74 Results for "

gemcitabine

" in MedChemExpress (MCE) Product Catalog:
Products (74)

74 Results for "gemcitabine" in MCE Product Catalog:

307
Gemcitabine
Gemcitabine
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307 Publications Verification
Cat. No.: HY-17026
CAS No.: 95058-81-4
Synonyms: LY 188011
Target:  

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy Apoptosis p38 MAPK

Research Areas:  

Infection Inflammation/Immunology Cancer

Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy. Gemcitabine induces apoptosis through the activation of p38 MAPK. Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer. Gemcitabine can be used for cancer research, such as pancreatic cancer, non-small cell lung cancer, and breast cancer .
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307
Gemcitabine hydrochloride
Gemcitabine hydrochloride
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307 Publications Verification
Cat. No.: HY-B0003
CAS No.: 122111-03-9
Synonyms: LY 188011 hydrochloride
Target:  

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Autophagy Apoptosis

Research Areas:  

Cancer

Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .
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5
Gemcitabine elaidate
Gemcitabine elaidate
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5 Cited Publications
Cat. No.: HY-13538
CAS No.: 210829-30-4
Purity:  99.14%
Synonyms: CP-4126; CO-101; gemcitabine 5'-elaidate
Target:  

Nucleoside Antimetabolite/Analog Autophagy Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Gemcitabine elaidate (CP-4126) is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity .
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5
Gemcitabine elaidate hydrochloride
Gemcitabine elaidate hydrochloride
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5 Cited Publications
Cat. No.: HY-13538A
CAS No.: 2918768-08-6
Purity:  99.89%
Synonyms: CP-4126 hydrochloride; CO-101 hydrochloride; gemcitabine 5'-elaidate hydrochloride
Target:  

Nucleoside Antimetabolite/Analog Autophagy Apoptosis

Research Areas:  

Cancer

Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate hydrochloride exhibits anti-tumor activity .
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4
MC3138
MC3138
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4 Cited Publications
Cat. No.: HY-160818
CAS No.: 1844889-12-8
Target:  

Sirtuin

Research Areas:  

Cancer

MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine (HY-17026) significantly inhibits tumor growth in mice .
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4
PF 477736
PF 477736
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4 Cited Publications
Cat. No.: HY-10032
CAS No.: 952021-60-2
Purity:  99.21%
Synonyms: PF 00477736
Target:  

Checkpoint Kinase (Chk) VEGFR Src c-Fms Aurora Kinase FGFR FLT3 RET CDK

Research Areas:  

Cancer

PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo .
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4
Ipafricept
Ipafricept
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4 Cited Publications
Cat. No.: HY-P99667
CAS No.: 1391727-24-4
Synonyms: OMP-54F28; FZD8-Fc

Target:  

Wnt

Research Areas:  

Cancer

Ipafricept (OMP-54F28; FZD8-Fc) is a first class recombinant fusion protein with the extracellular part of the human frizzled-8 receptor fused to a human IgG1 Fc fragment that binds Wnt ligands, which blocks Wnt signaling. Ipafricept reduces tumor growth and results in a decrease in both liver and lung metastases combined with Gemcitabine (HY-17026) in pancreatic cancer mouse models. Ipafricept shows solid tumor inhibition activity with well tolerance, such as desmoid tumor, germ cell cancer, ovarian cancer .
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2
LY2334737
LY2334737
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2 Cited Publications
Cat. No.: HY-13672
CAS No.: 892128-60-8
Purity:  98.55%
Target:  

Nucleoside Antimetabolite/Analog Enterovirus

Research Areas:  

Infection Cancer

LY2334737 is an nucleoside analog and is an orally active proagent of Gemcitabine. LY2334737 exhibits inhibitory activity against enterovirus A71 (EV-A71) infection. LY2334737 has antiviral and anticancer effects .
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1
Acelarin
Acelarin
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1 Cited Publications
Cat. No.: HY-100885
CAS No.: 840506-29-8
Purity:  99.80%
Synonyms: NUC-1031
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine.
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1
Gemcitabine monophosphate
Gemcitabine monophosphate
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1 Cited Publications
Cat. No.: HY-108932
CAS No.: 116371-67-6
Purity:  99.98%
Synonyms: gemcitabine 5′-phosphate
Target:  

Apoptosis

Research Areas:  

Cancer

Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026). Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles .
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1
SAR-020106
SAR-020106
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1 Cited Publications
Cat. No.: HY-100195
CAS No.: 1184843-57-9
Purity:  98.04%
Target:  

Checkpoint Kinase (Chk)

Research Areas:  

Cancer

SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC50 of 13.3 nM for human CHK1. SAR-020106 shows excellent selectivity over CHK2. SAR-020106 significantly enhances the cell killing of Gemcitabine and SN38 by 3- to 29-fold in several colon tumor lines and in a p53-dependent fashion. SAR-020106 can enhance antitumor activity with selected anticancer agents .
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1
Cyclopentenylcytosine
Cyclopentenylcytosine
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1 Cited Publications
Cat. No.: HY-106777
CAS No.: 90597-22-1
Purity:  99.76%
Synonyms: CPEC; NSC 375575
Target:  

DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis Necroptosis Influenza Virus HSV

Research Areas:  

Infection Cancer

Cyclopentenylcytosine (CPEC), a carbocyclic nucleoside analog of cytosine, is a potent inhibitor of CTP synthetase and causes depletion of CTP and dCTP pools. Cyclopentenylcytosine shows broad-spectrum (both DNA and RNA viruses) antiviral activity. Cyclopentenyl cytosine increases Gemcitabine (HY-17026) radiosensitisation in human pancreatic cancer cells. Cyclopentenylcytosine shows effective antiviral activity in the Ad5/NZW rabbit ocular replication model and shows anti-tumor activity in various tumor xenografts model. Cyclopentenylcytosine can be used for the study of infection and cancer .
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2′,2′-Difluorodeoxyuridine
2′,2′-Difluorodeoxyuridine
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Cat. No.: HY-138253
CAS No.: 114248-23-6
Purity:  99.87%
Synonyms: dFdU; 2',2'-Difluoro-2'-deoxyuridine
Target:  

Drug Metabolite Apoptosis

Research Areas:  

Cancer

2’,2’-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2’,2’-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro. 2’,2’-Difluorodeoxyuridine arrests cell cycle at the early S phase and induces apoptosis in cancer cells .
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Necitumumab
Necitumumab
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Cat. No.: HY-P9964
CAS No.: 906805-06-9
Synonyms: 11F8; IMC-11F8; LY3012211

Target:  

EGFR

Research Areas:  

Cancer

Necitumumab (11F8; IMC-11F8; LY3012211) is a human IgG monoclonal antibody directed against EGFR. Necitumumab binds to the EGF binding site of EGFR, blocks ligand binding, neutralizes ligand-induced EGFR phosphorylation and downstream signaling, induces EGFR internalization and degradation, and mediates antibody-dependent cellular cytotoxicity (ADCC) in EGFR-expressing cells. Necitumumab enhances antitumour activity in combination with Gemcitabine (HY-17026) and Cisplatin (HY-17394) in murine non-small-cell lung cancer xenograft models. Necitumumab can be used in research on cancers such as non-small cell lung cancer and colorectal cancer .
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Gemcitabine (Standard)
Gemcitabine (Standard)
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Cat. No.: HY-17026R
CAS No.: 95058-81-4
Synonyms: LY 188011 (Standard)
Target:  

Reference Standards Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy Apoptosis

Research Areas:  

Cancer

Gemcitabine (Standard) is the analytical standard of Gemcitabine. This product is intended for research and analytical applications. Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .
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Gemcitabine triphosphate trisodium
Gemcitabine triphosphate trisodium
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Cat. No.: HY-17026E
Synonyms: dFdCTP trisodium
Category:  

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

Drug Metabolite DNA/RNA Synthesis Apoptosis

Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate trisodium cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate trisodium shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate trisodium partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate trisodium disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate trisodium can be used for the research of pancreatic cancer and non-small cell lung cancer .
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AZM475271
AZM475271
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Cat. No.: HY-13561
CAS No.: 476159-98-5
Purity:  99.89%
Synonyms: M475271
Target:  

Src Apoptosis

Research Areas:  

Cancer

AZM475271 (M475271) is an orally active and selective Src kinase inhibitor. AZM475271 inhibits phosphorylation of c-Src kinase, Lck, c-yes (IC50s = 0.01, 0.03, 0.08 μM, respectively). AZM475271 induces apoptosis. AZM475271 reduces tumor cell proliferation and migration in vitro and in vivo, and reduces microvessel density (MVD). AZM475271 inhibits tumor growth and metastasis. AZM475271 sensitizes tumor cells to the cytotoxic effects of Gemcitabine (HY-17026) .
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Gemcitabine-13C,15N2 hydrochloride
Gemcitabine-13C,15N2 hydrochloride
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Cat. No.: HY-B0003S
CAS No.: 2757566-59-7
Synonyms: LY 188011-13C,15N2 hydrochloride
Gemcitabine- 13C, 15N2 (hydrochloride) is the 13C and 15N labeled Gemcitabine hydrochloride . Gemcitabine Hydrochloride (LY 188011 Hydrochloride) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis .
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Gemcitabine triphosphate
Gemcitabine triphosphate
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Cat. No.: HY-17026A
CAS No.: 110988-86-8
Synonyms: dFdCTP
Category:  

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:  

Drug Metabolite DNA/RNA Synthesis Apoptosis

Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer .
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Licoricidin
Licoricidin
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Cat. No.: HY-N3387
CAS No.: 30508-27-1
Category:  

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