51

51 Publications Verification

Target:

Research Areas:

DNase I is an enzyme that degrades DNA. DNase I is mainly produced by digestive system organs, such as the pancreas and parotid gland. Three types of DNase I are known in mammals: pancreatic type, parotid type, and pancreatico-parotid type. DNase I plays a key role in the cleavage of extracellular DNA, and is critical for limiting inflammatory responses and maintaining homeostasis. DNase I is responsible for digesting extracellular nucleoproteins, which may be essential for preventing autoimmune reactions. Decreased DNase I activity may be associated with the occurrence and development of systemic lupus erythematosus (SLE). DNase I (filtered) is filtered through a 0.22 μM membrane and is not tested for pyrogenicity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

21

Hyaluronidase, Bovine testes

21 Cited Publications

Cat. No.: HY-107910

CAS No.: 37326-33-3

Synonyms: Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes

Target:

NF-κB

Research Areas:

Inflammation/Immunology Cancer

Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

21

Hyaluronidase, Ovine testes

21 Cited Publications

Cat. No.: HY-108903A

CAS No.: 37326-33-3

Purity: 95.00%

Target:

Glycosidase Biochemical Assay Reagents

Research Areas:

Endocrinology

Hyaluronidase, Ovine testes is an endoglycosidase. Hyaluronidase, Ovine testes specifically degrades Hyaluronic acid (HY-B0633A) and Chondroitin sulfate (HY-B2162) by hydrolyzing β-glycosidic bonds in acidic mucopolysaccharides. Hyaluronidase, Ovine testes disperses follicular cells during fertilization by breaking down the hyaluronic acid-rich cumulus. Hyaluronidase, Ovine testes can be used in the study of fertility-related diseases .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

13

Sodium citrate dihydrate, meets USP testing specifications

13 Cited Publications

Cat. No.: HY-B1610E

CAS No.: 6132-04-3

Synonyms: Trisodium citrate dihydrate, meets USP testing specifications

Sodium citrate (Trisodium citrate) dihydrate, meets USP testing specifications is an orally active natural product that can be found in citrus fruits. Sodium citrate dihydrate can inhibit the proliferation of tumor cells and induce apoptosis. Sodium citrate dihydrate has antibacterial, anti-tumor and antioxidant activities. Sodium citrate dihydrate can be prepared as a cosolvent or buffer .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

11

Z-Gly-Gly-Arg-AMC

11 Cited Publications

Cat. No.: HY-P0019

CAS No.: 66216-78-2

Target:

Fluorescent Dye Thrombin

Research Areas:

Cardiovascular Disease

Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

11

Z-Gly-Gly-Arg-AMC acetate

11 Cited Publications

Cat. No.: HY-P0019A

CAS No.: 2070009-61-7

Target:

Fluorescent Dye Thrombin

Research Areas:

Others

Z-Gly-Gly-Arg-AMC acetate is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

11

Pirtobrutinib

11 Cited Publications

Cat. No.: HY-131328

CAS No.: 2101700-15-4

Purity: 99.88%

Synonyms: LOXO-305

Target:

Btk

Research Areas:

Cancer

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

8

Crenigacestat

8 Cited Publications

Cat. No.: HY-12449

CAS No.: 1421438-81-4

Purity: 99.01%

Synonyms: LY3039478

Target:

Notch γ-secretase

Research Areas:

Cancer

Crenigacestat (LY3039478) is an orally active Notch and γ-secretase inhibitor, with an IC₅₀ of 1 nM in most of the tumor cell lines tested .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

7

Cyclopiazonic acid

7 Cited Publications

Cat. No.: HY-N6771

CAS No.: 18172-33-3

Category:

Alkaloids Microorganisms Pyrrole Alkaloids Other Diseases Disease Research Fields Indole Alkaloids

Target:

Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV

Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC₅₀ value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B ^[1][4][5].

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

Tyrphostin A9

6 Cited Publications

Cat. No.: HY-15511

CAS No.: 10537-47-0

Purity: 99.87%

Synonyms: Tyrphostin 9; Malonoben

Target:

Environmental Pollutants VEGFR PDGFR Influenza Virus

Research Areas:

Infection Cancer

Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

L-685458

6 Cited Publications

Cat. No.: HY-19369

CAS No.: 292632-98-5

Synonyms: L-685,458

Target:

γ-secretase Apoptosis

Research Areas:

Neurological Disease Cancer

L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC₅₀ of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC₅₀s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

5

Cuprizone

5 Cited Publications

Cat. No.: HY-W115718

CAS No.: 370-81-0

Target:

Dopamine β-hydroxylase

Research Areas:

Neurological Disease

Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

Congo Red

4 Cited Publications

Cat. No.: HY-D0236

CAS No.: 573-58-0

Congo Red is an azo dye. Congo Red (CR) binding been used as a diagnostic test for the presence of amyloid in tissue sections.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

SDMA

4 Cited Publications

Cat. No.: HY-101410

CAS No.: 30344-00-4

Purity: ≥98.0%

Synonyms: Symmetric dimethylarginine; NG,NG'-Dimethyl-L-arginine

Category:

Human Gut Microbiota Metabolites Other disease Ketones, Aldehydes, Acids Disease markers Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite NO Synthase NF-κB

SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. SDMA, a novel kidney biomarker, permits earlier diagnosis of kidney disease than traditional creatinine testing.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

Win 18446

4 Cited Publications

Cat. No.: HY-W011094

CAS No.: 1477-57-2

Target:

Aldehyde Dehydrogenase (ALDH)

Research Areas:

Endocrinology

Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC₅₀ of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

Mavoglurant

4 Cited Publications

Cat. No.: HY-15257

CAS No.: 543906-09-8

Purity: 99.88%

Synonyms: AFQ056

Target:

mGluR

Research Areas:

Neurological Disease

Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC₅₀ of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be used for the research of Fragile X syndrome (FXS), and L-dopa induced dyskinesias in Parkinson's disease . Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

Diphenyl Blue

4 Cited Publications

Cat. No.: HY-D0970

CAS No.: 72-57-1

Synonyms: Direct Blue 14; Trypan Blue

Diphenyl Blue (Trypan Blue) is a cell active dye, the most commonly used dye for the identification of dead cells, of en used to test cell membrane integrity and cell viability. Diphenyl Blue staining is one of the methods for tissue and cell culture. When cells are deactivated or have incomplete cell membranes, Diphenyl Blue can stain them Blue. Normal living cells with intact cell membranes reject Diphenyl blue and do not stain them blue. However, macrophages are capable of phagocytosis of Diphenyl Blue, so it can be used as a living stain for macrophages .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

3

DODAP

3 Cited Publications

Cat. No.: HY-130751

CAS No.: 127512-29-2

Purity: ≥98.0%

Target:

Liposome

Research Areas:

Inflammation/Immunology

DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .

Compare

loading...