERR Bacterial Liposome

Cholesterol (from animal) is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol (from animal) plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol (from animal) is also an endogenous estrogen-related receptor α (ERRα) agonist .

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102

Cholesterol (Water Soluble)

102 Cited Publications

Cat. No.: HY-N0322A

Category:

Lipids Endogenous metabolite

Target:

Liposome

Cholesterol Water Soluble is a major sterol in mammals, constituting 20-25% of the structural composition of the plasma membrane. The plasma membrane is highly permeable to water but relatively impermeable to ions and protons. Cholesterol Water Soluble plays an important role in determining the fluidity and permeability characteristics of membranes and the function of transporters and signaling proteins. Cholesterol Water Soluble is also an endogenous estrogen-related receptor alpha (ERRα) agonist. Cholesterol Water Soluble can be used to study the effects of cholesterol on potassium currents in inner hair cells .
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)

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88

Kaempferol

88 Cited Publications

Cat. No.: HY-14590

CAS No.: 520-18-3

Purity: 99.92%

Synonyms: Kempferol; Robigenin

Category:

Flavonols Anti-aging Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Sunscreen Phenols Polyphenols Cosmetic Research Disease Research Fields Cancer

Target:

Estrogen Receptor/ERR Autophagy Mitophagy Apoptosis HIV Parasite Endogenous Metabolite

Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer .

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64

DHEA

64 Cited Publications

Cat. No.: HY-14650

CAS No.: 53-43-0

Purity: 99.93%

Synonyms: Prasterone; Dehydroisoandrosterone; Dehydroepiandrosterone

Category:

Human Gut Microbiota Metabolites Endogenous metabolite Disease Research Fields Cancer Steroids

Target:

Environmental Pollutants Endogenous Metabolite Androgen Receptor

DHEA (Prasterone) is one of the most abundant steroid hormones. DHEA (Prasterone) mediates its action via multiple signaling pathways involving specific membrane receptors and via transformation into androgen and estrogen derivatives (e.g., androgens, estrogens, 7α and 7β DHEA, and 7α and 7β epiandrosterone derivatives) acting through their specific receptors.

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62

4-Hydroxytamoxifen

62 Cited Publications

Cat. No.: HY-16950

CAS No.: 68047-06-3

Synonyms: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; (Z)-Afimoxifene

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen (HY-13757A) in vivo and can be used to induce gene knockout in transgenic mice expressing CreER .

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45

G15

45 Cited Publications

Cat. No.: HY-103449

CAS No.: 1161002-05-6

Purity: ≥99.0%

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a K_i of 20 nM .

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34

PHTPP

34 Cited Publications

Cat. No.: HY-103456

CAS No.: 805239-56-9

Purity: 99.70%

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

PHTPP is a selective estrogen receptor β (ERβ) antagonist with 36-fold selectivity over ERα .

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29

AZD9496

29 Cited Publications

Cat. No.: HY-12870

CAS No.: 1639042-08-2

Purity: 99.28%

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

AZD9496 is an effective, selective estrogen receptor (ERα) antagonist with an IC₅₀ of 0.28 nM. AZD9496 is an orally active, selective estrogen receptor degrader (SERD).

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29

AZD9496 maleate

29 Cited Publications

Cat. No.: HY-12870A

CAS No.: 1639042-28-6

Purity: 99.35%

Target:

Estrogen Receptor/ERR

Research Areas:

Cancer

AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC₅₀ of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD).

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