50 Results for "

fat accumulation

" in MedChemExpress (MCE) Product Catalog:
Products (50)

50 Results for "fat accumulation" in MCE Product Catalog:

6
Tauro-β-muricholic acid
Tauro-β-muricholic acid
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6 Publications Verification
Cat. No.: HY-N9933
CAS No.: 25696-60-0
Synonyms: TβMCA
Category:  

Human Gut Microbiota Metabolites Animals Endogenous metabolite Steroids

Target:  

FXR Apoptosis

Tauro-β-muricholic acid (TβMCA) is an orally active trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC50=40 μM). Tauro-β-muricholic acid inhibits bile acid-induced hepatocyte apoptosis by maintaining mitochondrial membrane potential, while simultaneously inhibiting intestinal FXR signaling, affecting bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity. Accumulation of tauro-β-muricholic acid disrupts metabolic homeostasis, promoting cancer stem cell proliferation and tumor progression. The mechanisms of tauro-β-muricholic acid involve two aspects: first, inhibiting the translocation of the pro-apoptotic protein Bax to mitochondria and maintaining mitochondrial membrane potential (MMP); and second, blocking the FXR signaling pathway to regulate bile acid metabolism, reduce serum ceramide production, and downregulate the hepatic SREBP1C/CIDEA pathway. Tauro-β-muricholic acid possesses anti-hepatocyte apoptosis, bile acid homeostasis regulation, and liver fat accumulation reduction properties, and also functions as a biomarker, making it useful in the study of diseases such as bile acid metabolism disorders, non-alcoholic fatty liver disease, colorectal cancer, and liver fibrosis .
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3
Malabaricone C
Malabaricone C
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3 Cited Publications
Cat. No.: HY-N8518
CAS No.: 63335-25-1
Category:  

Metabolic Disease Phenols Polyphenols Plants 500 - Internal Server Error | MedChemExpress

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