25 Results for "

female rats

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "female rats" in MCE Product Catalog:

3
Menaquinone-7
Menaquinone-7
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3 Cited Publications
Cat. No.: HY-112499
CAS No.: 2124-57-4
Purity:  ≥98.0%
Synonyms: Vitamin K2-7; Vitamin K2(35); Vitamin MK-7
Target:  

TGF-beta/Smad

Research Areas:  

Cardiovascular Disease

Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS) .
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5-Methoxyindole-3-acetic acid
5-Methoxyindole-3-acetic acid
0 Images
1 Cited Publications
Cat. No.: HY-W007566
CAS No.: 3471-31-6
Category:  

Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

5-Methoxyindole-3-acetic acid is a metabolite of Melatonin (HY-B0075). 5-Methoxyindole-3-acetic acid significantly prolongs the estrous cycle, increases uterine weight, and induces ovarian follicular cysts in female rats, while also regulating the levels of related hormones .
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β-Estradiol 17-acetate
β-Estradiol 17-acetate
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1 Cited Publications
Cat. No.: HY-B0708
CAS No.: 1743-60-8
Synonyms: 1,3,5(10)-Estratriene-3,17β-diol 17-acetate
Category:  

Monophenols Animals Phenols Disease Research Fields Endocrinology Steroids

Target:  

Estrogen Receptor/ERR

β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) is a long-acting endogenous estrogen precursor and also a cell viability and proliferation enhancer. β-Estradiol 17-acetate promotes the adhesion and proliferation of freshly isolated and revived female-derived human brain microvascular endothelial cells, and reverses the decreased viability of revived male-derived human brain microvascular endothelial cells. β-Estradiol 17-acetate exerts the microvascular protective effect of estrogen, enabling non-tumor human brain microvascular endothelial cells to be cultured in vitro for 2 months after cryopreservation. β-Estradiol 17-acetate is biotransformed into β-estradiol via hydrolase action in the in vitro skin of humans, hairless dogs, rats and hairless mice .
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GKA50
GKA50
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Cat. No.: HY-15671
CAS No.: 851884-87-2
Purity:  99.57%
Target:  

Glucokinase

Research Areas:  

Metabolic Disease

GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans. GKA50 is a glucose-like activator of beta-cell metabolism in rodent and human islets and a Ca 2+-dependent modulator of insulin secretion. GKA50 shows significant glucose lowering in high fat fed female rats .
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Estradiol 17-(β-D-Glucuronide) sodium
Estradiol 17-(β-D-Glucuronide) sodium
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Cat. No.: HY-129987
CAS No.: 15087-02-2
Purity:  99.46%
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:  

Endogenous Metabolite P-glycoprotein

Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) sodium is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) sodium regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) sodium induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) sodium can be used in studies related to intrahepatic cholestasis .
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Estradiol 17-(β-D-Glucuronide)
Estradiol 17-(β-D-Glucuronide)
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Cat. No.: HY-W353102
CAS No.: 1806-98-0
Category:  

Monophenols Metabolic Disease Phenols Endogenous metabolite Disease Research Fields Endocrinology Steroids

Target:  

Endogenous Metabolite P-glycoprotein

Estradiol 17-(β-D-Glucuronide) is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) can be used in studies related to intrahepatic cholestasis .
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2-Hydroxysaclofen
2-Hydroxysaclofen
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Cat. No.: HY-100812
CAS No.: 117354-64-0
Purity:  ≥98.0%
Target:  

GABA Receptor

Research Areas:  

Neurological Disease Endocrinology

2-Hydroxysaclofen is a potent γ-amino-butyric-acid-B (GABAB) receptor antagonist. 2-Hydroxysaclofen can abolish nicotine-induced hypolocomotor effects and increases the antinociceptive effects. 2-Hydroxysaclofen can stimulate luteinizing hormone (LH) secretion in female rats .
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Humantenine
Humantenine
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Cat. No.: HY-N4031
CAS No.: 82375-29-9
Category:  

Alkaloids Other Diseases Loganiaceae Extract Plants 500 - Internal Server Error | MedChemExpress

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