30 Results for "

heterogeneity

" in MedChemExpress (MCE) Product Catalog:
Products (30)

30 Results for "heterogeneity" in MCE Product Catalog:

2
Eleclazine hydrochloride
Eleclazine hydrochloride
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2 Cited Publications
Cat. No.: HY-16738A
CAS No.: 1448754-43-5
Synonyms: GS 6615 hydrochloride
Target:  

Sodium Channel Potassium Channel

Research Areas:  

Cardiovascular Disease

Eleclazine (GS 6615) hydrochloride is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 value of <1 μM and approximately 14.2 μM, respectively. Eleclazine hydrochloride shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine hydrochloride can be used to research cardiac arrhythmias .
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Eleclazine
Eleclazine
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2 Cited Publications
Cat. No.: HY-16738
CAS No.: 1443211-72-0
Synonyms: GS-6615
Target:  

Sodium Channel Potassium Channel

Research Areas:  

Cardiovascular Disease

Eleclazine (GS 6615) is a selective cardiac late sodium current inhibitor and a weak inhibitor of potassium current with IC50 of <1 μM and approximately 14.2 μM, respectively. Eleclazine shows concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in porcine model. Eleclazine can be used to research cardiac arrhythmias .
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8-Bromoguanosine
8-Bromoguanosine
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Cat. No.: HY-W019033
CAS No.: 4016-63-1
Target:  

Nucleoside Antimetabolite/Analog

Research Areas:  

Others

8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .
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Simtuzumab
Simtuzumab
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Cat. No.: HY-P99047
CAS No.: 1318075-13-6
Synonyms: AB 0024; GS 6624

Target:  

Monoamine Oxidase

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab non-competitively blocks collagen cross-linking, reduces LOXL2 protein expression and attenuates extracellular matrix changes. Simtuzumab reduces myocardial fibrosis and prevents cardiac dysfunction. Simtuzumab lowers Myh7 and Nppa gene expression, reduces contraction heterogeneity, and cuts COL1A1 deposition. Simtuzumab can be used for the research of LMNA mutation-induced dilated cardiomyopathy, idiopathic pulmonary fibrosis, and primary sclerosing cholangitis .
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LM-189
LM-189
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Cat. No.: HY-171978
Target:  

Adrenergic Receptor

Research Areas:  

Cardiovascular Disease

LM-189 is a β2-adrenergic receptor (β2AR) ligand and G protein-biased modulator with a human β2AR Ki of 0.063 nM.LM-189 promotes β2AR coupling to Gαs and Gαi heterotrimers, stabilizes distinct β2AR conformations including a TM6 outward state, and increases β2AR ICL2 dynamics.LM-189 restricts β2AR ligand-binding pocket conformational heterogeneity, stabilizes polar ligand-receptor interaction networks, and exhibits bias toward Gαi signaling over Gαs signaling.LM-189 enabled cryo-EM structural characterization of the β2AR-Gi complex.LM-189 can be used for the research of congestive heart failure .
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Recainam
Recainam
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Cat. No.: HY-105454
CAS No.: 74738-24-2
Synonyms: Wy-42362
Target:  

Sodium Channel

Research Areas:  

Cardiovascular Disease

Recainam (Wy-42362) is a potent orally active antiarrhythmic agent and a sodium channel inhibitor. Recainam elevates ventricular fibrillation threshold, suppresses induced cardiac dysrhythmias, and may accentuate cardiac tissue refractoriness heterogeneity. Recainam can be used for the research of arrhythmias .
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LyP-2
LyP-2
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Cat. No.: HY-P4088
CAS No.: 850859-24-4
Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

LyP-2 is a peptide that homes to tumor lymphatics. LyP2 homes to lymphatics of C8161 melanomas and cervical carcinomas and K14-HPV16 skin, but not to MDA-MB435 tumors, showing heterogeneity in the molecular markers of tumor cells and lymphatics .
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FR900098 sodium
FR900098 sodium
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Cat. No.: HY-122817
CAS No.: 73226-73-0
Target:  

Antibiotic Parasite

Research Areas:  

Infection

FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice .
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NK224
NK224
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Cat. No.: HY-P10978
CAS No.: 3137461-57-2
Target:  

PD-1/PD-L1

Research Areas:  

Cancer

NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide (68Ga and 18F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC50 value of 2.45 nM. NK224 visualizes tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC) .
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Chol-N3
Chol-N3
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Cat. No.: HY-152901
CAS No.: 2106868-12-4
Target:  

Fluorescent Dye

Research Areas:  

Others

Chol-N3 is a bioorthogonal-based chol probe. Chol-N3 can combine with super-resolution fluorescence microscopy (SRM), providing direct visualization of nanoscale lipid heterogeneity in the cell surface of resting living cells . Chol-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Recainam hydrochloride
Recainam hydrochloride
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Cat. No.: HY-105454A
CAS No.: 74752-07-1
Synonyms: Wy-42362 hydrochloride
Target:  

Sodium Channel

Research Areas:  

Cardiovascular Disease

Recainam (Wy-42362) hydrochloride is a potent orally active antiarrhythmic agent and a sodium channel inhibitor. Recainam hydrochloride elevates ventricular fibrillation threshold, suppresses induced cardiac dysrhythmias, and may accentuate cardiac tissue refractoriness heterogeneity. Recainam hydrochloride can be used for the research of arrhythmias .
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FR900098
FR900098
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Cat. No.: HY-W795264
CAS No.: 66508-32-5
Target:  

Parasite

Research Areas:  

Infection

FR900098 is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 has no effect on bone marrow red blood cells in NMRI mice .
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8-Bromoguanosine-13C2,15N
8-Bromoguanosine-13C2,15N
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Cat. No.: HY-W747965
8-Bromoguanosine- 13C2, 15N is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .
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8-Bromoguanosine-13C,15N2
8-Bromoguanosine-13C,15N2
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Cat. No.: HY-W767371
8-Bromoguanosine- 13C, 15N2 is the 13C- and 15N-labeled 8-Bromoguanosine (HY-W019033). 8-Bromoguanosine is a purine nucleoside, a brominated derivative of guanosine. 8-Bromoguanosine can reduce the conformational heterogeneity of RNA to enhance its function .
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ABri
ABri
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Cat. No.: HY-P11314
CAS No.: 241145-90-4
Target:  

Amyloid-β

Research Areas:  

Cardiovascular Disease Neurological Disease

ABri, 34 amino acids long, is an Amyloid subunit with certain degree of N- and C-terminal heterogeneity and no sequence identity to any known amyloid protein. ABri is devoid of glycine, methionine, proline, aspartic acid, tryptophane, tyrosine and glutamine, featuring pyroglutamate at its N-terminus. ABri can be used for cerebral hemorrhages, ischemic infarction and Alzheimer disease research .
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23-Hydroxylongispinogenin
23-Hydroxylongispinogenin
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Cat. No.: HY-N2274
CAS No.: 42483-24-9
Synonyms: 12-Oleanene-3β,16β,23,28-tetrol; 3β,16β-12-Oleanene-3, 16,23,28-tetrol
Category:  

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