596 Results for "

fibroblasts

" in MedChemExpress (MCE) Product Catalog:
Products (596)

596 Results for "fibroblasts" in MCE Product Catalog:

513
MK-2206
MK-2206
0 Images
513 Publications Verification
Cat. No.: HY-108232
CAS No.: 1032349-77-1
Purity:  99.72%
Target:  

Bcl-2 Family Apoptosis mTOR Akt GSK-3

Research Areas:  

Metabolic Disease Inflammation/Immunology Cancer

MK-2206 is an orally active pan-AKT inhibitor, with IC50 values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 induces G1-phase cell cycle arrest, apoptosis, epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia .
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513
MK-2206 dihydrochloride
MK-2206 dihydrochloride
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513 Publications Verification
Cat. No.: HY-10358
CAS No.: 1032350-13-2
Purity:  99.94%
Synonyms: MK-2206 (2HCl)
Target:  

Bcl-2 Family Apoptosis mTOR Akt GSK-3

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

MK-2206 dihydrochloride (MK-2206 2HCl) is an orally active pan-AKT inhibitor, with IC50 values of 8 nM, 12 nM and 65 nM against AKT1, AKT2 and AKT3, respectively. MK-2206 dihydrochloride inhibits the Akt/mTOR signaling pathway and reduces the levels of downstream GSK3β and Mcl-1 via proteasomal degradation. MK-2206 dihydrochloride induces G1-phase cell cycle arrest, apoptosis, epithelial-mesenchymal transition, fibroblast activation and extracellular matrix deposition. MK-2206 dihydrochloride causes transient hyperglycemia and hyperinsulinemia in animals. MK-2206 dihydrochloride can be used in research related to solid tumors, renal fibrosis and hypercholesterolemia .
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266
Angiotensin II human
Angiotensin II human
0 Images
266 Cited Publications
Cat. No.: HY-13948
CAS No.: 4474-91-3
Purity:  99.98%
Synonyms: Angiotensin II; Ang II; DRVYIHPF
Category:  

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:  

Angiotensin Receptor Apoptosis

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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266
Angiotensin II human acetate
Angiotensin II human acetate
0 Images
266 Cited Publications
Cat. No.: HY-13948A
CAS No.: 68521-88-0
Purity:  99.62%
Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate
Target:  

Angiotensin Receptor Apoptosis

Research Areas:  

Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer

Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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266
Angiotensin II human TFA
Angiotensin II human TFA
0 Images
266 Cited Publications
Cat. No.: HY-13948B
CAS No.: 2761969-44-0
Purity:  98.84%
Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA
Target:  

Angiotensin Receptor Apoptosis

Research Areas:  

Cardiovascular Disease Metabolic Disease Cancer

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .
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116
SIS3
SIS3
0 Images
116 Cited Publications
Cat. No.: HY-13013
CAS No.: 521984-48-5
Purity:  99.62%
Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 .
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116
SIS3 free base
SIS3 free base
0 Images
116 Cited Publications
Cat. No.: HY-100444
CAS No.: 521985-36-4
Purity:  98.11%
Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2 .
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67
Ilomastat
Ilomastat
0 Images
67 Cited Publications
Cat. No.: HY-15768
CAS No.: 142880-36-2
Purity:  98.39%
Synonyms: GM6001; Galardin
Target:  

MMP

Research Areas:  

Cancer

Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).
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42
Talabostat mesylate
Talabostat mesylate
0 Images
42 Cited Publications
Cat. No.: HY-13233A
CAS No.: 150080-09-4
Purity:  98.35%
Synonyms: Val-boroPro mesylate; PT100 mesylate
Target:  

Dipeptidyl Peptidase

Research Areas:  

Inflammation/Immunology Cancer

Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor (IC50 < 4 nM; Ki = 0.18 nM) and the inhibitor of fibroblast activation protein (FAP) (IC50 = 560 nM), inhibits DPP8/9 (IC50 = 4/11 nM; Ki = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) (IC50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities .
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34
FAPI-4
FAPI-4
0 Images
34 Cited Publications
Cat. No.: HY-128643
CAS No.: 2374782-02-0
Purity:  98.29%
Target:  

FAP

Research Areas:  

Cancer

FAPI-4 is a potent fibroblast activation protein (FAP) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer, with good tumor-to-background contrast ratios .
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20
Ferulic acid
Ferulic acid
0 Images
20 Cited Publications
Cat. No.: HY-N0060
CAS No.: 1135-24-6
Synonyms: Coniferic acid
Category:  

Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Monophenols Sunscreen Simple Phenylpropanols Phenols Cosmetic Research Phenylpropanoids Disease Research Fields Cancer

Target:  

FGFR Endogenous Metabolite

Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.
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20
Ferulic acid sodium
Ferulic acid sodium
0 Images
20 Cited Publications
Cat. No.: HY-N0060A
CAS No.: 24276-84-4
Synonyms: Coniferic acid sodium
Category:  

Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Plants Other Families Extract Endogenous metabolite Disease Research Fields Cancer

Target:  

FGFR Endogenous Metabolite Reactive Oxygen Species (ROS)

Ferulic acid sodium is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.
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20
Asiaticoside
Asiaticoside
0 Images
20 Cited Publications
Cat. No.: HY-N0439
CAS No.: 16830-15-2
Category:  

Cardiovascular Disease Triterpenes Neurological Disease 500 - Internal Server Error | MedChemExpress

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