33 Results for "

hemodynamics

" in MedChemExpress (MCE) Product Catalog:
Products (33)

33 Results for "hemodynamics" in MCE Product Catalog:

14
Conivaptan hydrochloride
Conivaptan hydrochloride
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14 Publications Verification
Cat. No.: HY-18347A
CAS No.: 168626-94-6
Synonyms: YM 087
Target:  

Vasopressin Receptor Cytochrome P450

Conivaptan hydrochloride (YM 087) is an orally active dual vasopressin V1a/V2 receptor antagonist with Ki values of 0.48 nM and 3.04 nM for vasopressin V1a receptor and V2 receptor, respectively. Conivaptan hydrochloride competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan hydrochloride inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan hydrochloride induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan hydrochloride is used for research on hyponatremia and congestive heart failure .
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2
Sitaxsentan sodium
Sitaxsentan sodium
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2 Cited Publications
Cat. No.: HY-11103
CAS No.: 210421-74-2
Purity:  98.83%
Synonyms: IPI 1040 sodium; TBC11251 sodium
Target:  

Endothelin Receptor TGF-β Receptor

Research Areas:  

Cardiovascular Disease Metabolic Disease

Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan sodium can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .
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2
Sitaxsentan
Sitaxsentan
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2 Cited Publications
Cat. No.: HY-76520
CAS No.: 184036-34-8
Synonyms: IPI 1040; TBC-11251
Target:  

Endothelin Receptor TGF-β Receptor

Research Areas:  

Cardiovascular Disease Metabolic Disease

Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .
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1
6-Keto-PGE1
6-Keto-PGE1
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1 Cited Publications
Cat. No.: HY-114986
CAS No.: 67786-53-2
Purity:  ≥99.0%
Synonyms: 6-keto-Prostaglandin E1
Target:  

β-glucuronidase

Research Areas:  

Cardiovascular Disease

6-Keto-PGE1 (6-keto-Prostaglandin E1) is a biologically active derivative of PGE1. 6-Keto-PGE1 inhibits adenosine diphosphate-induced platelet aggregation. 6-Keto-PGE1 reduces cardiac afterload, decreases the accumulation of plasma myocardial depressant factor (MDF), lowers arterial blood pressure, dilates vascular beds, inhibits the vasoconstrictive response of vascular smooth muscle, and increases pulmonary compliance. 6-Keto-PGE1 directly stabilizes isolated cat liver lysosomes and significantly reduces the release of β-glucuronidase and cathepsin D. 6-Keto-PGE1 prolongs the survival time of traumatized rats and exerts protective effects through hemodynamic and cytoprotective actions. 6-Keto-PGE1 reduces central airway resistance. 6-Keto-PGE1 can be used in studies related to traumatic shock .
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3-Nitro-L-tyrosine
3-Nitro-L-tyrosine
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Cat. No.: HY-113248
CAS No.: 621-44-3
Purity:  ≥98.0%
Category:  

Monophenols Ketones, Aldehydes, Acids Disease markers Metabolic Disease Phenols Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder

Target:  

Endogenous Metabolite Adrenergic Receptor Reactive Oxygen Species (ROS)

3-Nitro-L-tyrosine serves as a biomarker of oxidative stress. 3-Nitro-L-tyrosine attenuates the pressor and vasoconstrictive effects of angiotensin II by inhibiting the α1-adrenergic receptor-mediated signaling pathway, and participates in hemodynamic regulation under pathological conditions such as inflammation and ischemia. 3-Nitro-L-tyrosine can be used in studies related to atherosclerosis, ischemia-reperfusion and sepsis .
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3-Nitro-L-tyrosine-d3
3-Nitro-L-tyrosine-d3
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Cat. No.: HY-113248S
CAS No.: 213386-10-8
Purity:  ≥99.0%
3-Nitro-L-tyrosine-d3 is the deuterium labeled 3-Nitro-L-tyrosine (HY-113248). 3-Nitro-L-tyrosine serves as a biomarker of oxidative stress. 3-Nitro-L-tyrosine attenuates the pressor and vasoconstrictive effects of angiotensin II by inhibiting the α1-adrenergic receptor-mediated signaling pathway, and participates in hemodynamic regulation under pathological conditions such as inflammation and ischemia. 3-Nitro-L-tyrosine can be used in studies related to atherosclerosis, ischemia-reperfusion and sepsis .
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ONO-AE 248
ONO-AE 248
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Cat. No.: HY-12184
CAS No.: 211230-67-0
Purity:  98.27%
Target:  

Prostaglandin Receptor Endogenous Metabolite

Research Areas:  

Cardiovascular Disease

ONO-AE 248 is a selective EP3 receptor agonist with cardioprotective activity. ONO-AE 248 reduces myocardial infarction size by selectively binding to the EP3α receptor in mice. The cardioprotective effect of ONO-AE 248 is independent of hemodynamic effects. The mechanism of ONO-AE 248 may involve activation of protein kinase C and opening of K(ATP) channels .
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GP3269
GP3269
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Cat. No.: HY-19259
CAS No.: 186393-42-0
Target:  

Adenosine Kinase

Research Areas:  

Neurological Disease

GP3269 is a selective and orally active human adenosine kinase (AK) inhibitor with an IC50 of 11 nM against human adenosine kinase. GP3269 increases adenosine levels at epileptic foci, activates A1 receptors on excitatory neurons, and exhibits anticonvulsant activity in rats. GP3269 does not induce hemodynamic effects including changes in blood pressure or heart rate in rats. GP3269 can be used for epilepsy-related research .
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Conivaptan
Conivaptan
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Cat. No.: HY-18347
CAS No.: 210101-16-9
Synonyms: YM 087 free base
Target:  

