210 Results for "

hCA

" in MedChemExpress (MCE) Product Catalog:
Products (210)

210 Results for "hCA" in MCE Product Catalog:

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16
Acetazolamide
Acetazolamide
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16 Publications Verification
Cat. No.: HY-B0782
CAS No.: 59-66-5
Target:  

Carbonic Anhydrase Autophagy Bacterial

Research Areas:  

Cardiovascular Disease Cancer

Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities .
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16
Acetazolamide sodium
Acetazolamide sodium
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16 Publications Verification
Cat. No.: HY-B0782A
CAS No.: 1424-27-7
Target:  

Carbonic Anhydrase Autophagy Bacterial

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities .
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4
Zonisamide
Zonisamide
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4 Cited Publications
Cat. No.: HY-B0124
CAS No.: 68291-97-4
Synonyms: AD 810; CI 912
Target:  

Carbonic Anhydrase Apoptosis

Research Areas:  

Neurological Disease

Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .
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3
GSK256073
GSK256073
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3 Cited Publications
Cat. No.: HY-119222
CAS No.: 862892-90-8
Purity:  99.11%
Target:  

GPR109A

Research Areas:  

Metabolic Disease

GSK256073 is a potent, selective and orally active GPR109A agonist and a long-lasting and non-flushing HCA2 full agonist with a pEC50 of 7.5 (human HCA2). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis and has the potential for the study of type 2 diabetes mellitus (T2DM)and dyslipidemia . GPR109A: G-protein coupled receptor 109A; HCA2: hydroxy-carboxylic acid receptor 2
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2
Benzolamide
Benzolamide
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2 Cited Publications
Cat. No.: HY-118467
CAS No.: 3368-13-6
Purity:  99.07%
Synonyms: CL11366
Target:  

Carbonic Anhydrase

Research Areas:  

Neurological Disease Cancer

Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures .
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1
L-Homocysteic acid
L-Homocysteic acid
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1 Cited Publications
Cat. No.: HY-138903
CAS No.: 14857-77-3
Purity:  ≥98.0%
Synonyms: L-hCA
Target:  

iGluR

Research Areas:  

Neurological Disease

L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders .
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1
LUF6283
LUF6283
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1 Cited Publications
Cat. No.: HY-100976
CAS No.: 92933-48-7
Purity:  98.92%
Target:  

Hydroxycarboxylic Acid Receptor (HCAR)

Research Areas:  

Metabolic Disease

LUF6283 is a potent and orally active HCA(2) partial agonist, with a Ki of 0.55 µM. LUF6283 can achieve the beneficial lipid lowering effect of niacin without producing the unwanted cutaneous flushing side effect .
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1
L-161982
L-161982
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1 Cited Publications
Cat. No.: HY-108559
CAS No.: 147776-06-5
Purity:  99.30%
Target:  

Prostaglandin Receptor

Research Areas:  

Inflammation/Immunology

L-161982 is a selective EP4 receptor antagonist. L-161982 completely blocks PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 alleviates collagen-induced arthritis in mice .
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1
Fluorometholone acetate
Fluorometholone acetate
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1 Cited Publications
Cat. No.: HY-B1471
CAS No.: 3801-06-7
Target:  

Carbonic Anhydrase

Research Areas:  

Inflammation/Immunology

Fluorometholone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Fluorometholone acetate potently inhibits carbonic anhydrase (CA) with IC50s of 2.18 μM and 17.5 μM for hCA-I and hCA-II, respectively. Fluorometholone acetate has anti-inflammatory effect and has the potential for external ocular inflammation research .
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1
PhIP
PhIP
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1 Cited Publications
Cat. No.: HY-118716
CAS No.: 105650-23-5
Purity:  99.93%
Synonyms: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Category:  

Human Gut Microbiota Metabolites Endogenous metabolite

Target:  

Others

PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat . DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity .
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1
3,5-Dihydroxybenzoic acid
3,5-Dihydroxybenzoic acid
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1 Cited Publications
Cat. No.: HY-W015560
CAS No.: 99-10-5
Category:  

Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Phenols Polyphenols Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Tyrosinase Hydroxycarboxylic Acid Receptor (HCAR)

3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses. 3,5-Dihydroxybenzoic acid is the agonist for hydroxycarboxylic acid receptor 1 (HCA1, also known as GPR81) that inhibits lipolysis in adipocytes. 3,5-Dihydroxybenzoic acid is the competitive inhibitor for tyrosine phenol-lyase (TPL), exhibits an affinity of Ki=25.7 μM. 3,5-Dihydroxybenzoic acid is orally active .
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Carotegrast
Carotegrast
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Cat. No.: HY-14857
CAS No.: 401904-75-4
Purity:  99.22%
Synonyms: hCA2969
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

Carotegrast (HCA2969) is an orally active α4 integrin inhibitor with anti-inflammatory activity. Carotegrast can be used in the research of inflammation-related diseases, such as ulcerative colitis .
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Coumalic acid
Coumalic acid
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Cat. No.: HY-32004
CAS No.: 500-05-0
Category:  

Ketones, Aldehydes, Acids Other Diseases 500 - Internal Server Error | MedChemExpress

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