5 Results for "

fulminant

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "fulminant" in MCE Product Catalog:

4
D(+)-Galactosamine hydrochloride
D(+)-Galactosamine hydrochloride
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4 Cited Publications
Cat. No.: HY-42682
CAS No.: 1772-03-8
Synonyms: D-Galactosamine HCl
Category:  

Vitaceae Extract Plant Microorganism Disease Research Fields Inflammation/Immunology Vitis vinifera cv. Zalema Extract Saccharides Monosaccharides

Target:  

Drug Derivative

D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure .
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4
(±)-Naringenin
(±)-Naringenin
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4 Cited Publications
Cat. No.: HY-W011641
CAS No.: 67604-48-2
Category:  

Cardiovascular Disease Plant Flavonoids Flavonones Phenols Polyphenols Other Families Extract Disease Research Fields

Target:  

Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase

(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BKCa channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .
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D(+)-Galactosamine hydrochloride (Standard)
D(+)-Galactosamine hydrochloride (Standard)
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Cat. No.: HY-42682R
CAS No.: 1772-03-8
Synonyms: D-Galactosamine HCl (Standard)
Category:  

Vitaceae Extract Plant Microorganism Vitis vinifera cv. Zalema Extract Saccharides Monosaccharides

Target:  

Reference Standards

D(+)-Galactosamine (hydrochloride) (Standard) is the analytical standard of D(+)-Galactosamine (hydrochloride). This product is intended for research and analytical applications. D(+)-Galactosamine (D-Galactosamine) hydrochloride, which is an established experimental toxin, primarily causes liver injury by the generation of free radicals and depletion of UTP nucleotides. D(+)-Galactosamine hydrochloride intoxication also induces renal dysfunction thus, renal failure is often associated with the end-stage of the liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure .
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IDN-7314
IDN-7314
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Cat. No.: HY-111096
CAS No.: 254750-11-3
Target:  

Caspase

Research Areas:  

Cardiovascular Disease Metabolic Disease

IDN-7314 is a pan-Caspase inhibitor with an IC50 of 0.2-7 nM against all tested Caspases. IDN-7314 abrogates Jo2-induced caspase-3/7 activity. IDN-7314 reduces the procoagulant activity of tissue factor in hepatocytes. IDN-7314 is applicable to research related to chemically induced hepatitis, fulminant liver failure and apoptotic liver injury .
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CBI-3
CBI-3
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Cat. No.: HY-189721
Target:  

Bcl-2 Family Apoptosis

Research Areas:  

Neurological Disease Metabolic Disease

CBI-3 is a BAX inhibitor that covalently modifies BAX and blocks BAX-mediated apoptosis. CBI-3 protects primary rat dorsal root ganglion neurons and human induced pluripotent stem cell-derived motor neurons from apoptosis and spontaneous loss. CBI-3 reduces hepatocyte apoptosis and protects liver histology in an anti-Fas-induced acute liver injury mouse model. CBI-3 exhibits improved metabolic stability in mouse liver microsomes. CBI-3 can be used for research on Fas-induced fulminant hepatic failure and amyotrophic lateral sclerosis .
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