4

INH154

4 Cited Publications

Cat. No.: HY-117154

CAS No.: 1587705-63-2

Purity: 99.89%

Target:

NEKs

Research Areas:

Cancer

INH154 is a highly potent inhibitor for Nek2 and Hec1 binding (INH), with IC₅₀s of 200 nM and 120 nM for INH in Hela and MB468 cells.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

T-1101 tosylate

1 Cited Publications

Cat. No.: HY-120356A

CAS No.: 2250404-95-4

Purity: 99.05%

Synonyms: TAI-95 tosylate

Target:

NEKs Apoptosis

Research Areas:

Cancer

T-1101 tosylate (TAI-95 tosylate) is the tosylate salt form of T-1101 (HY-120356). T-1101 tosylate is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 tosylate blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI₅₀ of 15-70 nM. T-1101 tosylate induces apoptosis in Huh-7. T-1101 tosylate exhibits antitumor efficacy in mouse models .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

INH1

1 Cited Publications

Cat. No.: HY-16660

CAS No.: 313553-47-8

Synonyms: IBT13131

Target:

NEKs Apoptosis

Research Areas:

Cancer

INH1 specifically disrupts the Hec1/Nek2 interaction via direct Hec1 binding. INH1 shows promising cancer inhibition activity both in vitro and in vivo .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

TAI-1

Cat. No.: HY-B0790

CAS No.: 1334921-03-7

Target:

NEKs Apoptosis

Research Areas:

Cancer

TAI-1, an orally active anticancer agent, is a highly potent first-in-class Hec1 inhibitor, with a GI₅₀ of 13.48 nM in K562 cells .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Nek2/Hec1-IN-3

Cat. No.: HY-176463

CAS No.: 457940-87-3

Target:

NEKs

Research Areas:

Cancer

Nek2/Hec1-IN-3 (Compound 11-28) is a Hec1/Nek2 interaction inhibitor. Nek2/Hec1-IN-3 disrupts Nek2/Hec1 binding and can be used for research of neoplastic diseases .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

INH6

Cat. No.: HY-100541

CAS No.: 1001753-24-7

Purity: 99.53%

Target:

NEKs Apoptosis

Research Areas:

Cancer

INH6 is a potent Nek2/Hec1 inhibitor; inhibits the growth of HeLa cells with an IC₅₀ of 2.4 μM.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

HEC96719

Cat. No.: HY-153114

CAS No.: 2181834-03-5

Purity: 98.01%

Target:

FXR

Research Areas:

Inflammation/Immunology

HEC96719 is a selective and orally active tricyclic farnesoid X receptor (FXR) agonist with EC₅₀ values of 1.37 and 1.55 nM by time-resolved fluorescence energy transfer (TR-FRET) and luciferase reporter assays, respectively. HEC96719 significantly improves non-alcoholic steatohepatitis (NASH) and liver fibrosis with favorable tissue distribution in liver and intestine. HEC96719 can be used for the research of non-alcoholic steatohepatitis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

T-1101

Cat. No.: HY-120356

CAS No.: 1438638-83-5

Synonyms: TAI-95

Target:

Apoptosis NEKs

Research Areas:

Cancer

T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1). T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI₅₀ of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Nek2/Hec1-IN-2

Cat. No.: HY-153749

CAS No.: 544416-00-4

Purity: ≥98.0%

Target:

NEKs

Research Areas:

Cancer

Nek2/Hec1-IN-2 (Compound 14) is an inhibitor of Nek2/Hec1. Nek2/Hec1-IN-2 inhibits cancer cell proliferation with IC₅₀ >25 μM .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

SM1044

Cat. No.: HY-160962

CAS No.: 1331880-08-0

Target:

Caspase Apoptosis

Research Areas:

Cancer

SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC₅₀ < 3.6 μM . SM1044 inhbits tumor growth in RL95-2 xenograft mouse model .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

HEC72702

Cat. No.: HY-123767

CAS No.: 1793063-59-8

Target:

HBV

Research Areas:

Infection

HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC₅₀ values of 0.039 µM. HEC72702 dose-dependently reduced HBV DNA in both the plasma and livers .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

(R)-DPN

Cat. No.: HY-103453

CAS No.: 524047-78-7

Target:

Estrogen Receptor/ERR

Research Areas:

Endocrinology

(R)-DPN (compound 3) is a selective ERβ ligand with EC₅₀s of 2.9, 0.8 nM for ERα and ERβ, respectively. (R)-DPN shows a very high affinity and potency preference for ERβ over ERα. (R)-DPN shows cytoxicity for HEC-1 and U2OS cells with EC₅₀s of 286, 205 nM, respectively .

Compare

loading...