256 Results for "

flavonoid compound

" in MedChemExpress (MCE) Product Catalog:

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Isorhamnetin

23 Publications Verification

Cat. No.: HY-N0776

CAS No.: 480-19-3

Synonyms: 3'-Methylquercetin

Category:

Cardiovascular Disease Leguminosae/Fabaceae Extract Flavonols Glycyrrhiza uralensis Fisch. Extract Hippophaë rhamnoides Extract Endogenous metabolite Plant Flavonoids Elaeagnaceae Extract Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

MEK PI3K Endogenous Metabolite

Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.

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Oroxylin A

21 Cited Publications

Cat. No.: HY-N0560

CAS No.: 480-11-5

Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein

Category:

Plant Flavonoids Oroxylum indicum (Linn.) Bentham ex Kurz Extract Flavones Phenols Polyphenols Bignoniaceae Extract Disease Research Fields Cancer

Target:

HIF/HIF Prolyl-Hydroxylase Autophagy Virus Protease

Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis .

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Cynaroside

15 Cited Publications

Cat. No.: HY-N0540

CAS No.: 5373-11-5

Synonyms: Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside

Category:

Anthriscus sylvestris (L.) Hoffm. Extract Flavones Cirsium vulgare(Savi) Ten. Extract Compositae/Asteraceae Extract Umbelliferae/Apiaceae Extract Infection Plant Flavonoids Phenols Polyphenols Disease Research Fields

Target:

Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal

Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

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Scutellarein

14 Cited Publications

Cat. No.: HY-N0752

CAS No.: 529-53-3

Synonyms: 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone

Category:

Plant Flavonoids Flavones Phenols Polyphenols Scutellaria baicalensis Georgi Extract Disease Research Fields Cancer Labiatae Extract

Target:

Free Radical Scavengers Src Autophagy SARS-CoV

Scutellarein is a natural flavonoid compound with anti-inflammatory effects.

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Hematoxylin

12 Cited Publications

Cat. No.: HY-N0116

CAS No.: 517-28-2

Synonyms: Natural Black 1; Haematoxylin

Category:

Leguminosae/Fabaceae Extract Plant Caesalpinia sappan L. Extract Other Diseases Phenols Polyphenols Disease Research Fields

Target:

Amyloid-β

Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn.. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC₅₀ of 1.6 μM.

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Astilbin

10 Cited Publications

Cat. No.: HY-N0509

CAS No.: 29838-67-3

Category:

Flavanonols Plant Flavonoids Phenols Polyphenols Other Families Extract Disease Research Fields Cancer

Target:

Keap1-Nrf2 TNF Receptor NF-κB

Astilbin is a flavonoid compound and enhances NRF2 activation. Astilbin also suppresses TNF-α expression and NF-κB activation.

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Neohesperidin

9 Cited Publications

Cat. No.: HY-N0101

CAS No.: 13241-33-3

Synonyms: Hesperetin 7-O-neohesperidoside

Category:

Rutaceae Extract Other Families Extract Plant Flavonoids Flavonones Phenols Polyphenols Disease Research Fields Inflammation/Immunology Citrus Extract

Target:

β-catenin Free Radical Scavengers Wnt

Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the Wnt/β-catenin signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells .

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Licochalcone D

5 Cited Publications

Cat. No.: HY-N4187

CAS No.: 144506-15-0

Category:

Leguminosae/Fabaceae Extract Glycyrrhiza uralensis Fisch. Extract Metabolic Disease Plant Flavonoids Chalcones Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

NF-κB Apoptosis Reactive Oxygen Species (ROS)

Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties .

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Syringaldehyde

5 Cited Publications

Cat. No.: HY-N1390

CAS No.: 134-96-3

Category:

Plant Monophenols Ketones, Aldehydes, Acids Phenols Manihot esculenta Crantz Extract Disease Research Fields Inflammation/Immunology Euphorbiaceae Extract

Target:

COX

Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis . Syringaldehyde moderately inhibits COX-2 activity with an IC₅₀ of 3.5 μg/mL . Anti-hyperglycemic and anti-inflammatory activities .

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Licochalcone E

4 Cited Publications

Cat. No.: HY-N4182

CAS No.: 864232-34-8

Category:

Leguminosae/Fabaceae Extract Plant Flavonoids Chalcones Glycyrrhiza uralensis Fisch. Extract Disease Research Fields Inflammation/Immunology

Target:

Akt p38 MAPK Autophagy

Licochalcone E, a flavonoid compound isolated from Glycyrrhiza uralensis, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation .

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Hydroxygenkwanin

4 Cited Publications

Cat. No.: HY-N1438

CAS No.: 20243-59-8

Synonyms: 7-O-Methylluteolin

Category:

Thymelaeaceae Extract Plant Flavonoids Daphne genkwa Sieb. et Zucc. Extract Flavones Phenols Polyphenols Disease Research Fields Cancer

Target:

Others

Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, is one of the main components of Lilac Daphne. Hydroxygenkwanin has anti-oxidant ability, anti-glioma ability and anticancer effect .

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Glabrol

4 Cited Publications

Cat. No.: HY-N4193

CAS No.: 59870-65-4

Category:

Cardiovascular Disease Leguminosae/Fabaceae Extract Plant Flavonoids Glycyrrhiza uralensis Fisch. Extract Flavonones Phenols Polyphenols Disease Research Fields

Target:

Acyltransferase

Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

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Isoxanthohumol

4 Cited Publications

Cat. No.: HY-N2584A

CAS No.: 521-48-2

Category:

Infection Plant Flavonoids Anti-aging Moraceae Extract Flavonones Disease Research Fields Humulus lupulus L. Extract Cancer

Target:

HSV Apoptosis Reactive Oxygen Species (ROS) Autophagy CMV Fungal Integrin S100 Protein

Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases .

