78

78 Publications Verification

Synonyms: EMD 121974

Target:

Integrin TGF-β Receptor Apoptosis PD-1/PD-L1 STAT Akt mTOR

Cilengitide (EMD 121974) is an integrin (integrin) inhibitor with blood-brain barrier permeability, with IC₅₀ values against human targets as follows: 0.61 nM for αvβ3, 8.4 nM for αvβ5, 14.9 nM for α5β1, 5400 nM for αIIbβ3, 2050 nM for αvβ6, 2350 nM for αvβ8. Cilengitide inhibits the binding of integrins to vitronectin, fibronectin, fibrinogen and LAP (TGF-β), and serves as an internal standard for solid-phase integrin binding assays. Cilengitide inhibits tumor cell viability, induces apoptosis, reduces the phosphorylation levels of STAT3, AKT and mTOR, downregulates the expression of PD-L1, inhibits cell viability and angiogenesis, regulates anti-tumor immune responses and slows tumor growth. Cilengitide can be used in research related to glioblastoma, melanoma, advanced solid tumors and refractory brain tumors .

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78

Cilengitide TFA

78 Publications Verification

Cat. No.: HY-16143

CAS No.: 199807-35-7

Synonyms: EMD 121974 TFA

Target:

Integrin TGF-β Receptor Apoptosis PD-1/PD-L1 STAT Akt mTOR

Cilengitide TFA (EMD 121974 TFA) is an integrin (integrin) inhibitor with blood-brain barrier permeability, with IC₅₀ values against human targets as follows: 0.61 nM for αvβ3, 8.4 nM for αvβ5, 14.9 nM for α5β1, 5400 nM for αIIbβ3, 2050 nM for αvβ6, 2350 nM for αvβ8. Cilengitide TFA inhibits the binding of integrins to vitronectin, fibronectin, fibrinogen and LAP (TGF-β), and serves as an internal standard for solid-phase integrin binding assays. Cilengitide TFA inhibits tumor cell viability, induces apoptosis, reduces the phosphorylation levels of STAT3, AKT and mTOR, downregulates the expression of PD-L1, inhibits cell viability and angiogenesis, regulates anti-tumor immune responses and slows tumor growth. Cilengitide TFA can be used in research related to glioblastoma, melanoma, advanced solid tumors and refractory brain tumors .

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11

Bivalirudin

11 Cited Publications

Cat. No.: HY-P1929

CAS No.: 128270-60-0

Target:

Thrombin Interleukin Related RSV

Research Areas:

Infection Cardiovascular Disease Inflammation/Immunology

Bivalirudin, a hirudin analog and anticoagulant, is a direct thrombin inhibitor. Bivalirudin inhibits thrombin-mediated fibrinogen cleavage, coagulation factor activation, and platelet activation by reversibly binding to thrombin. In addition, Bivalirudin also has certain effects of anti-virus, anti-inflammation, and vascular endothelial barrier function protection. Bivalirudin can be used for the research of thrombotic diseases and others .

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11

Bivalirudin TFA

11 Cited Publications

Cat. No.: HY-15664

CAS No.: 1191386-55-6

Purity: 99.89%

Target:

Thrombin Interleukin Related RSV

Research Areas:

Infection Cardiovascular Disease Inflammation/Immunology

Bivalirudin TFA, a hirudin analog and anticoagulant, is a direct thrombin inhibitor. Bivalirudin TFA inhibits thrombin-mediated fibrinogen cleavage, coagulation factor activation, and platelet activation by reversibly binding to thrombin. In addition, Bivalirudin TFA also has certain effects of anti-virus, anti-inflammation, and vascular endothelial barrier function protection. Bivalirudin TFA can be used for the research of thrombotic diseases and others .

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9

Human α-Thrombin (Lyophilized)

9 Cited Publications

Cat. No.: HY-114164H

CAS No.: 9002-04-4

Synonyms: EC 3.4.21.5 (Lyophilized); Human Alpha Thrombin (Lyophilized)

Target:

Ser/Thr Protease Thrombin Protease Activated Receptor (PAR) Factor Xa

Research Areas:

Cardiovascular Disease

Human α-Thrombin (EC 3.4.21.5; Human Alpha Thrombin) (Lyophilized) is a terminal serine protease in the coagulation cascade, as well as a potent physiological platelet agonist and fibrin-generating enzyme in vivo. Human α-Thrombin catalyzes the conversion of fibrinogen to fibrin for blood clot formation, and activates platelet aggregation by cleaving the protease-activated receptors PAR1 (major) (K_d = 1 nM) and PAR4 (minor) on the platelet surface to expose tethered ligands. Human α-Thrombin also amplifies coagulation via positive feedback by activating coagulation factors V, VIII, XI (FV/FVIII/FXI), and switches to activate protein C to exert anticoagulant effects after binding to thrombomodulin .
This product is in a freeze-dried form.

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6

Tirofiban hydrochloride monohydrate

6 Cited Publications

Cat. No.: HY-17369

CAS No.: 150915-40-5

Synonyms: L700462 hydrochloride monohydrate; MK383 hydrochloride monohydrate

Target:

Integrin

Research Areas:

Cardiovascular Disease

Tirofiban (L700462) hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride monohydrate induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .

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6

Tirofiban

6 Cited Publications

Cat. No.: HY-17369B

CAS No.: 144494-65-5

Synonyms: L700462; MK383

Target:

Integrin

Research Areas:

Cardiovascular Disease

Tirofiban (L700462) is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area .

