9

9 Publications Verification

Purity: 99%

Synonyms: Fura-2 Acetoxymethyl ester

Fura-2 AM is a membrane permeable, intracellular, UV light-excitable and ratiometric fluorescent Ca ²⁺ (calcium ion) indicator. Fura-2 AM crosses cell membranes and is converted to Fura-2 (HY-D0110A) via cellular esterases. Fura-2 AM can be used to detect calcium in cells.

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7

Xanomeline

7 Cited Publications

Cat. No.: HY-105182

CAS No.: 131986-45-3

Purity: 99.52%

Synonyms: LY-246708

Target:

mAChR

Research Areas:

Neurological Disease

Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia .

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6

Xanomeline tartrate

6 Cited Publications

Cat. No.: HY-105182A

CAS No.: 152854-19-8

Purity: 99.93%

Synonyms: LY 246708 tartrate

Target:

mAChR

Research Areas:

Neurological Disease

Xanomeline (LY 246708) is the potent agonist of muscarinic M1/M4 receptor with antipsychotic-like activity. Xanomeline (LY 246708) increases neuronal excitability. Xanomeline (LY 246708) can be used for the research of schizophrenia .

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4

KT5720

4 Cited Publications

Cat. No.: HY-N6789

CAS No.: 108068-98-0

Target:

PKA

Research Areas:

Neurological Disease Cancer

KT5720 is a potent, cell-permeable, specific, reversible and ATP-competitive PKA inhibitor (IC₅₀=3.3 μM). KT5720 is effective in reversing MDR1-mediated multidrug resistance. KT5720 also reduces the excitability of dorsal root ganglion (DRG) neurons by attenuating Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity and reducing intracellular Ca2 ⁺ concentrations. KT5720 can be used in the study of haematological malignancies as well as HCN and DRG neuron-related diseases .

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3

Poneratoxin acetate

3 Cited Publications

Cat. No.: HY-P10234A

Target:

Sodium Channel

Research Areas:

Neurological Disease

Poneratoxin acetate is the acetate salt form of Poneratoxin (HY-P10234). Poneratoxin acetate is the modulator for voltage-gated sodium channel (NaV, EC₅₀ for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals .

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2

Dihydrokainic acid

2 Cited Publications

Cat. No.: HY-100784

CAS No.: 52497-36-6

Purity: ≥99.0%

Target:

EAAT

Research Areas:

Neurological Disease

Dihydrokainic acid is a glutamate transporters (especially GLT1) inhibitor. Dihydrokainic acid targets GLT1 with high affinity, effectively inhibiting its transport function. Dihydrokainic acid exerts its effect by inhibiting the uptake of glutamate, leading to an increase in extracellular glutamate concentration, thereby affecting neuronal excitability and neurotransmission. Dihydrokainic acid is mainly applied in the field of neuroscience for research on glutamate-related neural functions, epilepsy, learning, and memory .

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1

Merocyanin 540

1 Cited Publications

Cat. No.: HY-D0127

CAS No.: 62796-23-0

Merocyanin 540 is a fluorescent membrane probe that selectively stains the membranes of a wide variety of electrically excitable cells, but not those of nonexcitable cells (Ex/Em: 540/580 nm) .

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