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4',5-Dihydroxyflavone

3 Cited Publications

Cat. No.: HY-N1881

CAS No.: 6665-67-4

Category:

Leguminosae/Fabaceae Extract Plant Flavonoids Flavones Glycine max (L.) merr Extract Other Diseases Phenols Polyphenols Disease Research Fields

Target:

Lipoxygenase Glycosidase

4',5-Dihydroxyflavone (Compound 2c; Compound B3) is a type of flavonoid compound. 4',5-Dihydroxyflavone can inhibit various oxidases and its IC₅₀ values for collagenase A (ColA) and α-glucosidase are less than 1 μM and 66 μM respectively; for soybean lipoxygenase-1 (LOX-1), its K_i value is 102.6 μM. 4',5-Dihydroxyflavone can be used in studies on anti-toxicity and anti-diabetes .

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Saponarin

3 Cited Publications

Cat. No.: HY-N5083

CAS No.: 20310-89-8

Category:

Dipsacaceae Extract Plant Flavonoids Flavones Dipsacus sativus (Linn.) Honck. Extract Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:

PERK NF-κB p38 MAPK AMPK Interleukin Related COX

Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1β and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders .

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6-Hydroxyflavone

3 Cited Publications

Cat. No.: HY-N7110

CAS No.: 6665-83-4

Category:

Plant Flavonoids Monophenols Flavones Phenols Scutellaria baicalensis Georgi Extract Disease Research Fields Inflammation/Immunology Labiatae Extract

Target:

Akt ERK JNK GABA Receptor

6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABA_A) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role .

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5-Hydroxyflavone

2 Cited Publications

Cat. No.: HY-22024

CAS No.: 491-78-1

Synonyms: 5-OH-Flavone

Category:

Plant Flavonoids Monophenols Flavones Phenols Other Families Extract Disease Research Fields Cancer

Target:

Cytochrome P450

5-Hydroxyflavone (5-OH-Flavone) is a flavonoid compound that undergoes oxidation-mediated conversion to 5,7-dihydroxyflavone and 5,6,7-trihydroxyflavone by human cytochrome P450 enzymes .

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Breviscapine

2 Cited Publications

Cat. No.: HY-107802

CAS No.: 116122-36-2

Purity: 95.59%

Synonyms: Breviscapinun

Category:

Plant Flavonoids Flavones Erigeron breviscapus (Vant.) Hand.-Mazz. Extract Compositae/Asteraceae Extract

Target:

NF-κB Interleukin Related TGF-beta/Smad Calcium Channel

Breviscapine (Breviscapinun) is a flavonoid compound with antioxidant, anti-inflammatory, anti-fibrotic, and neuroprotective activities. Breviscapine ameliorates cerebral ischemia/reperfusion injury and vascular dementia, and inhibits the formation of postoperative abdominal adhesions. The mechanism of action of Breviscapine involves the regulation of oxidative stress, inflammatory cytokines, signaling pathways such as TGF-β/Smad, and cellular calcium overload. Breviscapine is used for research on diseases including cardiovascular and cerebrovascular diseases .

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3,7,4'-Trihydroxyflavone

2 Cited Publications

Cat. No.: HY-111806

CAS No.: 2034-65-3

Purity: 99.44%

Synonyms: 5-Deoxykampferol; Resokaempferol

Category:

Simaroubaceae Extract Flavonols Rhus chinensis Mill. Extract Plant Brucea javanica (L.) Merr. Extract Flavonoids Anacardiaceae Extract Other Diseases Phenols Polyphenols Disease Research Fields

Target:

Reactive Oxygen Species (ROS) Leukotriene Receptor DNA/RNA Synthesis

3,7,4'-Trihydroxyflavone (5-Deoxykampferol) is a flavonoid compound that can be isolated from the stems of Rhus javanica var. roxburghiana. 3,7,4'-Trihydroxyflavone has the effect of cleaving DNA in the presence of copper ions. 3,7,4'-Trihydroxyflavone also has anti-inflammatory and antioxidant activities and can scavenge various reactive oxygen species (ROS) and reactive nitrogen species (RNS) .

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Ligustroflavone

2 Cited Publications

Cat. No.: HY-N0546

CAS No.: 260413-62-5

Synonyms: Nuezhenoside

Category:

Plant Flavonoids Flavones Ligustrum lucidum Ait. Extract Metabolic Disease Phenols Polyphenols Oleaceae Extract Disease Research Fields

Target:

CaSR RIP kinase Mixed Lineage Kinase TGF-beta/Smad

Ligustroflavone is an orally active flavonoid compound. Ligustroflavone can be extracted from Ligustrum lucidum. Ligustroflavone antagonizes the calcium-sensing receptor (CaSR), inhibits the RIPK1/RIPK3/MLKL pathway, and downregulates TGF-β/Smad signaling. Ligustroflavone regulates calcium metabolism, protects bone tissue, reduces cerebral ischemic injury, and inhibits liver fibrosis. Ligustroflavone can be used in the study of diabetic osteoporosis, ischemic stroke, and liver fibrosis .

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