18

Branaplam

18 Publications Verification

Cat. No.: HY-19620

CAS No.: 1562338-42-4

Synonyms: LMI070; NVS-SM1

Target:

DNA/RNA Synthesis Potassium Channel

Research Areas:

Cancer

Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .

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18

Branaplam hydrochloride

18 Publications Verification

Cat. No.: HY-19620A

CAS No.: 1562338-39-9

Synonyms: LMI070 hydrochloride; NVS-SM1 hydrochloride

Target:

DNA/RNA Synthesis Potassium Channel

Research Areas:

Cancer

Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .

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16

MicroRNA Inhibitor Negative Control

16 Cited Publications

Cat. No.: HY-RI04602

Target:

MicroRNA

Research Areas:

Others

MicroRNA Inhibitor Negative Control is a full-length nucleotide 2'-methoxy modified oligonucleotide, and can be used as a negative control. The sequence of MicroRNA Inhibitor Negative Control is derived from cel-mir-239b. It has minimal sequence identity with miRNAs in human, mouse, and rat.

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9

ML216

9 Cited Publications

Cat. No.: HY-12342

CAS No.: 1430213-30-1

Purity: 99.89%

Synonyms: CID-49852229

Target:

DNA/RNA Synthesis

Research Areas:

Cancer

ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC₅₀s of 2.98 μM and 0.97 μM for BLM ^full-length and BLM ^636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a K_i of 1.76 μM. Antitumor avtivity .

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8

GNE-6640

8 Cited Publications

Cat. No.: HY-112937

CAS No.: 2009273-67-8

Purity: 99.91%

Target:

Deubiquitinase

Research Areas:

Cancer

GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC₅₀ values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively .

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7

Nusinersen

7 Cited Publications

Cat. No.: HY-112980

CAS No.: 1258984-36-9

Purity: 97.79%

Target:

DNA/RNA Synthesis

Research Areas:

Neurological Disease

Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen improves spinal muscular atrophy .

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7

Nusinersen sodium

7 Cited Publications

Cat. No.: HY-112980A

Purity: 98.91%

Target:

DNA/RNA Synthesis

Research Areas:

Neurological Disease

Nusinersen sodium is an antisense oligonucleotide active molecule. Nusinersen sodium modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen sodium improves spinal muscular atrophy .

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6

AZD5153

6 Cited Publications

Cat. No.: HY-100653

CAS No.: 1869912-39-9

Purity: 99.20%

Target:

Epigenetic Reader Domain Apoptosis

Research Areas:

Cancer

AZD5153 is a bivalent, selective, and orally active BET/BRD4 bromodomain inhibitor with an IC₅₀ of value of 5 nM for full-length BRD4 (FL-BRD4). AZD5153 ligates two bromodomains in BRD4 simultaneously. AZD5153 can be used for the study of cancer, such as acute myeloid leukemia, multiple myeloma, and diffuse large B-cell lymphoma .

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