489 Results for "

experimental

" in MedChemExpress (MCE) Product Catalog:
Products (489)

489 Results for "experimental" in MCE Product Catalog:

415
Dexamethasone
Dexamethasone
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415 Publications Verification
Cat. No.: HY-14648
CAS No.: 50-02-2
Purity:  99.86%
Synonyms: Hexadecadrol; Prednisolone F
Target:  

Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic ADC Payloads

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist, apoptosis inducer, and common disease inducer in experimental animals, constructing models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has potential for use in COVID-19 research .
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415
Dexamethasone (Water Soluble)
Dexamethasone (Water Soluble)
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415 Publications Verification
Cat. No.: HY-14648C
CAS No.: 50-02-2
Purity:  ≥98.0%
Synonyms: Dexamethasone cyclodextrin complex
Target:  

Exosomes Glucocorticoid Receptor SARS-CoV Autophagy Complement System Mitophagy Bacterial Antibiotic

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone (HY-14648). Dexamethasone is a glucocorticoid receptor agonist, apoptosis inducer, and a common disease inducer in experimental animals. It can be used to construct models of muscle atrophy, hypertension, and depression. Dexamethasone can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes. Dexamethasone also has the potential to be used in COVID-19 research .(Sale size is the weight of dexamethasone)
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162
Streptozotocin
Streptozotocin
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162 Cited Publications
Cat. No.: HY-13753
CAS No.: 18883-66-4
Purity:  99.20%
Synonyms: Streptozocin; NSC-85998; U 9889
Category:  

Microorganisms Antibiotics Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer

Target:  

DNA/RNA Synthesis DNA Alkylator/Crosslinker Autophagy Bacterial Antibiotic Apoptosis

Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells .
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92
DMOG
DMOG
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92 Cited Publications
Cat. No.: HY-15893
CAS No.: 89464-63-1
Purity:  99.69%
Synonyms: Dimethyloxallyl Glycine
Target:  

HIF/HIF Prolyl-Hydroxylase Autophagy

Research Areas:  

Cancer

DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo . DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal . DMOG induces cell autophagy .
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61
GSK484
GSK484
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61 Cited Publications
Cat. No.: HY-123606
CAS No.: 1652629-23-6
Target:  

Protein Arginine Deiminase MHC

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

GSK484 is a PAD4 inhibitor that effectively inhibits protein citrullination and the formation of neutrophil extracellular traps (NETs) by blocking the catalytic activity of PAD4. GSK484 suppresses the production of histone H3, MHC-I expression, CD8 + T cell activation, proliferation and inflammatory cytokine release. GSK484 reduces inflammation and bone destruction in collagen-induced rheumatoid arthritis, alleviates pain and mast cell activation in sickle cell disease, and improves myocardial ischemia-reperfusion injury and experimental colitis. In addition, GSK484 restores intestinal microbial homeostasis by reversing ferroptosis-induced dysbiosis. GSK484 can be used to study the disease mechanisms of rheumatoid arthritis, sickle cell disease, thrombosis, myocardial injury, colitis and other conditions .
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28
SiRNA Negative Control
SiRNA Negative Control
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28 Cited Publications
Cat. No.: HY-150150
Purity:  96.40%
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Inflammation/Immunology

SiRNA Negative Control is a siRNA of 21 nucleotides, and can be used as a negative control. SiRNA Negative Control has no homology to most known gene sequence. SiRNA Negative Control can be used in human, mouse and rat cells in vitro. SiRNA Negative Control can be used as experimental control benchmark, verification of experimental reliability and standardization reference. SiRNA Negative Control is a common negative control used in most research articles.
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27
L-Arginine
L-Arginine
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27 Cited Publications
Cat. No.: HY-N0455
CAS No.: 74-79-3
Category:  

Cardiovascular Disease Amino acids Endogenous metabolite Disease Research Fields Cancer

Target:  

NO Synthase Endogenous Metabolite

L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .
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27
L-Arginine hydrochloride
L-Arginine hydrochloride
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27 Cited Publications
Cat. No.: HY-N0455A
CAS No.: 1119-34-2
Synonyms: (S)-(+)-Arginine hydrochloride
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

NO Synthase Endogenous Metabolite

L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .
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27
ONX-0914
ONX-0914
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27 Cited Publications
Cat. No.: HY-13207
CAS No.: 960374-59-8
Purity:  99.72%
Synonyms: PR-957
Target:  

Proteasome Bacterial HIV

Research Areas:  

Infection Inflammation/Immunology

ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .
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27
ONX-0914 TFA
ONX-0914 TFA
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27 Cited Publications
Cat. No.: HY-13207A
Purity:  98.01%
Synonyms: PR-957 TFA
Target:  

Proteasome Bacterial HIV

Research Areas:  

Infection Inflammation/Immunology

ONX-0914 (PR-957) TFA is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1 .
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26
Selonsertib
Selonsertib
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26 Cited Publications
Cat. No.: HY-18938
CAS No.: 1448428-04-3
Synonyms: GS-4997
Target:  

MAP3K Apoptosis

Research Areas:  

Cancer

Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis.
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25
Complete Freund's adjuvant (CFA)
Complete Freund's adjuvant (CFA)
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25 Cited Publications
Cat. No.: HY-153808
CAS No.: 9007-81-2
Target:  

Toll-like Receptor (TLR)

Research Areas:  

Inflammation/Immunology

Complete Freund's adjuvant (CFA) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund to enhance an animal's immune response to an antigen. Complete Freund's adjuvant (CFA) is also an inducer of the Th1 immune response and a ligand of TLRs. Complete Freund's adjuvant (CFA) contains heat-killed inactive tuberculosis bacilli and consists of a paraffin oil-in-water emulsion. Complete Freund's adjuvant (CFA) stimulates a strong and durable immune response and can be used to induce persistent inflammatory pain models in mice, experimental autoimmune myocarditis (EAM) models, and more. Incomplete Freund's adjuvant (IFA) (HY-153808A) is another type of Freund's Adjuvant that stimulates a weaker immune response .
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19
Valspodar
Valspodar
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19 Cited Publications
Cat. No.: HY-17384
CAS No.: 121584-18-7
Synonyms: PSC 833
Target:  

P-glycoprotein

Research Areas:  

Cancer

Valspodar (PSC 833) is a selective P-glycoprotein inhibitor that has been used as an experimental cancer treatment and chemosensitizer.
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18
Polydatin
Polydatin
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18 Cited Publications
Cat. No.: HY-N0120A
CAS No.: 27208-80-6
Synonyms: Piceid
Category:  

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