149 Results for "

hepatotoxic

" in MedChemExpress (MCE) Product Catalog:
Products (149)

149 Results for "hepatotoxic" in MCE Product Catalog:

183
Docetaxel
Docetaxel
0 Images
183 Publications Verification
Cat. No.: HY-B0011
CAS No.: 114977-28-5
Synonyms: RP-56976
Category:  

Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Cancer

Target:  

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Docetaxel (RP-56976) is an orally active tubulin stabilizer with antitumor activity. Docetaxel is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel can be used in cancer-related research .
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183
Docetaxel Trihydrate
Docetaxel Trihydrate
0 Images
183 Publications Verification
Cat. No.: HY-B0011A
CAS No.: 148408-66-6
Synonyms: RP-56976 Trihydrate
Target:  

Microtubule/Tubulin Cytochrome P450 Apoptosis Drug Derivative

Research Areas:  

Cancer

Docetaxel Trihydrate (RP-56976 Trihydrate) is an orally active tubulin stabilizer with antitumor activity. Docetaxel Trihydrate is a P-glycoprotein substrate and is metabolized by CYP3A to inactive products. Docetaxel Trihydrate binds tubulin, promotes tubulin polymerization, and inhibits microtubule depolymerization. Docetaxel Trihydrate induces aberrant mitosis followed by necrotic-like cell death at low concentrations, and induces G2/M mitotic arrest and drives apoptosis at high concentrations. Docetaxel Trihydrate induces renal injury/renal alterations, sex-dependent granule toxicity/uptake, low cardiac delivery, and decreased hepatic SOD/increased catalase/hepatotoxicity. Docetaxel Trihydrate can be used in cancer-related research .
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10
Isoquercitrin
Isoquercitrin
0 Images
10 Cited Publications
Cat. No.: HY-N1445
CAS No.: 482-35-9
Synonyms: Isoquercetin; Quercetin 3-glucoside
Category:  

Flavonols Flavonoids Phenols Polyphenols Plants 500 - Internal Server Error | MedChemExpress

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