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19 Results for "

hexokinase 2

" in MedChemExpress (MCE) Product Catalog:

Products (19)

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Benitrobenrazide

2 Cited Publications

Cat. No.: HY-134929

CAS No.: 2454676-05-0

Purity: 99.91%

Synonyms: BNBZ; hexokinase 2 inhibitor 1

Target:

Hexokinase Apoptosis

Research Areas:

Cancer

Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC₅₀ of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect .

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PROTAC HK2 Degrader-1

2 Cited Publications

Cat. No.: HY-155008

CAS No.: 3033812-84-6

Purity: 98.98%

Target:

PROTACs Hexokinase

Research Areas:

Cancer

PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .

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2-Deoxy-D-glucose 6-phosphate disodium

2 Cited Publications

Cat. No.: HY-139409A

CAS No.: 33068-19-8

Purity: ≥98.0%

Target:

Hexokinase Glucose-6-Phosphate Isomerase (GPI)

Research Areas:

Cancer

2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research .

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HK2 Protein, Human (sf9, His)

1 Cited Publications

Cat. No.: HY-P703943

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: HK2; HKII; hexokinase 2; hexokinase-2, Muscle; hexokinase Type II; Phosphotransferase; hexokinase-2; HK II; Muscle Form hexokinase; HXK2; hexokinase-B

Species:

Human

Source:

Sf9 insect cells

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HK-2-IN-1

Cat. No.: HY-175035

CAS No.: 3114833-48-3

Target:

Hexokinase

Research Areas:

Inflammation/Immunology Cancer

HK-2-IN-1 is a Hexokinase 2 (HK-2) inhibitor. HK-2-IN-1 exhibits a non-activating effect on human recombinant HK-2 enzyme. HK-2-IN-1 has anti-tumor activity, affecting immune cells in the tumor microenvironment. HK-2-IN-1 has immunomodulatory effects and is potentially useful in the study of cancers such as colon cancer, liver cancer, and breast cancer .

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