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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
62 Results for "
frizzled
" in MedChemExpress (MCE) Product Catalog:
Products (62)
62 Results for "frizzled" in MCE Product Catalog:
4
4 Cited Publications
Target:
Research Areas:
NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 μM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction .
4
3
3 Cited Publications
FzM1.8 is a Wnt/β-catenin signaling pathway agonist and an allosteric agonist of Frizzled 4 (FZD4), with a pEC50 of 6.4 for FZD4 . FzM1.8 stabilizes a conformation with increased affinity for heterotrimeric G proteins, promoting Gβγ release and subsequent PI3K activation. FzM1.8 activates the AKT pathway downstream of FZD4. FzM1.8 does not affect FZD4 maturation or plasma membrane localization and does not induce FZD4 endocytosis. FzM1.8 upregulates the WNT-responsive genes C-myc and Cyclin D1, while leaving lgr5 expression unchanged. FzM1.8 can be used for colon cancer research .
3
3 Cited Publications
Cat. No.: HY-P77835
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: SFRP2; Secreted Apoptosis-Related Protein 1; Secreted frizzled Related Protein 2; SARP-1; SARP1; SFRP-2; FRP-2; Secreted Apoptosis Related Protein 1; Secreted frizzled-Related Protein 2; Testicular Tissue Protein Li 170; SDF-5; FRP2
Species:
Human
Source:
HEK293
2
2 Cited Publications
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=?6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade .
2
2 Cited Publications
F7H is a Frizzled receptor FZD7 antagonist (IC50: 1.25 μM). Frizzled receptors (FZDs) influence Wnt signaling, mediating embryonic development and tissue homeostasis. F7H is a potent ligand for the FZD7 transmembrane domain (TMD) .
2
2 Cited Publications
SRI 37892 is a small molecule compound inhibitor of Frizzled protein 7 (Fzd7) with inhibitory activity against cancer cell proliferation (IC50=2μM). SRI 37892 significantly blocks Wnt/Fzd7 signaling. SRI 3789 can be used in the research of developing cancer therapeutic agents .
2
2 Cited Publications
Cat. No.: HY-P74554
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SFRP1; SARP-2; Secreted frizzled Related Protein 1; SFRP-1; SARP2; FRP1; FRP-1; frizzled-Related Protein; FRP; SFRP1 Protein; Secreted frizzled-Related Protein 1; FrzA; Secreted Apoptosis-Related Protein 2
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P71709
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FRZB; FZRB; frizzled Related Protein; HFIZ; Secreted frizzled-Related Protein 3; Frezzled; FRZB1; SFRP-3; SFRP3; FrzB-1; FRE; Uncharacterized Protein FRZB; frizzled-Related Protein 1; frizzled Homolog-Related; FRZB-PEN; frizzled-Related Protein; FRZB-1; F
Species:
E.coli
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P74551
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SFRP4; frizzled Protein, Human Endometrium; Secreted frizzled Related Protein 4; SFRP-4; FrpHE; Secreted frizzled-Related Protein 4; Secreted frizzled-Related Protein 4; Secreted frizzled-Related Protein 4; FRPHE; FRZB-2; PYL; FRP-4
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P73413
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SFRP1; SARP-2; Secreted frizzled Related Protein 1; SFRP-1; SARP2; FRP1; FRP-1; frizzled-Related Protein; FRP; SFRP1 Protein; Secreted frizzled-Related Protein 1; FrzA; Secreted Apoptosis-Related Protein 2
Species:
Mouse
Source:
CHO
Cat. No.: HY-10860
CAS No.: 915763-27-8
Research Areas:
WAY-362692 is a secreted frizzled-related protein (sFRP-1) inhibitor (IC50 of 0.02 μM), targeting the netrin domain of sFRP-1. WAY-362692 can competitively inhibit the interaction between sFRP-1 and Wnt proteins, and activate the Wnt/β-catenin signaling pathway (EC50 = 0.03 μM). WAY-362692 can activate osteoblasts and promote bone remodeling. WAY-362692 can be used for the research of metabolic disease, such as osteoporosis .
Cat. No.: HY-P99582
CAS No.: 1644134-10-0
Synonyms: ONC-005, OTSA101
Target:
Research Areas:
Cat. No.: HY-182624
CAS No.: 873841-43-1
Target:
Research Areas:
FJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC50 1540 μM, NHERF1 PDZ2 IC50 160 μM, and Frizzled-7-Dishevelled PDZ complex Ki 10 μM. FJ9 binds ligand-binding pockets of NHERF1 PDZ domains to block cognate ligand interactions, disrupts Frizzled-7-Dishevelled interactions, and down-regulates canonical Wnt signaling. FJ9 induces apoptosis in cancer cells with intact β-catenin signaling. FJ9 can be used for the research of non-small cell lung cancer, melanoma .
Cat. No.: HY-P78730
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FZD7; Fz-7; frizzled Class Receptor 7; HFz7; FzE3; frizzled, Drosophila, Homolog Of, 7; frizzled-7; frizzled (Drosophila) Homolog 7; frizzled 7, Seven Transmembrane Spanning Receptor; frizzled Homolog 7 (Drosophila); frizzled Family Receptor 7; frizzled H
Species:
Human
Source:
HEK293
Cat. No.: HY-P79214
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FZD7; Fz-7; frizzled Class Receptor 7; HFz7; FzE3; frizzled, Drosophila, Homolog Of, 7; frizzled-7; frizzled (Drosophila) Homolog 7; frizzled 7, Seven Transmembrane Spanning Receptor; frizzled Homolog 7 (Drosophila); frizzled Family Receptor 7; frizzled Homolog 7
Species:
Human
Source:
CHO
Cat. No.: HY-P705549
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FZD7; Fz-7; frizzled Class Receptor 7; HFz7; FzE3; frizzled, Drosophila, Homolog Of, 7; frizzled-7; frizzled (Drosophila) Homolog 7; frizzled 7, Seven Transmembrane Spanning Receptor; frizzled Homolog 7 (Drosophila); frizzled Family Receptor 7; frizzled H
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
