9 Results for "

glucose binding site

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "glucose binding site" in MCE Product Catalog:

5
Isorhapontigenin
Isorhapontigenin
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5 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
Category:  

Plant Gnetaceae Extract Stilbenes Phenols Polyphenols Disease Research Fields Inflammation/Immunology Gnetum cleistostachyum C. Y. Cheng Extract

Target:  

Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes .
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Lunularin
Lunularin
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Cat. No.: HY-124529
CAS No.: 37116-80-6
Category:  

Conocephalum conicum (L.) Dumort. Extract Human Gut Microbiota Metabolites Plant Phenols Polyphenols Other Families Extract Endogenous metabolite

Target:  

11β-HSD Endogenous Metabolite

Lunularin is an inhibitor of 11β-hydroxysteroid dehydrogenase 1, with an IC50 of 45.44 μM and a Ki of 35.8 μM against human 11β-HSD1, and an IC50 of 17.39 μM and a Ki of 10.31 μM against rat 11β-HSD1. Lunularin upregulates the transcription levels of Sirt1 and Hmox1 genes in the liver. Lunularin reduces food intake and body weight gain, and decreases blood glucose levels in mice fed a high-fat diet. Lunularin inhibits LPS-induced TLR4-mediated NF-κB pathway activation and nitric oxide production. Lunularin inhibits the proliferation and colony formation of renal cancer and colon cancer cells, and exhibits cancer cell-specific cytotoxicity. Lunularin binds to the steroid-binding site of human 11β-HSD1 and the steroid/NADPH-binding region of rat 11β-HSD1, but does not inhibit 11β-HSD2 or mouse 11β-HSD1. Lunularin can be used in research related to diet-induced obesity, renal cancer, colorectal cancer, inflammatory diseases and metabolic syndrome .
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Aclimostat
Aclimostat
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Cat. No.: HY-114196
CAS No.: 2082752-83-6
Purity:  ≥98.0%
Synonyms: ZGN-1061
Target:  

MetAP

Research Areas:  

Metabolic Disease Cancer

Aclimostat (ZGN-1061) is a methionine aminopeptidase 2 (MetAP2) inhibitor. Aclimostat exhibits anti-obesity, anti-diabetic and ovarian cancer-related activities, and does not readily distribute to the central nervous system. Aclimostat acts on the active site of MetAP2 via irreversible covalent binding, and blocks enzyme activity through interactions with His231 and His339. Aclimostat regulates gene expression, reduces fat mass, plasma glucose, insulin levels, LDL-C, hs-CRP and leptin levels, while increasing adiponectin levels. Aclimostat can be used in research related to type 2 diabetes, overweight, obesity and ovarian cancer .
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4,6-O-Ethylidene-α-D-glucose
4,6-O-Ethylidene-α-D-glucose
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Cat. No.: HY-N7433
CAS No.: 13224-99-2
Synonyms: Ethylidene-glucose
Category:  

Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides

Target:  

GLUT Endogenous Metabolite

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport .
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Galantide
Galantide
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Cat. No.: HY-P0262
CAS No.: 138579-66-5
Target:  

Neuropeptide Y Receptor

Research Areas:  

Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology

Galantide, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide appears to bind to a single population of SP receptors (KD~40 nM) .
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4,6-O-Ethylidene-α-D-glucose (Standard)
4,6-O-Ethylidene-α-D-glucose (Standard)
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Cat. No.: HY-N7433R
CAS No.: 13224-99-2
Synonyms: Ethylidene-glucose (Standard)
Category:  

Endogenous metabolite Saccharides

Target:  

Reference Standards GLUT Endogenous Metabolite

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport .
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Isorhapontigenin (Standard)
Isorhapontigenin (Standard)
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Cat. No.: HY-N2593R
CAS No.: 32507-66-7
Category:  

Plant Gnetaceae Extract Stilbenes Phenols Polyphenols Gnetum cleistostachyum C. Y. Cheng Extract

Target:  

Reference Standards Carnitine Palmitoyltransferase (CPT) Reactive Oxygen Species (ROS) Autophagy Apoptosis NF-κB PI3K Akt MMP Keap1-Nrf2

Isorhapontigenin (Standard) is the analytical standard of Isorhapontigenin (HY-N2593). This product is intended for research and analytical applications. Isorhapontigenin is an orally active dietary polyphenol. Isorhapontigenin acts as a potent antioxidant that reduces the production of reactive oxygen species (ROS). Isorhapontigenin promotes the binding of JUN to the AP-1 site on the SESN2 promoter, induces SESN2 transcription, triggers MAPK8-dependent JUN activation, and upregulates the expression of PPAR-α, PGC-1α and CPT-1A to facilitate fatty acid oxidation. Isorhapontigenin induces autophagy, apoptosis and preadipocyte differentiation; it inhibits tumor growth, cell invasion, NF-κB transcriptional activity, the PI3K/Akt signaling pathway, STAT1 phosphorylation and MMP-2 expression. Isorhapontigenin alleviates oxidative stress, inflammatory cytokine release and triglyceride accumulation; it increases intracellular ATP levels and promotes Nrf2 nuclear translocation. Isorhapontigenin improves insulin sensitivity in adipose tissue and glucose tolerance, and reduces postprandial blood glucose, insulin and free fatty acid levels. Isorhapontigenin is applicable to research on bladder cancer, liver injury, chronic obstructive pulmonary disease, acute lung injury and type 2 diabetes.
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Zincov
Zincov
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Cat. No.: HY-183878
CAS No.: 71431-46-4
Target:  

Bacterial

Research Areas:  

Infection Metabolic Disease

Zincov is an orally active hydroxamic acid derivative and bacterial metalloproteinase inhibitor. Zincov blocks chloride ion binding by binding to the active site of thermolysin, thereby inhibiting the hydrolysis and blood coagulation reactions catalyzed by this enzyme. Meanwhile, Zincov attenuates cytotoxicity, prevents protein degradation and ZO-1 rearrangement without affecting the functions of other common proteases. Zincov exhibits blood glucose-regulating and antioxidant activities; it reduces blood glucose levels and increases liver dry weight in diabetic rats, but elevates blood glucose levels in normal rats. Zincov is widely used in studies related to cholera and diabetes .
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Concanavalin A-FITC
Concanavalin A-FITC
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Cat. No.: HY-D3030
Target:  

Fluorescent Dye

Research Areas:  

Others Inflammation/Immunology

Concanavalin A-FITC is a FITC (HY-66019)-labeled Concanavalin A (HY-P2149). Concanavalin A-FITC is a fluorescent probe and dye used to detect cell surface sugar-binding sites, oligosaccharide changes and track cell localization. Concanavalin A-FITC binds to α-D-glucose, α-D-mannose and mannose residues on cell surface glycoproteins, glycolipids and glycoconjugates, with fluorescence signals provided by FITC. Concanavalin A-FITC accumulates in perinuclear endoplasmic reticulum-related regions via endocytosis and localizes to mitochondria. The excitation/emission wavelength of Concanavalin A-FITC is Ex/Em = 488/>510 nm, and its emitted green fluorescence can be collected with a 530/30 nm filter during flow cytometry detection .
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