47

Simeprevir

47 Publications Verification

Cat. No.: HY-10241

CAS No.: 923604-59-5

Purity: 98.79%

Synonyms: TMC435; TMC435350

Target:

HCV HCV Protease SARS-CoV DNA/RNA Synthesis

Research Areas:

Infection

Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M ^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

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46

Asunaprevir

46 Cited Publications

Cat. No.: HY-14434

CAS No.: 630420-16-5

Purity: 99.84%

Synonyms: BMS-650032

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Asunaprevir (BMS-650032) is a potent and orally bioavailable hepatitis C virus (HCV) NS3 protease inhibitor, with IC₅₀ of 0.2 nM-3.5 nM . Asunaprevir inhibits SARS-CoV-2 3CL ^pro activity .

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43

EIDD-1931

43 Cited Publications

Cat. No.: HY-125033

CAS No.: 3258-02-4

Purity: 99.96%

Synonyms: β-D-N4-hydroxycytidine; NHC

Target:

CHIKV SARS-CoV Enterovirus HCV Topoisomerase

Research Areas:

Infection

EIDD-1931 (Beta-d-N4-hydroxycytidine; NHC) is a novel nucleoside analog and behaves as a potent anti-virus agent. EIDD-1931 effectively inhibits the replication activity of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV) .

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31

U18666A

31 Cited Publications

Cat. No.: HY-107433

CAS No.: 3039-71-2

Purity: 99.77%

Target:

Flavivirus Dengue Virus HCV

Research Areas:

Infection Neurological Disease

U18666A, an intra-cellular cholesterol transport inhibitor, inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus .

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31

Ledipasvir D-tartrate

31 Cited Publications

Cat. No.: HY-15602B

CAS No.: 1502654-87-6

Purity: 98.76%

Synonyms: GS-5885 D-tartrate

Target:

HCV

Research Areas:

Infection

Ledipasvir D-tartrate is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

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31

Ledipasvir (acetone)

31 Cited Publications

Cat. No.: HY-15602A

CAS No.: 1441674-54-9

Purity: 99.92%

Synonyms: GS-5885 (acetone)

Target:

HCV

Research Areas:

Infection

Ledipasvir acetone (GS-5885 acetone) is the active ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC₅₀ values of 34 pM against GT1a and 4 pM against GT1b replicon.

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31

Ledipasvir

31 Cited Publications

Cat. No.: HY-15602

CAS No.: 1256388-51-8

Purity: 99.69%

Synonyms: GS-5885

Target:

HCV SARS-CoV

Research Areas:

Infection

Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC₅₀s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CL ^pro inhibitor with an IC₅₀ of 1.62 μM .

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30

Grazoprevir

30 Cited Publications

Cat. No.: HY-15298

CAS No.: 1350514-68-9

Purity: 99.99%

Synonyms: MK-5172

Target:

HCV Protease HCV SARS-CoV

Research Areas:

Infection

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir potassium salt

30 Cited Publications

Cat. No.: HY-15298A

CAS No.: 1206524-86-8

Purity: 99.63%

Synonyms: MK-5172 potassium salt

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir potassium salt inhibits SARS-CoV-2 3CL ^pro activity .

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30

Grazoprevir hydrate

30 Cited Publications

Cat. No.: HY-15298B

CAS No.: 1350462-55-3

Purity: 99.99%

Synonyms: MK-5172 hydrate

Target:

HCV HCV Protease SARS-CoV

Research Areas:

Infection

Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with K_is of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively . Grazoprevir hydrate inhibits SARS-CoV-2 3CL ^pro activity .

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22

Estradiol benzoate

22 Cited Publications

Cat. No.: HY-B1192

CAS No.: 50-50-0

Synonyms: β-Estradiol 3-benzoate; 17β-Estradiol 3-benzoate

Category:

Disease Research Fields Cancer

Target:

Estrogen Receptor/ERR HBV Bcl-2 Family

Estradiol benzoate (β-Estradiol 3-benzoate) is a HBx protein inhibitor and inhibits androgen and hepatitis B virus (HBV) transcription, replication. Estradiol benzoate shows antifertility effects, anti- Toxoplasma gondii activity and can improve memory behavior of Ovariectomy (Ovx) female mice .

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20

Lamivudine

20 Cited Publications

Cat. No.: HY-B0250

CAS No.: 134678-17-4

Synonyms: BCH-189

Target:

HIV Reverse Transcriptase HBV

Research Areas:

Infection Cancer

Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

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