Vasopressin Receptor Cytochrome P450

Research Areas:  

Cardiovascular Disease Metabolic Disease

Conivaptan (YM 087 free base) is an orally active dual vasopressin V1a/V2 receptor antagonist with Ki values of 0.48 nM and 3.04 nM for vasopressin V1a receptor and V2 receptor, respectively. Conivaptan competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan is used for research on hyponatremia and congestive heart failure .
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Auriculin A
Auriculin A
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Cat. No.: HY-P3765
CAS No.: 91421-87-3
Target:  

Inhibitory Antibodies

Research Areas:  

Cardiovascular Disease

Auriculin A is a synthetic atrial natriuretic factor (ANF) with hemodynamic effect. Auriculin A antagonizes renal vasoconstriction in the dog, and influences on arterial baroreflex control of heart rate, systemic blood pressure, and perfusion pressure in the hind limb (perfused at constant flow) in rabbits .
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Taprostene
Taprostene
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Cat. No.: HY-114671
CAS No.: 108945-35-3
Synonyms: CG-4203
Target:  

Prostaglandin Receptor

Research Areas:  

Cardiovascular Disease

Taprostene (CG-4203) is a synthetic, chemically stable analogue of Prostacyclin (PGI2). Taprostene exhibits endothelium and myocardial protecting actions after acute myocardial ischemia and reperfusion in cats. Taprostene enhances cytoprotective actions, while minimizing unwanted hemodynamic effects .
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3-Nitro-L-tyrosine (Standard)
3-Nitro-L-tyrosine (Standard)
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Cat. No.: HY-113248R
CAS No.: 621-44-3
Category:  

Monophenols Ketones, Aldehydes, Acids Disease markers Phenols Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder

Target:  

Reference Standards Adrenergic Receptor Endogenous Metabolite Reactive Oxygen Species (ROS)

3-Nitro-L-tyrosine (Standard) is the analytical standard of 3-Nitro-L-tyrosine (HY-113248). This product is intended for research and analytical applications. 3-Nitro-L-tyrosine serves as a biomarker of oxidative stress. 3-Nitro-L-tyrosine attenuates the pressor and vasoconstrictive effects of angiotensin II by inhibiting the α1-adrenergic receptor-mediated signaling pathway, and participates in hemodynamic regulation under pathological conditions such as inflammation and ischemia. 3-Nitro-L-tyrosine can be used in studies related to atherosclerosis, ischemia-reperfusion and sepsis .
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Ciprokiren
Ciprokiren
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Cat. No.: HY-177326
CAS No.: 143631-62-3
Synonyms: Ro 44-9375
Target:  

Renin

Research Areas:  

Cardiovascular Disease

Ciprokiren (Ro 44-9375) is a Renin inhibitor with IC50s of 0.07 and 0.65 nM for hRenin in buffer and plasma, respectively. Ciprokiren be applied transdermally with similar hemodynamic effects without decrease of plasma renin activity or plasma immunoreactive angiotensin II. Ciprokiren has antihypertensive efficacy and can be used for hypertension research .
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Ibopamine hydrochloride
Ibopamine hydrochloride
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Cat. No.: HY-112072
CAS No.: 75011-65-3
Synonyms: SB 7505 hydrochloride; SKF 100168 hydrochloride
Target:  

Dopamine Receptor Adrenergic Receptor

Research Areas:  

Cardiovascular Disease

Ibopamine (SB 7505) hydrochloride is an orally active dopamine derivative. Ibopamine hydrochloride exerts agonistic effects on α, β adrenergic receptors and dopaminergic receptors. Ibopamine hydrochloride can be hydrolyzed to produce the active metabolite Epinine. Ibopamine hydrochloride possesses positive inotropic and vasodilatory effects, which can improve hemodynamics and renal function in heart failure models. Ibopamine hydrochloride has good safety profile and can be used in the research of diseases such as congestive heart failure .
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Sulfo-Cyanine5.5 carboxylic acid
Sulfo-Cyanine5.5 carboxylic acid
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Cat. No.: HY-D1366
CAS No.: 2183440-68-6
Target:  

Fluorescent Dye

Research Areas:  

Others

Sulfo-Cyanine5.5 carboxylic acid is a Fluorescent dye. Sulfo-Cyanine5.5 carboxylic acid emits red fluorescence, with a peak absorption wavelength of 673 nm. Sulfo-Cyanine5.5 carboxylic acid can be used to visualize aqueous sub-compartments and phase separation in synthetic multi-compartment microstructures. Sulfo-Cyanine5.5 carboxylic acid can serve as an intravenous contrast agent for in vivo cerebral perfusion imaging, mapping hemodynamics and perfusion regions .
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INF200
INF200
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Cat. No.: HY-155517
CAS No.: 3049730-43-7
Target:  

NOD-like Receptor (NLR) Pyroptosis

Research Areas:  

Inflammation/Immunology

INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD)-induced metaflammation，and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles，and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation .
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2-(Methylamino)ethanol
2-(Methylamino)ethanol
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Cat. No.: HY-Y1783
CAS No.: 109-83-1
Synonyms: N-Methylethanolamine
Category:  

Alkaloids Other Alkaloids 500 - Internal Server Error | MedChemExpress

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