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6

Leukadherin-1

6 Cited Publications

Cat. No.: HY-15701

CAS No.: 344897-95-6

Purity: ≥98.0%

Target:

Integrin Complement System

Research Areas:

Inflammation/Immunology

Leukadherin-1, a specific agonist of the leukocyte surface integrin CD11b/CD18, increases CD11b/CD18-dependent cell adhesion to fibrinogen with an EC₅₀ of 4 μM. Leukadherin-1 enhances leukocyte adhesion to ligands (such as ICAM-1) and vascular endothelium and thus reduces leukocyte transendothelial migration and influx to the injury sites. Leukadherin-1 suppresses innate inflammatory signaling .

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3

GPRP acetate

3 Cited Publications

Cat. No.: HY-P0074A

CAS No.: 157009-81-9

Synonyms: Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate

Target:

Integrin

Research Areas:

Cardiovascular Disease

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa) .

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3

GPRP

3 Cited Publications

Cat. No.: HY-P0074

CAS No.: 67869-62-9

Synonyms: Gly-Pro-Arg-Pro; Pefa 6003

Target:

Thrombin

Research Areas:

Cardiovascular Disease

GPRP (Gly-Pro-Arg-Pro; Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction between fibrinogen and the platelet membrane glycoprotein Ⅱb/IIIa complex (glycoprotein IIb/IIIa receptor) . GPRP increases the level of free thrombin in activated platelet-rich plasma by reducing the adsorption of thrombin onto fibrin. GPRP inhibits platelet aggregation and prolongs the thrombin-initiated clotting time in plasma. GPRP is applicable for research related to thrombosis and thrombotic diseases .

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2

Fibrinogen (Bovine)

2 Cited Publications

Cat. No.: HY-125864

CAS No.: 9001-32-5

Fibrinogen (Bovine) is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

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2

Murine Fibrinogen

2 Cited Publications

Cat. No.: HY-125864B

CAS No.: 9001-32-5

Target:

MMP Cadherin

Research Areas:

Cardiovascular Disease Neurological Disease

Murine Fibrinogen is a native fibrinogen derived from mouse plasma. Murine Fibrinogen acts as a cerebrovascular permeability enhancer. Murine Fibrinogen activates matrix metalloproteinase-9 (MMP-9), downregulates the expression of vascular endothelial cadherin (VE-cadherin), and upregulates the expression of plasmalemmal vesicle-associated protein-1 (PV-1). Murine Fibrinogen increases macromolecular leakage from pial veins, thereby disrupting the microvascular integrity of cerebral blood vessels. Murine Fibrinogen can be used in studies related to cerebrovascular dysfunction .

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2

Porcine Fibrinogen

2 Cited Publications

Cat. No.: HY-125864C

CAS No.: 9001-32-5

Target:

Biochemical Assay Reagents

Research Areas:

Cardiovascular Disease

Porcine Fibrinogen is a coagulation protein, purified from porcine plasma with no plasminogen contained. Porcine Fibrinogen has excellent biocompatibility and does not induce aggregation of porcine platelets when in contact with porcine hepatocytes, aortic endothelial cells or hepatic sinusoidal endothelial cells. Porcine Fibrinogen is widely used in studies on the pathological mechanisms of cardiovascular diseases such as atherosclerosis and the development of related drugs .

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2

Rabbit Fibrinogen

2 Cited Publications

Cat. No.: HY-125864D

CAS No.: 9001-32-5

Target:

Interleukin Related NF-κB

Research Areas:

Cardiovascular Disease

Rabbit Fibrinogen is a native fibrinogen from rabbit plasma. Fibrinogen is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

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2

FGL2 Protein, Mouse (HEK293, His-Avi, Flag)

2 Cited Publications

Cat. No.: HY-P700990

Purity: ≥ 95%, as determined by Bis-Tris PAGE.

Synonyms: FGL2; fibrinogen-Like Protein 2; fibrinogen Like 2; T49; Fibroleukin; fibrinogen-Like 2; PT49

Species:

Mouse

Source:

HEK293

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2

ANGPTL4/Angiopoietin-related 4 Protein, Human (HEK293, His)

2 Cited Publications

Cat. No.: HY-P7507

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: ANGPTL4; Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Induced Angiopoietin-Related Protein; Angiopoietin Like 4; Hepatic Angiopoietin-Related Protein; HFARP; PPARG Angiopoietin Related Protein; PGAR; Fasting-Induced Adipose Factor; ARP4; Angiopoietin-Like Protein 4; Hepatic fibrinogen/Angiopoietin-Related Protein; Angiopoietin-Like 4; Angiopoietin-Related Protein 4; UNQ171; Pp1158; TGQTL; FIAF; HARP; NL2

Species:

Human

Source:

HEK293

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1

Fibrinogen-Binding Peptide

1 Cited Publications

Cat. No.: HY-P1741

CAS No.: 137235-80-4

Target:

Amino Acid Derivatives

Research Areas:

Cardiovascular Disease

Fibrinogen-Binding Peptide is a Fibrinogen-binding peptide. Fibrinogen-Binding Peptide inhibits platelet adhesion to vitronectin and fibrinogen. Fibrinogen-Binding Peptide inhibits platelet aggregation in ADP-stimulated platelet-rich plasma and in thrombin-stimulated washed platelets. Fibrinogen-Binding Peptide can be used for research on thrombosis .

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1

Fibrinogen-Binding Peptide TFA

1 Cited Publications

Cat. No.: HY-P1741A

Target:

Amino Acid Derivatives

Research Areas:

Cardiovascular Disease

Fibrinogen-Binding Peptide TFA is a Fibrinogen-binding peptide. Fibrinogen-Binding Peptide TFA inhibits platelet adhesion to vitronectin and fibrinogen. Fibrinogen-Binding Peptide TFA inhibits platelet aggregation in ADP-stimulated platelet-rich plasma and in thrombin-stimulated washed platelets. Fibrinogen-Binding Peptide TFA can be used for research on thrombosis .

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