14 Results for "

gap junctional communication

" in MedChemExpress (MCE) Product Catalog:
Products (14)

14 Results for "gap junctional communication" in MCE Product Catalog:

3
Irsogladine
Irsogladine
0 Images
3 Cited Publications
Cat. No.: HY-B0327
CAS No.: 57381-26-7
Synonyms: Dicloguamine
Target:  

Phosphodiesterase (PDE) NF-κB AP-1 TRP Channel Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Irsogladine (Dicloguamine) is an orally active gastric mucosal protective agent. Irsogladine inhibits breast cancer recurrence and lung metastasis in nude mice . Irsogladine inhibits the transcriptional activities of NF-κB and AP-1, suppresses the activities of PDE and PDE4 to elevate intracellular cAMP levels, and activates TRPV1 and KATP channels. Irsogladine enhances iNOS expression, NO production, and the activation of cAMP-responsive elements. Irsogladine inhibits the development and progression of intestinal polyps in Apc-mutant mice. Irsogladine alleviates oxidative stress, increases gastric mucosal blood flow, and stimulates the production of endogenous prostaglandins. Irsogladine promotes insulin secretion in MIN6 cells. Irsogladine inhibits tumor angiogenesis, cancer cell proliferation, and the production of proinflammatory cytokines. Irsogladine exerts protective effects on astrocytes in ethanol/hydrochloric acid-induced gastric ulcers in mice. Irsogladine prevents colitis in IL-10 gene-deficient mice by reducing the production of IL-12 and IL-23. Irsogladine upregulates gap junction intercellular communication in pancreatic cancer cells via the PKA pathway. Irsogladine is applicable to research related to breast cancer, intestinal polyposis, gastric ulcer, spontaneous colitis, glioma, liver cancer, and pancreatic cancer [5][6] .
loading...
    loading...
View All Sizes
1
Rotigaptide
Rotigaptide
0 Images
1 Cited Publications
Cat. No.: HY-106225
CAS No.: 355151-12-1
Purity:  99.50%
Synonyms: ZP123
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically atrial fibrillation .
loading...
    loading...
View All Sizes
Antioxidant 1010
Antioxidant 1010
0 Images
Cat. No.: HY-W010653
CAS No.: 6683-19-8
Synonyms: lrganox 1010; AT1010
Target:  

Environmental Pollutants Biochemical Assay Reagents

Research Areas:  

Others

Antioxidant 1010 (lrganox 1010; AT1010) is a hindered phenolic antioxidant. Antioxidant 1010 does not inhibit intercellular gap-junctional communication. Antioxidant 1010 exhibits antioxidant efficacy in plastic, rubber and synthetic fiber .
loading...
    loading...
View All Sizes
Zymosan (ZM), 95%
Zymosan (ZM), 95%
0 Images
Cat. No.: HY-159069
CAS No.: 9010-72-4
Purity:  95.02%
Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and TNF-α mRNA expression, increases serum TNF-α levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation .
loading...
    loading...
View All Sizes
Calcein (tetraethyl ester)
Calcein (tetraethyl ester)
0 Images
Cat. No.: HY-D0830
CAS No.: 1170856-93-5
Synonyms: Fluorexon tetraethyl ester
Calcein tetraethyl ester is a tetraethylated derivative of calcein, with its core function serving as a live cell-specific fluorescent tracer. Calcein tetraethyl ester can diffuse between human periodontal ligament cells via gap junctions, thus enabling the evaluation of gap junction intercellular communication function, and its diffusion is enhanced under hydrogen peroxide induction. Calcein tetraethyl ester can be applied in the fields of cell biology and fluorescent labeling .
loading...
    loading...
View All Sizes
Pyrromethene 650
Pyrromethene 650
0 Images
Cat. No.: HY-W248583
CAS No.: 157410-23-6
Synonyms: PM650
Pyrromethene 650 (PM650) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.
loading...
    loading...
View All Sizes
Pyrromethene 605
Pyrromethene 605
0 Images
Cat. No.: HY-D1777
CAS No.: 137829-80-2
Synonyms: PM605
Pyrromethene 605 (PM605) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.
loading...
    loading...
View All Sizes
ACT1
ACT1
0 Images
Cat. No.: HY-P11197
CAS No.: 895547-36-1
Target:  

Gap Junction Protein

Research Areas:  

Cancer

ACT1 is a peptide that targets endogenous Cx43 by stabilizing its activity at gap junctions. ACT1 stabilizes gap junction intercellular communication in breast cancer cells. ACT1 enhances the activity of Tamoxifen (HY-13757A) and Lapatinib (HY-50898) in breast cancer. ACT1 can be used for breast cancer research .
loading...
    loading...
View All Sizes
Connexin mimetic peptide 40GAP27
Connexin mimetic peptide 40GAP27
0 Images
Cat. No.: HY-P5389
CAS No.: 403858-30-0
Target:  

Gap Junction Protein

Research Areas:  

Others

Connexin mimetic peptide 40GAP27 is a biological active peptide. (This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.)
loading...
    loading...
View All Sizes
Rotigaptide (Standard)
Rotigaptide (Standard)
0 Images
Cat. No.: HY-106225R
CAS No.: 355151-12-1
Synonyms: ZP123 (Standard)
Target:  

Reference Standards Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation .
loading...
    loading...
View All Sizes
Antioxidant 1010 (Standard)
Antioxidant 1010 (Standard)
0 Images
Cat. No.: HY-W010653R
CAS No.: 6683-19-8
Synonyms: lrganox 1010 (Standard); AT1010 (Standard)
Target:  

Reference Standards Biochemical Assay Reagents

Research Areas:  

Others

Antioxidant 1010 (Standard) is the analytical standard of Antioxidant 1010 (lrganox 1010; AT1010) (HY-W010653) . This product is intended for research and analytical applications. Antioxidant 1010 is a hindered phenolic antioxidant. Antioxidant 1010 does not inhibit intercellular gap-junctional communication. Antioxidant 1010 exhibits antioxidant efficacy in plastic, rubber and synthetic fiber ..
loading...
    loading...
View All Sizes
N-Methylarachidonamide
N-Methylarachidonamide
0 Images
Cat. No.: HY-134110
CAS No.: 156910-29-1
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
loading...
    loading...
View All Sizes
Arachidonoyl-N,N-dimethyl amide
Arachidonoyl-N,N-dimethyl amide
0 Images
Cat. No.: HY-134055
CAS No.: 45280-17-9
Synonyms: Arachidonic acid-N,N-dimethyl amide
Target:  

Cannabinoid Receptor

Research Areas:  

Metabolic Disease

Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N,N-dimethyl amide is an analog of anandamide that exhibits weak or no binding to the human central cannabinoid (CB1) receptor (Ki >1 μM). It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.
loading...
    loading...
View All Sizes
Tellimagrandin I
Tellimagrandin I
0 Images
Cat. No.: HY-N7764
CAS No.: 79786-08-6
Category:  

Phenols Polyphenols Plants Other Families Extract 500 - Internal Server Error | MedChemExpress

Oops!

Sorry, Something went wrong on our server.
Our team has been notified and is working to fix the issue.