74

Dapagliflozin

74 Publications Verification

Cat. No.: HY-10450

CAS No.: 461432-26-8

Purity: 99.97%

Synonyms: BMS-512148

Target:

SGLT

Research Areas:

Metabolic Disease Cancer

Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .

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74

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

74 Publications Verification

Cat. No.: HY-10450A

CAS No.: 960404-48-2

Purity: 99.97%

Synonyms: BMS-512148 (2S)-1,2-propanediol, hydrate

Target:

SGLT

Research Areas:

Metabolic Disease Cancer

Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury .

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21

Cholic acid

21 Cited Publications

Cat. No.: HY-N0324

CAS No.: 81-25-4

Category:

Human Gut Microbiota Metabolites Microorganisms Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite

Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

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21

Cholic acid sodium

21 Cited Publications

Cat. No.: HY-N0324A

CAS No.: 361-09-1

Synonyms: Sodium cholate

Category:

Metabolic Disease Endogenous metabolite Disease Research Fields Steroids

Target:

Endogenous Metabolite

Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active .

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14

Enalapril

14 Cited Publications

Cat. No.: HY-B0331

CAS No.: 75847-73-3

Synonyms: MK-421

Target:

Angiotensin-converting Enzyme (ACE) Apoptosis Reactive Oxygen Species (ROS)

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease

Enalapril (MK-421) is an orally active angiotensin-converting enzyme inhibitor. Enalapril blocks the conversion of angiotensin I to angiotensin II, regulates the renin-angiotensin system, reduces preload and afterload, and decreases plasma angiotensin II levels. Enalapril inhibits apoptosis, reduces nitric oxide metabolite levels, stabilizes endothelial cells, enhances endothelial antioxidant defense, scavenges reactive oxygen species (ROS), and alleviates neuronal damage. Enalapril attenuates glutathione depletion, protein/lipid oxidation, tissue damage, and type III collagen immunolabeling in organs of diabetic rats. Enalapril reduces systolic blood pressure and urinary albumin excretion, and delays the progression of diabetic cardiac/renal injury. Enalapril is used in research related to asymptomatic left ventricular dysfunction, congestive heart failure, Alzheimer's disease, diabetes mellitus, acute myocardial infarction, atrial fibrillation, hypertension, cerebral ischemia, chronic heart failure, and single-ventricle physiology .

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14

Enalapril maleate

14 Cited Publications

Cat. No.: HY-B0331A

CAS No.: 76095-16-4

Synonyms: MK-421 maleate

Target:

Angiotensin-converting Enzyme (ACE) Apoptosis Reactive Oxygen Species (ROS)

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease

Enalapril maleate (MK-421 maleate) is an orally active angiotensin-converting enzyme inhibitor. Enalapril maleate blocks the conversion of angiotensin I to angiotensin II, regulates the renin-angiotensin system, reduces preload and afterload, and decreases plasma angiotensin II levels. Enalapril maleate inhibits apoptosis, reduces nitric oxide metabolite levels, stabilizes endothelial cells, enhances endothelial antioxidant defense, scavenges reactive oxygen species (ROS), and alleviates neuronal damage. Enalapril maleate attenuates glutathione depletion, protein/lipid oxidation, tissue damage, and type III collagen immunolabeling in organs of diabetic rats. Enalapril maleate reduces systolic blood pressure and urinary albumin excretion, and delays the progression of diabetic cardiac/renal injury. Enalapril maleate is used in research related to asymptomatic left ventricular dysfunction, congestive heart failure, Alzheimer's disease, diabetes mellitus, acute myocardial infarction, atrial fibrillation, hypertension, cerebral ischemia, chronic heart failure, and single-ventricle physiology .

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6

Cholic acid-d4

6 Cited Publications

Cat. No.: HY-N0324S

CAS No.: 116380-66-6

Cholic acid-d₄ is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

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6

Choline chloride

6 Cited Publications

Cat. No.: HY-B1337

CAS No.: 67-48-1

Category:

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

Histamine Receptor

Choline chloride is an orally active methylxanthine derivative. Choline chloride exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline chloride relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. Choline chloride modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline chloride is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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6

Choline theophyllinate

6 Cited Publications

Cat. No.: HY-B1718

CAS No.: 4499-40-5

Synonyms: Oxtriphylline

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Histamine Receptor

Choline theophyllinate (Oxtriphylline) is an orally active methylxanthine derivative. Choline theophyllinate exhibits weak antihistaminic and anticholinergic activities and potentiates the effects of histamine and acetylcholine. Choline theophyllinate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates locomotor activity in the central nervous system, and induces transient hypotension following a pressor phase. It modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline theophyllinate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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6

Choline (bitartrate)

6 Cited Publications

Cat. No.: HY-101036

CAS No.: 87-67-2

Purity: ≥98.0%

Category:

Animals Ketones, Aldehydes, Acids

Target:

Histamine Receptor

Choline bitartrate (Oxtriphylline) is an orally active methylxanthine-derived choline salt of theophylline. Choline bitartrate exhibits weak antihistaminic and anticholinergic activities and can enhance the effects of histamine and acetylcholine. Choline bitartrate relaxes bronchial smooth muscle, dilates coronary and peripheral blood vessels, increases urine output and electrolyte excretion, stimulates central nervous system motor activity, and induces transient hypotension following a pressor phase. Choline bitartrate modulates sleep architecture by increasing wakefulness time and reducing slow-wave sleep, without altering the frequency or severity of nocturnal hypoxemia, apnea, or hypopnea events. Choline bitartrate is used in studies of bronchospasm, nocturnal asthma, and chronic asthma .

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