415

2-Deoxy-D-glucose

415 Publications Verification

Cat. No.: HY-13966

CAS No.: 154-17-6

Purity: 99.93%

Synonyms: 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose

Category:

Microorganisms Endogenous metabolite Disease Research Fields Saccharides Cancer Monosaccharides

Target:

Hexokinase HSV Apoptosis

2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

38

3-Bromopyruvic acid

38 Cited Publications

Cat. No.: HY-19992

CAS No.: 1113-59-3

Synonyms: Bromopyruvic acid; 3-BrPA; hexokinase II Inhibitor II, 3-BP

Target:

Hexokinase Apoptosis Autophagy

Research Areas:

Cancer

3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

22

Lonidamine

22 Cited Publications

Cat. No.: HY-B0486

CAS No.: 50264-69-2

Synonyms: AF-1890; Diclondazolic Acid; DICA

Target:

Hexokinase Mitochondrial Metabolism Apoptosis Parasite

Research Areas:

Metabolic Disease Inflammation/Immunology Cancer

Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (K_i: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

Benitrobenrazide

2 Cited Publications

Cat. No.: HY-134929

CAS No.: 2454676-05-0

Purity: 99.91%

Synonyms: BNBZ; hexokinase 2 inhibitor 1

Target:

Hexokinase Apoptosis

Research Areas:

Cancer

Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC₅₀ of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

PROTAC HK2 Degrader-1

2 Cited Publications

Cat. No.: HY-155008

CAS No.: 3033812-84-6

Purity: 98.98%

Target:

PROTACs Hexokinase

Research Areas:

Cancer

PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

2

2-Deoxy-D-glucose 6-phosphate disodium

2 Cited Publications

Cat. No.: HY-139409A

CAS No.: 33068-19-8

Purity: ≥98.0%

Target:

Hexokinase Glucose-6-Phosphate Isomerase (GPI)

Research Areas:

Cancer

2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

2-Deoxy-D-glucose-d1

1 Cited Publications

Cat. No.: HY-13966S

CAS No.: 188004-07-1

Purity: ≥98.0%

Synonyms: 2-DG-d₁; 2-Deoxy-D-arabino-hexose-d₁; D-Arabino-2-deoxyhexose-d₁

2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

HK2 Protein, Human (sf9, His)

1 Cited Publications

Cat. No.: HY-P703943

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: HK2; HKII; hexokinase 2; hexokinase-2, Muscle; hexokinase Type II; Phosphotransferase; hexokinase-2; HK II; Muscle Form hexokinase; HXK2; hexokinase-B

Species:

Human

Source:

Sf9 insect cells

Compare

loading...